scholarly journals Genome-wide analysis of promoter architecture in Drosophila melanogaster

2010 ◽  
Vol 21 (2) ◽  
pp. 182-192 ◽  
Author(s):  
R. A. Hoskins ◽  
J. M. Landolin ◽  
J. B. Brown ◽  
J. E. Sandler ◽  
H. Takahashi ◽  
...  
2006 ◽  
Vol 38 (6) ◽  
pp. 700-705 ◽  
Author(s):  
Yuri B Schwartz ◽  
Tatyana G Kahn ◽  
David A Nix ◽  
Xiao-Yong Li ◽  
Richard Bourgon ◽  
...  

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Adam J. Dobson ◽  
John M. Chaston ◽  
Peter D. Newell ◽  
Leanne Donahue ◽  
Sara L. Hermann ◽  
...  

2001 ◽  
Vol 109 (2) ◽  
pp. 371-375 ◽  
Author(s):  
Frédéric Crémazy ◽  
Philippe Berta ◽  
Franck Girard

2007 ◽  
Vol 39 (9) ◽  
pp. 1174-1174 ◽  
Author(s):  
Piero Carninci ◽  
Albin Sandelin ◽  
Boris Lenhard ◽  
Shintaro Katayama ◽  
Kazuro Shimokawa ◽  
...  

Genetics ◽  
2021 ◽  
Author(s):  
Jacinta Davis ◽  
Claire Da Silva Santos ◽  
Narda Caudillo Zavala ◽  
Nicholas Gans ◽  
Daniel Patracuolla ◽  
...  

Abstract Parkinson’s Disease (PD) is primarily characterized by the loss of dopaminergic (DA) neurons in the brain. However, little is known about why DA neurons are selectively vulnerable to PD. To identify genes that are associated with DA neuron loss, we screened through 201 wild-caught populations of Drosophila melanogaster as part of the Drosophila Genetic Reference Panel (DGRP). Here we identify the top associated genes containing SNPs that render DA neurons vulnerable. These genes were further analyzed by using mutant analysis and tissue-specific knockdown for functional validation. We found that this loss of DA neurons caused progressive locomotor dysfunction in mutants and gene knockdown analysis. The identification of genes associated with the progressive loss of DA neurons should help to uncover factors that render these neurons vulnerable in PD, and possibly develop strategies to make these neurons more resilient.


2006 ◽  
Vol 15 (4) ◽  
pp. 455-464 ◽  
Author(s):  
W. Sun ◽  
V. M. Margam ◽  
L. Sun ◽  
G. Buczkowski ◽  
G. W. Bennett ◽  
...  

PLoS Genetics ◽  
2016 ◽  
Vol 12 (1) ◽  
pp. e1005616 ◽  
Author(s):  
Sibylle Chantal Vonesch ◽  
David Lamparter ◽  
Trudy F. C. Mackay ◽  
Sven Bergmann ◽  
Ernst Hafen

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