Assessing Toxicity in Drug Trials in Liver Disease
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AbstractSince the early trials in viral hepatitis, more and more new drugs are being tested for use in various liver diseases. Since drug hepatotoxicity is a major cause of drugs under investigation not making it to market, the assessment of drug-induced liver injury in clinical trials of new drugs is crucial. This review will focus on the systems that are used to assess drug-induced liver injury in clinical trials and will discuss how some of these criteria are inappropriate or inaccurate in this function together with suggestions for improvement.
2018 ◽
pp. 431-457
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2019 ◽
Vol 51
(1)
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pp. 90-109
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2016 ◽
Vol 151
(6)
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pp. 1046-1051
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2017 ◽
Vol 11
(2)
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pp. 440-445
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Keyword(s):
2018 ◽
Vol 15
(1)
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pp. 90-95
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2010 ◽
pp. 2527-2537
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2019 ◽
Vol 7
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pp. 232470961983613
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