Eotaxin (CCL11) enhances mediator release from human basophils

Allergy ◽  
2021 ◽  
Author(s):  
Yuki Suzuki ◽  
Masao Yamaguchi ◽  
Miki Mori ◽  
Naoya Sugimoto ◽  
Maho Suzukawa ◽  
...  
Keyword(s):  
Mediator Release ◽  
Human Basophils

Mediator Release: Studies with Purified Human Basophils and Mast Cells

1983 ◽  
pp. 11-15
Author(s):  
Lawrence M. Lichtenstein ◽  
Anne Kagey-Sobotka ◽  
Donald W. Macglashan ◽  
Stephen P. Peters ◽  
Waclaw Kazimierczak ◽  
...  
Keyword(s):  
Mast Cells ◽  
Mediator Release ◽  
Release Studies ◽  
Human Basophils

scholarly journals Interleukin 5 modifies histamine release and leukotriene generation by human basophils in response to diverse agonists.

1990 ◽  
Vol 172 (6) ◽  
pp. 1577-1582 ◽  
Author(s):  
S C Bischoff ◽  
T Brunner ◽  
A L De Weck ◽  
C A Dahinden
Keyword(s):  
Histamine Release ◽  
De Novo ◽  
Mediator Release ◽  
Leukotriene C4 ◽  
Interleukin 5 ◽  
Low Concentrations ◽  
Inflammatory Processes ◽  
Stimulating Factor ◽  
Human Basophils ◽  
Granule Release

Human interleukin 5 (IL-5), known as a selective colony-stimulating factor of the eosinophil lineage and activator of mature eosinophils, also profoundly influences the mediator release profile of human basophils. IL-5 by itself triggers neither granule release nor de novo synthesis of lipid mediators. However, at low concentrations (0.1-10 ng/ml), IL-5 rapidly primes basophils for enhanced histamine release and leukotriene C4 (LTC4) generation in response to all established basophil agonists. LTC4 generation is more strongly affected by IL-5 than histamine release. In particular, IL-5 renders basophils capable of producing large quantities of LTC4 in response to C5a, which, without the cytokine, induces histamine release only. Finally, IL-5 renders basophils responsive to agonists (neutrophil-activating peptide 1 and C3a), which are otherwise inefficient triggers for basophil mediator release. The effects are similar to the recently established bioactivity of IL-3 on basophils, with the exception of its influence on IgE-dependent basophil activation, which is less pronounced. Thus, IL-5 strongly modulates the function not only of eosinophils but also of basophils, the two major effector leukocyte types involved in allergic inflammatory processes, e.g., in asthma.

The Pharmacologic Control of Mediator Release from Human Basophils and Mast Cells

Respiration ◽  
1986 ◽  
Vol 50 (2) ◽  
pp. 116-122 ◽  
Author(s):  
Stephen P. Peters ◽  
Robert M. Naclerio ◽  
Robert P. Schleimer ◽  
Donald W. MacGlashan, Jr. ◽  
Ulf Pipkorn ◽  
...  
Keyword(s):  
Mast Cells ◽  
Mediator Release ◽  
Human Basophils

Modulation of mediator release from human basophils and pulmonary mast cells and macrophages by auranofin

1990 ◽  
Vol 39 (2) ◽  
pp. 285-291 ◽  
Author(s):  
Michele Columbo ◽  
Daniela Galeone ◽  
Guido Guidi ◽  
Anne Kagey-Sobotka ◽  
Lawrence M. Lichtenstein ◽  
...  
Keyword(s):  
Mast Cells ◽  
Mediator Release ◽  
Human Basophils

Lipopolysaccharide Primes Human Basophils for Enhanced Mediator Release: Requirement for Plasma Co-factor and CD14

1994 ◽  
Vol 203 (2) ◽  
pp. 1295-1301 ◽  
Author(s):  
M. Iida ◽  
K. Hirai ◽  
S. Shinohara ◽  
M. Yamaguchi ◽  
T. Takaishi ◽  
...  
Keyword(s):  
Mediator Release ◽  
Human Basophils

Role of sodium in mediator release from human basophils

1992 ◽  
Vol 89 (5) ◽  
pp. 978-986 ◽  
Author(s):  
T SMITH ◽  
F SANCHEZLEGRAND ◽  
L MCKEAN ◽  
M KUTNER ◽  
E CRAGOEJR ◽  
...  
Keyword(s):  
Mediator Release ◽  
Human Basophils

Human basophils: mediator release and cytokine production

2001 ◽  
pp. 93-122 ◽  
Author(s):  
John T. Schroeder ◽  
Donald W. MacGlashan ◽  
Lawrence M. Lichtenstein
Keyword(s):  
Cytokine Production ◽  
Mediator Release ◽  
Human Basophils

Inhibition of cytokine generation and mediator release by human basophils treated with desloratadine

2001 ◽  
Vol 31 (9) ◽  
pp. 1369-1377 ◽  
Author(s):  
J. T. Schroeder ◽  
R. P. Schleimer ◽  
L. M. Lichtenstein ◽  
W. Kreutner
Keyword(s):  
Mediator Release ◽  
Human Basophils
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