scholarly journals Consensus: guidelines: best practices for detection, assessment and management of suspected acute drug-induced liver injury during clinical trials in patients with nonalcoholic steatohepatitis

2019 ◽  
Vol 49 (6) ◽  
pp. 702-713 ◽  
Author(s):  
Arie Regev ◽  
Melissa Palmer ◽  
Mark I. Avigan ◽  
Lara Dimick-Santos ◽  
William R. Treem ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Liver Injury ◽  
Best Practices ◽  
Nonalcoholic Steatohepatitis ◽  
Consensus Guidelines ◽  
Drug Induced ◽  
Drug Induced Liver Injury

scholarly journals Prevention and management of idiosyncratic drug-induced liver injury: Systematic review and meta-analysis of randomised clinical trials

2021 ◽  
Vol 164 ◽  
pp. 105404
Author(s):  
Hao Niu ◽  
Judith Sanabria-Cabrera ◽  
Ismael Alvarez-Alvarez ◽  
Mercedes Robles-Diaz ◽  
Simona Stankevičiūtė ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Liver Injury ◽  
Meta Analysis ◽  
Randomised Clinical Trials ◽  
Drug Induced ◽  
Drug Induced Liver Injury

Using controlled clinical trials to learn more about acute drug-induced liver injury

Hepatology ◽  
2008 ◽  
Vol 48 (5) ◽  
pp. 1680-1689 ◽  
Author(s):  
Paul B. Watkins ◽  
Paul J. Seligman ◽  
John S. Pears ◽  
Mark I. Avigan ◽  
John R. Senior
Keyword(s):  
Clinical Trials ◽  
Liver Injury ◽  
Controlled Clinical Trials ◽  
Drug Induced ◽  
Drug Induced Liver Injury

Variation in Liver Biochemistries in Patients with Decompensated Cirrhosis: Implications for Assessing Drug-Induced Liver Injury in Clinical Trials

2016 ◽  
Vol 30 (2) ◽  
pp. 95-101 ◽  
Author(s):  
Marzena Jurek ◽  
Masoud Mokhtarani ◽  
John M. Vierling ◽  
Dion F. Coakley ◽  
Jitendra Ganju ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Liver Injury ◽  
Decompensated Cirrhosis ◽  
Drug Induced ◽  
Drug Induced Liver Injury

scholarly journals Assessing Toxicity in Drug Trials in Liver Disease

2021 ◽  
Author(s):  
Morris Sherman
Keyword(s):  
Clinical Trials ◽  
Liver Disease ◽  
Liver Injury ◽  
Viral Hepatitis ◽  
Liver Diseases ◽  
New Drugs ◽  
Drug Trials ◽  
Drug Induced ◽  
Drug Induced Liver Injury

AbstractSince the early trials in viral hepatitis, more and more new drugs are being tested for use in various liver diseases. Since drug hepatotoxicity is a major cause of drugs under investigation not making it to market, the assessment of drug-induced liver injury in clinical trials of new drugs is crucial. This review will focus on the systems that are used to assess drug-induced liver injury in clinical trials and will discuss how some of these criteria are inappropriate or inaccurate in this function together with suggestions for improvement.

Drug-induced liver injury: Asia Pacific Association of Study of Liver consensus guidelines

2021 ◽  
Author(s):  
Harshad Devarbhavi ◽  
◽  
Guruprasad Aithal ◽  
Sombat Treeprasertsuk ◽  
Hajime Takikawa ◽  
...  
Keyword(s):  
Liver Injury ◽  
Asia Pacific ◽  
Consensus Guidelines ◽  
Drug Induced ◽  
Drug Induced Liver Injury
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