This paper present a high-speed reconfigurable serial fieldbus (HRSFB) used for industry communication with baud rate up to 10Mbps and reliable communication. We developed this fieldbus based on UART (Universal Asynchronous Receiver/Transmitter) and practice it on FPGA. By using hardware programming on FPGA, we can get the high speed and make the bus reconfigurable easily. This fieldbus system includes one main node and up to 255 sub nodes, and all the nodes can automatically identified and configured at the beginning of the system which makes the field bus system shrink or expand easily. Also hardware CRC technology and ask/answer mode are used in the communication protocol to guarantee the security of the communication. This bus has been widely used in many fields, like PLC controller, CNC machine controller, data acquisition system and so on.