Detectability of perfusion defect in gated dynamic cardiac SPECT images

Author(s):  
Xiaofeng Niu ◽  
Yongyi Yang ◽  
Miles N. Wernick
2010 ◽  
Vol 37 (9) ◽  
pp. 5102-5112 ◽  
Author(s):  
Xiaofeng Niu ◽  
Yongyi Yang ◽  
Michael A. King ◽  
Miles N. Wernick

Author(s):  
Anna Teresińska ◽  
Olgierd Woźniak ◽  
Aleksander Maciąg ◽  
Jacek Wnuk ◽  
Jarosław Jezierski ◽  
...  

Abstract Objective Impaired cardiac adrenergic activity has been demonstrated in heart failure (HF) and in diabetes mellitus (DM). [123I]I-metaiodobenzylguanidine (MIBG) enables assessment of the cardiac adrenergic nervous system. Tomographic imaging of the heart is expected to be superior to planar imaging. This study aimed to determine the quality and utility of MIBG SPECT in the assessment of cardiac innervation in postinfarction HF patients without DM, qualified for implantable cardioverter defibrillator (ICD) in primary prevention of sudden cardiac death. Methods Consecutive patients receiving an ICD on the basis of contemporary guidelines were prospectively included. Planar MIBG studies were followed by SPECT. The essential analysis was based on visual assessment of the quality of SPECT images (“high”, “low” or “unacceptable”). The variables used in the further analysis were late summed defect score for SPECT images and heart-to-mediastinum rate for planar images. MIBG images were assessed independently by two experienced readers. Results Fifty postinfarction nondiabetic HF subjects were enrolled. In 13 patients (26%), the assessment of SPECT studies was impossible. In addition, in 13 of 37 patients who underwent semiquantitative SPECT evaluation, the assessment was equivocal. Altogether, in 26/50 patients (52%, 95% confidence interval 38–65%), the quality of SPECT images was unacceptable or low and was limited by low MIBG cardiac uptake and by comparatively high, interfering MIBG uptake in the neighboring structures (primarily, in the lungs). Conclusions The utility of MIBG SPECT imaging, at least with conventional imaging protocols, in the qualification of postinfarction HF patients for ICD, is limited. In approximately half of the postinfarction HF patients, SPECT assessment of cardiac innervation can be impossible or equivocal, even without additional damage from diabetic cardiac neuropathy. The criteria predisposing the patient to good-quality MIBG SPECT are: high values of LVEF from the range characterizing the patients qualified to ICD (i.e., close to 35%) and left lung uptake intensity in planar images comparable to or lower than heart uptake.


Author(s):  
Duo Zhang ◽  
P. Hendrik Pretorius ◽  
Kaixian Lin ◽  
Weibing Miao ◽  
Jingsong Li ◽  
...  

2005 ◽  
Vol 26 (9) ◽  
pp. 801-807 ◽  
Author(s):  
Kazuyoshi Suga ◽  
Kawakami Yasuhiko ◽  
Hideyuki Iwanaga ◽  
Norio Hayashi ◽  
Tomio Yamashita ◽  
...  

2018 ◽  
Vol 26 (5) ◽  
pp. 1526-1538 ◽  
Author(s):  
Chao Song ◽  
Yongyi Yang ◽  
Albert Juan Ramon ◽  
Miles N. Wernick ◽  
P. Hendrik Pretorius ◽  
...  

2008 ◽  
Vol 15 (4) ◽  
pp. e23-e23
Author(s):  
R VENKATARAMAN ◽  
J HEO ◽  
A ISKANDRIAN

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Maria Lyra ◽  
Agapi Ploussi ◽  
Maritina Rouchota ◽  
Stella Synefia

Nuclear cardiac imaging is a noninvasive, sensitive method providing information on cardiac structure and physiology. Single photon emission tomography (SPECT) evaluates myocardial perfusion, viability, and function and is widely used in clinical routine. The quality of the tomographic image is a key for accurate diagnosis. Image filtering, a mathematical processing, compensates for loss of detail in an image while reducing image noise, and it can improve the image resolution and limit the degradation of the image. SPECT images are then reconstructed, either by filter back projection (FBP) analytical technique or iteratively, by algebraic methods. The aim of this study is to review filters in cardiac 2D, 3D, and 4D SPECT applications and how these affect the image quality mirroring the diagnostic accuracy of SPECT images. Several filters, including the Hanning, Butterworth, and Parzen filters, were evaluated in combination with the two reconstruction methods as well as with a specified MatLab program. Results showed that for both 3D and 4D cardiac SPECT the Butterworth filter, for different critical frequencies and orders, produced the best results. Between the two reconstruction methods, the iterative one might be more appropriate for cardiac SPECT, since it improves lesion detectability due to the significant improvement of image contrast.


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