Toxicology questions frequently appear in the Intermediate FRCEM short-answer question (SAQ) paper and a general knowledge of poisoning and its associated management is required. This chapter covers the basic principles of poisoning and drug elimination. It also focuses on common toxidromes to aid diagnosis and their associated management. In addition, this chapter also provides detailed information and management for the commonest poisoning agents such as paracetamol, salicylates, tricyclic antidepressants, and carbon monoxide. Paracetamol overdose is one of the commonest presentations of poisoning to the emergency department, the treatment guidelines for which have recently changed. This chapter provides the basic pathophysiology of paracetamol toxicity and details the current management guidance.
