scholarly journals Early immune biomarkers and intermediate‐term outcomes after heart transplantation: Results of Clinical Trials in Organ Transplantation‐18

2019 ◽  
Vol 19 (5) ◽  
pp. 1518-1528 ◽  
Author(s):  
Josef Stehlik ◽  
Brian Armstrong ◽  
David A. Baran ◽  
Nancy D. Bridges ◽  
Anil Chandraker ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Heart Transplantation ◽  
Organ Transplantation ◽  
Immune Biomarkers

Combined Heart Transplantation with Other Organ Transplantation

2020 ◽  
pp. 383-401
Author(s):  
Katherine J. Kunkel ◽  
Maria Molina ◽  
Joyce Wald
Keyword(s):  
Heart Transplantation ◽  
Organ Transplantation

scholarly journals Avoidance of CNI and steroids using belatacept—Results of the Clinical Trials in Organ Transplantation 16 trial

2020 ◽  
Vol 20 (12) ◽  
pp. 3599-3608 ◽  
Author(s):  
Roslyn B. Mannon ◽  
Brian Armstrong ◽  
Peter G. Stock ◽  
Aneesh K. Mehta ◽  
Alton B. Farris ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Organ Transplantation

scholarly journals Expression of VE-Cadherin in Peritubular Endothelial Cells during Acute Rejection after Human Renal Transplantation

2007 ◽  
Vol 2007 ◽  
pp. 1-6 ◽  
Author(s):  
Ana Roussoulières ◽  
Brigitte McGregor ◽  
Lara Chalabreysse ◽  
Catherine Cerutti ◽  
Jeanne-Luce Garnier ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Renal Transplantation ◽  
Acute Rejection ◽  
Heart Transplantation ◽  
Organ Transplantation ◽  
Human Heart ◽  
Human Kidney ◽  
Serial Sections ◽  
Down Regulation

Genes involved in acute rejection (AR) after organ transplantation remain to be further elucidated. In a previous work we have demonstrated the under-expression of VE-Cadherin by endothelial cells (EC) in AR following murine and human heart transplantation. Serial sections from 15 human kidney Banff-graded transplant biopsies were examined for the presence of VE-Cadherin and CD34 staining by immunohistochemistry (no AR (n=5), AR grade IA (n=5), or AR grade IIA (n=5)). Quantification of peritubular EC staining were evaluated and results were expressed by the percentage of stained cells per surface analysed. There was no difference in CD34 staining between the 3 groups. VE-Cadherin expression was significantly reduced in AR Grade IIA when compared to no AR (P=.01) and to AR grade IA (P=.02). This study demonstrates a reduced VE-Cadherin expression by EC in AR after renal transplantation. The down-regulation of VE-Cadherin may strongly participate in human AR.

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