An efficient seeded tree alignment algorithm for finding the similarity score of two RNA secondary structures

Author(s):  
Mohammad Shamsur Rahman ◽  
Abul Kashem Mia
2017 ◽  
Author(s):  
Michela Quadrini ◽  
Luca Tesei ◽  
Emanuela Merelli ◽  

The methods proposed in the literature for RNA comparison focus mainly on pseudoknot free structures. The comparison of pseudoknotted structures is still a challenge. In this work, we propose a new algebraic representation of RNA secondary structures based on relations among hairpins in terms of nesting, crossing, and concatenation. Such algebraic representation is obtained from a defined multiple context-free grammar, which maps any kind of RNA secondary structures into extended trees, i.e., ordered trees where internal nodes are labeled with algebraic operators and leaves are labeled with loops. These extended trees permit the definition of the RNA secondary structure comparison as a tree alignment problem.


2017 ◽  
Author(s):  
Michela Quadrini ◽  
Luca Tesei ◽  
Emanuela Merelli ◽  

The methods proposed in the literature for RNA comparison focus mainly on pseudoknot free structures. The comparison of pseudoknotted structures is still a challenge. In this work, we propose a new algebraic representation of RNA secondary structures based on relations among hairpins in terms of nesting, crossing, and concatenation. Such algebraic representation is obtained from a defined multiple context-free grammar, which maps any kind of RNA secondary structures into extended trees, i.e., ordered trees where internal nodes are labeled with algebraic operators and leaves are labeled with loops. These extended trees permit the definition of the RNA secondary structure comparison as a tree alignment problem.


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2016 ◽  
Vol 22 (11) ◽  
pp. 1739-1749 ◽  
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Ragnhild Weel-Sneve ◽  
James A. Booth ◽  
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Vol 93 (11) ◽  
pp. 2019-2023 ◽  
Author(s):  
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Vol 13 (5) ◽  
pp. 450-460 ◽  
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Lin Gao ◽  
Yu Wang ◽  
David K.Y. Chiu ◽  
Bingbo Wang ◽  
...  

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