Role of epigenetics in parturition and preterm birth

2021 ◽  
Author(s):  
Chunjin Li ◽  
Maosheng Cao ◽  
Xu Zhou
Keyword(s):  
Preterm Birth

scholarly journals Oral melatonin as a new tool for neuroprotection in preterm newborns: study protocol for a randomized controlled trial

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Francesca Garofoli ◽  
Stefania Longo ◽  
Camilla Pisoni ◽  
Patrizia Accorsi ◽  
Micol Angelini ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Preterm Infants ◽  
Neurodevelopmental Outcome ◽  
Lipid Peroxidation Product ◽  
Cerebral Magnetic Resonance Imaging ◽  
Neurodevelopmental Impairment ◽  
Anti Oxidant ◽  
Preterm Newborns

Abstract Background Prevention of neurodevelopmental impairment due to preterm birth is a major health challenge. Despite advanced obstetric and neonatal care, to date there are few neuroprotective molecules available. Melatonin has been shown to have anti-oxidant/anti-inflammatory effects and to reduce brain damage, mainly after hypoxic ischemic encephalopathy. The planned study will be the first aiming to evaluate the capacity of melatonin to mitigate brain impairment due to premature birth. Method In our planned prospective, multicenter, double-blind, randomized vs placebo study, we will recruit, within 96 h of birth, 60 preterm newborns with a gestational age ≤ 29 weeks + 6 days; these infants will be randomly allocated to oral melatonin, 3 mg/kg/day, or placebo for 15 days. After the administration period, we will measure plasma levels of malondialdehyde, a lipid peroxidation product considered an early biological marker of melatonin treatment efficacy (primary outcome). At term-equivalent age, we will evaluate neurological status (through cerebral ultrasound, cerebral magnetic resonance imaging, vision and hearing evaluations, clinical neurological assessment, and screening for retinopathy of prematurity) as well as the incidence of bronchodysplasia and sepsis. We will also monitor neurodevelopmental outcome during the first 24 months of corrected age (using the modified Fagan Test of Infant Intelligence at 4–6 months and standardized neurological and developmental assessments at 24 months). Discussion Preterm birth survivors often present long-term neurodevelopmental sequelae, such as motor, learning, social-behavioral, and communication problems. We aim to assess the role of melatonin as a neuroprotectant during the first weeks of extrauterine life, when preterm infants are unable to produce it spontaneously. This approach is based on the supposition that its anti-oxidant mechanism could be useful in preventing neurodevelopmental impairment. Considering the short- and long-term morbidities related to preterm birth, and the financial and social costs of the care of preterm infants, both at birth and over time, we suggest that melatonin administration could lead to considerable saving of resources. This would be the first study addressing the role of melatonin in very low birth weight preterm newborns, and it could provide a basis for further studies on melatonin as a neuroprotection strategy in this vulnerable population. Trial registration ClinicalTrials.gov NCT04235673. Prospectively registered on 22 January 2020.

Role of progesterone, cerclage and pessary in preventing preterm birth in twin pregnancies: A systematic review and network meta-analysis

2021 ◽  
Vol 261 ◽  
pp. 166-177
Author(s):  
Francesco D’Antonio ◽  
Vincenzo Berghella ◽  
Daniele Di Mascio ◽  
Gabriele Saccone ◽  
Filomena Sileo ◽  
...  
Keyword(s):  
Systematic Review ◽  
Preterm Birth ◽  
Meta Analysis ◽  
Twin Pregnancies

scholarly journals The Role of Preterm Birth in the Association Between Opioid Maintenance Therapy and Neonatal Abstinence Syndrome

2018 ◽  
Vol 32 (2) ◽  
pp. 213-222 ◽  
Author(s):  
Lara S. Lemon ◽  
Ashley Naimi ◽  
Steve N. Caritis ◽  
Robert W. Platt ◽  
Raman Venkataramanan ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Maintenance Therapy ◽  
Neonatal Abstinence Syndrome ◽  
Abstinence Syndrome ◽  
Opioid Maintenance Therapy

scholarly journals The Role of Socioeconomic Factors in Black–White Disparities in Preterm Birth

2015 ◽  
Vol 105 (4) ◽  
pp. 694-702 ◽  
Author(s):  
Paula A. Braveman ◽  
Katherine Heck ◽  
Susan Egerter ◽  
Kristen S. Marchi ◽  
Tyan Parker Dominguez ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Socioeconomic Factors

scholarly journals Role of Cervical Cerclage and Vaginal Progesterone in the Treatment of Cervical Incompetence with/without Preterm Birth History

2016 ◽  
Vol 129 (22) ◽  
pp. 2670-2675 ◽  
Author(s):  
Shao-Wei Wang ◽  
Lin-Lin Ma ◽  
Shuai Huang ◽  
Lin Liang ◽  
Jun-Rong Zhang
Keyword(s):  
Preterm Birth ◽  
Cervical Cerclage ◽  
Birth History ◽  
Cervical Incompetence ◽  
Vaginal Progesterone

The Role of Social Support in the Prevention of Preterm Birth

Birth ◽  
1988 ◽  
Vol 15 (1) ◽  
pp. 19-23 ◽  
Author(s):  
Robert L. Bryce ◽  
Fiona J. Stanley ◽  
Murray W. Enkin
Keyword(s):  
Social Support ◽  
Preterm Birth

The Influence of Pre-natal Supplement Initiation on Preterm Birth Among Majority Hispanic Women in Los Angeles County: The Role of Nativity

2016 ◽  
Vol 20 (9) ◽  
pp. 1861-1868 ◽  
Author(s):  
Vivian H. Alfonso ◽  
Ondine von Ehrenstein ◽  
Gretchen Bandoli ◽  
Beate Ritz
Keyword(s):  
Preterm Birth ◽  
Los Angeles ◽  
Los Angeles County ◽  
Hispanic Women

The role of infection in the etiology of preterm birth

1989 ◽  
Vol 28 (2) ◽  
pp. 198-198
Author(s):  
M Toth ◽  
SS Witkin ◽  
W Ledger ◽  
H Thaler
Keyword(s):  
Preterm Birth
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