scholarly journals Clomiphene Citrate for Men with Hypogonadism ‐ A Systematic Review & Meta‐analysis

Andrology ◽  
2021 ◽  
Author(s):  
M. Huijben ◽  
M.T.W.T Lock ◽  
V.F. Kemp ◽  
L.M.O. Kort ◽  
H.M.K Breda
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Clomiphene Citrate

Letrozole versus clomiphene citrate in polycystic ovary syndrome: systematic review and meta-analysis

2015 ◽  
Vol 31 (12) ◽  
pp. 917-921 ◽  
Author(s):  
Matheus Roque ◽  
Ana C. I. Tostes ◽  
Marcello Valle ◽  
Marcos Sampaio ◽  
Selmo Geber
Keyword(s):  
Systematic Review ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Meta Analysis ◽  
Clomiphene Citrate ◽  
Ovary Syndrome

scholarly journals Effect of clomiphene citrate on endometrial thickness, ovulation, pregnancy and live birth in anovulatory women: systematic review and meta-analysis

2017 ◽  
Vol 51 (1) ◽  
pp. 64-76 ◽  
Author(s):  
M. A. Gadalla ◽  
S. Huang ◽  
R. Wang ◽  
R. J. Norman ◽  
S. A. Abdullah ◽  
...  
Keyword(s):  
Systematic Review ◽  
Live Birth ◽  
Endometrial Thickness ◽  
Meta Analysis ◽  
Clomiphene Citrate

Letrozole versus clomiphene citrate for unexplained infertility: A systematic review and meta-analysis

2014 ◽  
Vol 40 (5) ◽  
pp. 1205-1216 ◽  
Author(s):  
Aihai Liu ◽  
Chao Zheng ◽  
Junzhe Lang ◽  
Wenbing Chen
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Clomiphene Citrate ◽  
Unexplained Infertility

Luteal phase clomiphene citrate for ovulation induction in women with polycystic ovary syndrome: a systematic review and meta-analysis

2016 ◽  
Vol 32 (11) ◽  
pp. 866-871 ◽  
Author(s):  
Nan Ding ◽  
Jianbo Chang ◽  
Qiliang Jian ◽  
Xuefei Liang ◽  
Zhongzhen Liang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Polycystic Ovary Syndrome ◽  
Luteal Phase ◽  
Ovulation Induction ◽  
Polycystic Ovary ◽  
Meta Analysis ◽  
Clomiphene Citrate ◽  
Ovary Syndrome

scholarly journals Letrozole versus clomiphene citrate for unexplained infertility: a systematic review and meta-analysis of randomized, controlled trials

2018 ◽  
Vol 110 (4) ◽  
pp. e248
Author(s):  
A.M. Eskew ◽  
B. Bedrick ◽  
C. Stoll ◽  
A. Hardi ◽  
M.G. Tuuli ◽  
...  
Keyword(s):  
Systematic Review ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Clomiphene Citrate ◽  
Unexplained Infertility ◽  
Controlled Trials ◽  
Randomized Controlled

scholarly journals Adjuvant treatment strategies in ovarian stimulation for poor responders undergoing IVF: a systematic review and network meta-analysis

2020 ◽  
Vol 26 (2) ◽  
pp. 247-263 ◽  
Author(s):  
Yu Zhang ◽  
Chao Zhang ◽  
Jing Shu ◽  
Jing Guo ◽  
Hsun-Ming Chang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Adjuvant Treatment ◽  
Ovarian Stimulation ◽  
Meta Analysis ◽  
Clomiphene Citrate ◽  
Treatment Strategies ◽  
Systemic Review ◽  
Poor Responders ◽  
Controlled Trials ◽  
Cochrane Central Register

