An Evaluation of Image Noise Variance for Time-of-Flight PET

Author(s):  
C.C. Watson
2019 ◽  
Vol 86 (7-8) ◽  
pp. 422-432
Author(s):  
Daniel M. Kirchhöfer ◽  
Gerhard A. Holst ◽  
Fred S. Wouters ◽  
Stephan Hock ◽  
Bernd Jähne

AbstractToday’s camera systems used for machine vision and scientific applications have intra-scene dynamic ranges up to 16 bit and therefore A/D converters with up to 16 bit resolution per pixel. Unfortunately, the linear amplification of electrons also forces a linear or even quadratic increase of the image noise variance with the signal. Based on a method published in 2016 (B. Jähne, M. Schwarzbauer, tm-Technisches Messen 83.1), this paper describes a more general nonlinear transformation which equalizes the combined effect of temporal noise and photo-response non-uniformity (PRNU) and/or temporal noise in the illumination system of an image sensor. With this generalisation it is possible to use the equalisation also for microscopic applications for which an example is discussed.


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