scholarly journals Optimizing porcine donor kidney preservation with normothermic or hypothermic machine perfusion: A systematic review

2021 ◽  
Author(s):  
Sarah Bouari ◽  
Özgür Eryigit ◽  
Ron W. F. Bruin ◽  
Jan N. M. IJzermans ◽  
Robert C. Minnee
Keyword(s):  
Systematic Review ◽  
Machine Perfusion ◽  
Donor Kidney ◽  
Kidney Preservation ◽  
Hypothermic Machine Perfusion

Hypothermic machine perfusion in deceased donor kidney transplantation: a systematic review

2013 ◽  
Vol 180 (1) ◽  
pp. 176-182 ◽  
Author(s):  
Vincent W.T. Lam ◽  
Jerome M. Laurence ◽  
Arthur J. Richardson ◽  
Henry C.C. Pleass ◽  
Richard D.M. Allen
Keyword(s):  
Systematic Review ◽  
Kidney Transplantation ◽  
Deceased Donor ◽  
Machine Perfusion ◽  
Donor Kidney ◽  
Hypothermic Machine Perfusion ◽  
Deceased Donor Kidney ◽  
Donor Kidney Transplantation ◽  
Deceased Donor Kidney Transplantation

scholarly journals The Effects of 6-Chromanol SUL-138 during Hypothermic Machine Perfusion on Porcine Deceased Donor Kidneys

2021 ◽  
Vol 2 (3) ◽  
pp. 304-314
Author(s):  
L. Annick van Furth ◽  
Leonie H. Venema ◽  
Koen D. W. Hendriks ◽  
Pieter C. Vogelaar ◽  
Guido Krenning ◽  
...  
Keyword(s):  
Renal Function ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Autologous Blood ◽  
Warm Ischemia ◽  
Protective Agent ◽  
Machine Perfusion ◽  
Kidney Preservation ◽  
Atp Levels ◽  
Hypothermic Machine Perfusion

Diminishing ischemia-reperfusion injury (IRI) by improving kidney preservation techniques offers great beneficial value for kidney transplant recipients. Mitochondria play an important role in the pathogenesis of IRI and are therefore interesting targets for pharmacological interventions. Hypothermic machine perfusion (HMP), as a preservation strategy, offers the possibility to provide mitochondrial–targeted therapies. This study focuses on the addition of a mitochondrial protective agent SUL—138 during HMP and assesses its effect on kidney function and injury during normothermic reperfusion. In this case, 30 min of warm ischemia was applied to porcine slaughterhouse kidneys before 24 h of non–oxygenated HMP with or without the addition of SUL—138. Functional assessment was performed by 4 h normothermic autologous blood reperfusion. No differences in renal function or perfusion parameters were found between both groups. ATP levels were lower after 30 min of warm ischemia in the SUL–138 group (n.s, p = 0.067) but restored significantly during 24 h of HMP in combination with SUL—138. Aspartate aminotransferase (ASAT) levels were significantly lower for the SUL—138 group. SUL—138 does not influence renal function in this model. Restoration of ATP levels during 24 h of HMP with the addition of SUL in combination with lower ASAT levels could be an indication of improved mitochondrial function.

Effectivity of Hypothermic Machine Perfusion Preservation for Non-Heart-Beating Donor Kidney Transplantation in Japan

2018 ◽  
Vol 102 ◽  
pp. S790
Author(s):  
Naotake Akutsu ◽  
Michihiro Maruyama ◽  
Kazunori Otsuki ◽  
Kenichi Saigo ◽  
Hiromichi Aoyama ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Machine Perfusion ◽  
Donor Kidney ◽  
Hypothermic Machine Perfusion ◽  
Heart Beating ◽  
Donor Kidney Transplantation

The effect of hypothermic machine perfusion and cold storage for kidney preservation

2017 ◽  
Author(s):  
Yanee Chusri ◽  
Goragoch Gesprasert ◽  
Thananya Khienwad ◽  
Phornphop Naiyanate
Keyword(s):  
Cold Storage ◽  
Machine Perfusion ◽  
Kidney Preservation ◽  
Hypothermic Machine Perfusion

scholarly journals Oxygenated End-Hypothermic Machine Perfusion in Expanded Criteria Donor Kidney Transplant

JAMA Surgery ◽  
2021 ◽  
Author(s):  
Peri Husen ◽  
Catherine Boffa ◽  
Ina Jochmans ◽  
Christina Krikke ◽  
Lucy Davies ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Machine Perfusion ◽  
Donor Kidney ◽  
Expanded Criteria Donor ◽  
Hypothermic Machine Perfusion ◽  
Expanded Criteria

scholarly journals A systematic review to identify whether perfusate biomarkers produced during hypothermic machine perfusion can predict graft outcomes in kidney transplantation

2020 ◽  
Vol 33 (6) ◽  
pp. 590-602 ◽  
Author(s):  
Francesco Guzzi ◽  
Simon R. Knight ◽  
Rutger J. Ploeg ◽  
James P. Hunter
Keyword(s):  
Systematic Review ◽  
Kidney Transplantation ◽  
Machine Perfusion ◽  
Hypothermic Machine Perfusion
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