scholarly journals Differences of Adrenal‐derived Androgens in 5α‐reductase Deficiency versus Androgen Insensitivity Syndrome

2021 ◽  
Author(s):  
Bing Han ◽  
Hui Zhu ◽  
Haijun Yao ◽  
Jianwei Ren ◽  
Patrick O’Day ◽  
...  
Keyword(s):  
Androgen Insensitivity Syndrome ◽  
Androgen Insensitivity ◽  
Reductase Deficiency ◽  
5Α Reductase Deficiency

Evidence for secondary 5α-reductase deficiency in genital and supra-pubic skin of subjects with androgen insensitivity syndrome

1988 ◽  
Vol 117 (3) ◽  
pp. 353-360 ◽  
Author(s):  
S. C. Wilson ◽  
R. E. Oakey ◽  
J. S. Scott
Keyword(s):  
Reductase Activity ◽  
Hydroxysteroid Dehydrogenase ◽  
Androgen Insensitivity Syndrome ◽  
Metabolizing Enzymes ