scholarly journals Autoimmune cytopenias in patients with chronic lymphocytic leukaemia treated with ibrutinib in routine clinical practice at an academic medical centre

2018 ◽  
Vol 183 (3) ◽  
pp. 421-427 ◽  
Author(s):  
Paul J. Hampel ◽  
Melissa C. Larson ◽  
Brian Kabat ◽  
Timothy G. Call ◽  
Wei Ding ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Chronic Lymphocytic Leukaemia ◽  
Lymphocytic Leukaemia ◽  
Routine Clinical Practice ◽  
Medical Centre ◽  
Academic Medical Centre ◽  
Academic Medical ◽  
Autoimmune Cytopenias

scholarly journals Where is the leak in the pipeline? Investigating gender differences in academic promotion at an academic medical centre

2016 ◽  
Vol 5 (2) ◽  
pp. 125-128 ◽  
Author(s):  
Jessica K. Paulus ◽  
Karen M. Switkowski ◽  
Geneve M. Allison ◽  
Molly Connors ◽  
Rachel J. Buchsbaum ◽  
...  
Keyword(s):  
Gender Differences ◽  
Medical Centre ◽  
Academic Medical Centre ◽  
Academic Promotion ◽  
Academic Medical

Assessing and improving safety culture throughout an academic medical centre: a prospective cohort study

2010 ◽  
Vol 19 (6) ◽  
pp. 547-554 ◽  
Author(s):  
L. A. Paine ◽  
B. J. Rosenstein ◽  
J. B. Sexton ◽  
P. Kent ◽  
C. G. Holzmueller ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Safety Culture ◽  
Prospective Cohort ◽  
Medical Centre ◽  
Academic Medical Centre ◽  
Academic Medical

scholarly journals Echinocandin resistance among Candida isolates at an academic medical centre 2005–15: analysis of trends and outcomes

2018 ◽  
Vol 73 (6) ◽  
pp. 1677-1680 ◽  
Author(s):  
Todd P McCarty ◽  
Shawn R Lockhart ◽  
Stephen A Moser ◽  
Jennifer Whiddon ◽  
Joanna Zurko ◽  
...  
Keyword(s):  
Medical Centre ◽  
Academic Medical Centre ◽  
Academic Medical ◽  
Echinocandin Resistance

Chronic lymphocytic leukaemia

2020 ◽  
pp. 5302-5310
Author(s):  
Clive S. Zent ◽  
Aaron Polliack
Keyword(s):  
Bone Marrow ◽  
Chronic Lymphocytic Leukaemia ◽  
B Cell ◽  
Peripheral Blood ◽  
B Lymphocyte ◽  
Lymphocytic Leukaemia ◽  
Bone Marrow Failure ◽  
Curative Therapy ◽  
Symptomatic Disease ◽  
Autoimmune Cytopenias

Chronic lymphocytic leukaemia (CLL)/small lymphocytic lymphoma is the most prevalent lymphoid neoplasm in Europe and North America. The ‘cell of origin’ is a mature B lymphocyte with a rearranged immunoglobulin gene. CLL cells express modest amounts of surface immunoglobulin, and are characterized by defective apoptosis. The cause of CLL is unknown. Most patients show no specific clinical features of disease and are diagnosed during evaluation of an incidental finding of peripheral blood lymphocytosis, lymphadenopathy, or splenomegaly. A small percentage of patients (<10%) present with symptomatic disease resulting from (1) tissue accumulation of lymphocytes such as disfiguring lymphadenopathy, splenomegaly with abdominal discomfort, profound fatigue, drenching night sweats, weight loss, and fever; or (2) manifestations of marrow failure with cytopenias including anaemia and thrombocytopenia. All CLL patients have an increased risk of infection, autoimmune cytopenias, and second haematological (e.g. diffuse large B-cell lymphoma) and nonhaematological malignancies. Diagnosis is usually made by analysis of the immunophenotype of the monoclonal circulating cells in the peripheral blood. In patients with the small lymphocytic variant of CLL without a detectable circulating monoclonal B-cell population, the diagnosis is made using tissue from the bone marrow, lymph nodes, or spleen. Treatment—there is no standard curative therapy and patients should not be treated until they have progressive and symptomatic disease or develop anaemia or thrombocytopenia due to bone marrow failure. If a decision is made to treat, then the best initial treatment should be given, based on evaluation of the patient’s disease characteristics with specific attention to the integrity of TP53 (coding for p53) and patient fitness.

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