scholarly journals MiRNAs and radical prostatectomy: current data, bioinformatic analysis, and utility as predictors of tumour relapse

Andrology ◽  
2021 ◽  
Author(s):  
Maria Yu Konoshenko ◽  
Pavel P Laktionov
Keyword(s):  
Radical Prostatectomy ◽  
Bioinformatic Analysis ◽  
Current Data ◽  
Tumour Relapse

scholarly journals TP53 Inhibited AR Signaling Promote Enzalutamide Resistance in LNCaP cell

2021 ◽  
Author(s):  
Xiangyu Long ◽  
Bo Jiang ◽  
Jiyan Liu
Keyword(s):  
Lncap Cell ◽  
Bioinformatic Analysis ◽  
Current Data ◽  
Rna Seq ◽  
Lncap Cells ◽  
Rt Pcr ◽  
Interfering Rna ◽  
Genome Scale ◽  
Tp53 Protein ◽  
Knockout Gene

Abstract Background: To perform gene screening and search key knockout gene associated with enzalutamide resistance in LNCaP cells. Methods: Genome-scale CRISPR-Cas9 transfection were done to screen genes associated with enzalutamide resistance in LNCaP cells. Bioinformatic analysis of TP53 and AR expression correlated with prostate adenocarcinoma by using TCGA database. Knockout interfering RNA (shRNA) were synthesized in lentivirus and transfected into LNCaP cells by using Lipofectamine 3000. TP53 and AR detection was performed by using conventional molecular biology methods, such as western blot, RT-PCR and flow cytometer et al. Results: 27 high (NES<-1.7, P<0.01) and 26 low (NES>1.7, P<0.01) expressed genes were identified in enzalutamide resistance Cells. TP53 interacted with AR may play an important role in the development of enzalutamide resistance from PPI and RNA-seq data. Data from TCGA support that patient with TP53&AR low expression endured higher pathology stage, Gleason grades, more disease progress, recurrence, positive lymphnotes examination numbers and more abnormal bones scan results. LNCaP cell dealt with enzalutamide or with TP53 knockout showed inhibited cell cycle at G0~G1, increased apoptosis percentage and also inhibited cell proliferation. Conclusions: Current data support that TP53 protein inhabiting AR signaling promote enzalutamide resistance in LNCaP cell.

scholarly journals Quality of life evaluation of patients after radical treatment of prostate cancer

2020 ◽  
Vol 17 (3) ◽  
pp. 275-286
Author(s):  
S. O. Goldytski ◽  
P. D. Demeshko ◽  
S. A. Krasny
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Radiation Therapy ◽  
Radical Prostatectomy ◽  
Functional Results ◽  
High Dose Rate ◽  
Current Data ◽  
High Dose ◽  
Radical Treatment

The article provides an overview of the current data on the quality of life in cancer patients, as well as the functional results of radical treatment of prostate cancer. The main goal was to evaluate the functional results in patients after radical prostatectomy, combined radiation therapy, and high dose-rate brachytherapy in 8 to 12 months after treatment. The study included 148 patients treated from 2017 to 2018. The life quality was assessed by specialized questionnaire. The obtained results indicate the better functional results and a higher level of the quality of life of patients after radiation therapy, compared with radical prostatectomy.

scholarly journals Robotic Radical Prostatectomy in Patients with Previous Prostate Surgery and Radiotherapy

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Ömer Acar ◽  
Tarık Esen
Keyword(s):  
Radical Prostatectomy ◽  
Case Series ◽  
Oncologic Outcome ◽  
Functional Results ◽  
Current Data ◽  
Patient Counseling ◽  
Robot Assisted ◽  
Robotic Radical Prostatectomy ◽  
Number Of Patients

Herein, we will review the available literature about robot-assisted radical prostatectomy in patients who have undergone prostate surgery or radiotherapy. Current data about this topic consists of small case series with limited follow-up. Despite being technically demanding, robot-assisted radical prostatectomy (RARP) can be considered feasible in either setting. Prostate surgery or prostatic irradiation should not be considered as a contraindication for robot-assisted radical prostatectomy. Nevertheless, patient counseling about the possible complications and the need for reintervention is of extreme importance in this patient population. Early oncologic and functional results of RARP performed in case of radiorecurrent prostate cancer look promising. Regarding postprostate surgery RARP, some series have reported comparable results, while some have demonstrated more inferior outcomes than those of naive cases. In order to assess the exact functional and oncologic outcome of RARP in patients with previous prostate surgery and radiotherapy, studies enrolling higher number of patients and providing longer follow-up data are needed.

559: Impact of Fellowship Training on Oncological Outcomes after Radical Prostatectomy

2007 ◽  
Vol 177 (4S) ◽  
pp. 186-186
Author(s):  
Fernando J. Bianco ◽  
Andrew J. Vickers ◽  
Angel M. Serio ◽  
James A. Eastham ◽  
Eric A. Klein ◽  
...  
Keyword(s):  
Radical Prostatectomy ◽  
Fellowship Training ◽  
Oncological Outcomes

554: Prospective Comparison of Short-Term Recovery between Open and Robotic Radical Prostatectomy

2007 ◽  
Vol 177 (4S) ◽  
pp. 184-185
Author(s):  
Ryan T. Schulte ◽  
Rodney L. Dunn ◽  
Brent K. Hollenbeck ◽  
J. Stuart Wolf ◽  
James E. Montie ◽  
...  
Keyword(s):  
Radical Prostatectomy ◽  
Short Term ◽  
Robotic Radical Prostatectomy ◽  
Prospective Comparison

809: Addition of Robotic Surgery to an Established Laparoscopic Radical Prostatectomy Program: Initial Impact on Positive Surgical Margins

2007 ◽  
Vol 177 (4S) ◽  
pp. 270-270
Author(s):  
Robert A. Linden ◽  
Adeep Thumar ◽  
Danny Haddad ◽  
Steve N. Dong ◽  
Leonard G. Gomella ◽  
...  
Keyword(s):  
Robotic Surgery ◽  
Radical Prostatectomy ◽  
Laparoscopic Radical Prostatectomy ◽  
Surgical Margins ◽  
Positive Surgical Margins

942: Two-Year Outcome of Unilateral Sural Nerve Interposition Graft after Radical Prostatectomy

2007 ◽  
Vol 177 (4S) ◽  
pp. 312-312
Author(s):  
Claire C. Yang ◽  
Hong Gee Sim ◽  
Michel Kliot ◽  
Paul H. Lange ◽  
William J. Ellis ◽  
...  
Keyword(s):  
Radical Prostatectomy ◽  
Sural Nerve ◽  
Interposition Graft
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