scholarly journals Crystallization and preliminary crystallographic analysis of the fusion core of the spike protein of the murine coronavirus mouse hepatitis virus (MHV)

2004 ◽  
Vol 60 (11) ◽  
pp. 2013-2015 ◽  
Author(s):  
Yanhui Xu ◽  
Zhihong Bai ◽  
Lan Qin ◽  
Xu Li ◽  
George Gao ◽  
...  
Keyword(s):  
Hepatitis Virus ◽  
Mouse Hepatitis Virus ◽  
Crystallographic Analysis ◽  
Spike Protein ◽  
Murine Coronavirus

A Spike Protein-Dependent Cellular Factor Other Than the Viral Receptor Is Required for Mouse Hepatitis Virus Entry

Virology ◽  
1993 ◽  
Vol 196 (1) ◽  
pp. 45-56 ◽  
Author(s):  
Kyoko Yokomori ◽  
Miyuki Asanaka ◽  
Stephen A. Stohlman ◽  
Michael M.C. Lai
Keyword(s):  
Hepatitis Virus ◽  
Virus Entry ◽  
Mouse Hepatitis Virus ◽  
Spike Protein ◽  
Viral Receptor ◽  
Cellular Factor

scholarly journals Attachment of Mouse Hepatitis Virus to O-Acetylated Sialic Acid Is Mediated by Hemagglutinin-Esterase and Not by the Spike Protein

2010 ◽  
Vol 84 (17) ◽  
pp. 8970-8974 ◽  
Author(s):  
Martijn A. Langereis ◽  
Arno L. W. van Vliet ◽  
Willemijn Boot ◽  
Raoul J. de Groot
Keyword(s):  
Sialic Acid ◽  
Hepatitis Virus ◽  
Mouse Hepatitis Virus ◽  
Protein S ◽  
Sialic Acids ◽  
The Other ◽  
Spike Protein ◽  
Apparent Contrast ◽  
Group A ◽  
New Hosts

ABSTRACT The members of Betacoronavirus phylocluster A possess two types of surface projections, one comprised of the spike protein (S) and the other of hemagglutinin-esterase (HE). Purportedly, these viruses bind to O-acetylated sialic acids (O-Ac-Sias) primarily through S, with HE serving merely as receptor-destroying enzyme. Here, we show that, in apparent contrast to human and ungulate host range variants of Betacoronavirus-1, murine coronaviruses actually bind to O-Ac-Sias via HE exclusively. Apparently, expansion of group A betacoronaviruses into new hosts and niches was accompanied by changes in HE ligand and substrate preference and in the roles of HE and S in Sia receptor usage.

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