ABSTRACT BACKGROUND Despite great advances in assisted reproductive technology, poor ovarian response (POR) is still considered as one of the most challenging tasks in reproductive medicine. OBJECTIVE AND RATIONALE The aim of this systemic review is to evaluate the role of different adjuvant treatment strategies on the probability of pregnancy achievement in poor responders undergoing IVF. Randomized controlled trials (RCTs) comparing 10 adjuvant treatments [testosterone, dehydroepiandrosterone (DHEA), letrozole, recombinant LH, recombinant hCG, oestradiol, clomiphene citrate, progesterone, growth hormone (GH) and coenzyme Q10 (CoQ10)] were included. SEARCH METHODS Relevant studies published in the English language were comprehensively selected using PubMed, Embase and the Cochrane Central Register of Controlled Trials (CENTRAL) until 11 July 2018. We included studies that investigated various adjuvant agents, including androgen and androgen-modulating agents, oestrogen, progesterone, clomiphene citrate, GH and CoQ10, during IVF treatment and reported subsequent pregnancy outcomes. The administration of GnRH analogs and gonadotrophins without adjuvant treatment was set as the control. We measured study quality based on the methodology and categories listed in the Cochrane Collaboration Handbook. This review protocol was registered with PROSPERO (CRD42018086217). OUTCOMES Of the 1124 studies initially identified, 46 trials reporting on 6312 women were included in this systematic review, while 19 trials defining POR using the Bologna criteria reporting 2677 women were included in the network meta-analysis. Compared with controls, DHEA and CoQ10 treatments resulted in a significantly higher chance of clinical pregnancy [odds ratio (OR) 2.46, 95% CI 1.16 to 5.23; 2.22, 1.08–4.58, respectively]. With regard to the number of retrieved oocytes, HCG, oestradiol and GH treatments had the highest number of oocytes retrieved [weighted mean difference (WMD) 2.08, 0.72 to 3.44; 2.02, 0.23 to 3.81; 1.72, 0.98 to 2.46, compared with controls, respectively]. With regard to the number of embryos transferred, testosterone and GH treatment led to the highest number of embryos transferred (WMD 0.72, 0.11 to 1.33; 0.67, 0.43 to 0.92; compared with controls, respectively). Moreover, GH resulted in the highest oestradiol level on the HCG day (WMD 797.63, 466.45 to 1128.81, compared with controls). Clomiphene citrate, letrozole and GH groups used the lowest dosages of gonadotrophins for ovarian stimulation (WMD 1760.00, −2890.55 to −629.45; −1110.17, −1753.37 to −466.96; −875.91, −1433.29 to −282.52; compared with controls, respectively). CoQ10 led to the lowest global cancelation rate (OR 0.33, 0.15 to 0.74, compared with controls). WIDER IMPLICATIONS For patients with POR, controlled ovarian stimulation protocols using adjuvant treatment with DHEA, CoQ10 and GH showed better clinical outcomes in terms of achieving pregnancy, and a lower dosage of gonadotrophin required for ovulation induction. Furthermore, high-level RCT studies using uniform standards for POR need to be incorporated into future meta-analyses.

Higher ovulation rate with letrozole as compared with clomiphene citrate in infertile women with polycystic ovary syndrome: a systematic review and meta-analysis

HORMONES ◽  
2021 ◽  
Author(s):  
Alexandra P. Tsiami ◽  
Dimitrios G. Goulis ◽  
Alexandros I. Sotiriadis ◽  
Efstratios M. Kolibianakis
Keyword(s):  
Systematic Review ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Meta Analysis ◽  
Clomiphene Citrate ◽  
Ovulation Rate ◽  
Ovary Syndrome ◽  
Infertile Women

scholarly journals Systematic review and meta-analysis of letrozole and clomiphene citrate in polycystic ovary syndrome

2018 ◽  
Vol 23 (3) ◽  
pp. 163-170
Author(s):  
Abdul Qadr Akinoso-Imran ◽  
Hamed Adetunji
Keyword(s):  
Systematic Review ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Meta Analysis ◽  
Clomiphene Citrate ◽  
Ovary Syndrome
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