Abstract
Background and Aims
Glomerulonephritis (GN) is a major cause of end stage renal disease (ESRD)1.
It represents the primary cause of end stage renal disease (ESRD) for 25% of the dialysis population1 and 45% of the transplant population.
For patients with GN requiring renal replacement therapy, kidney transplantation is associated with superior outcomes compared with dialysis2.
The possibility of recurrence of the original disease after transplantation was described in a seminal paper more than 40 years ago, and it is now clear that all forms of GN may recur after kidney transplantation.3
To study the recurrence of glomerulonephritis post-transplant in a tertiary care centre.
Method
120 renal transplant recipients were analyzed from September 2015 to August 2019 at the Institute of Nephro-Urology, Bangalore.
It was a retrospective analysis of data
Results
120 adult patients underwent kidney transplantation, out of these 70 had GN as primary cause of kidney disease.
85.8% were males, 14.2 % females.
58.9 % were biopsy proven GN, remaining 41.1 % diagnosed based on history and clinical presentation.
All but one patient had their first transplant.
Out of these kidney transplant recipients 08 (11.4%) had recurrence of GN. From these 4/08 was recurrent IgA N, 2/08 were PGNMID, 1/08 MGN, 1/08 aHUS. Graft loss due to recurrent GN was seen in 1/08 patients (12.5%).
Conclusion
Our study showed that 11.4 % of kidney transplant recipients with GN as their cause of ESRD had recurrent GN post kidney transplantation. IgAN was the most type of GN that recurred most frequently followed by PGNMID. Recurrence of GN was in par with other studies and did not affect graft survival
Re: Hepatitis C virus infection in end-stage renal disease and kidney transplantation
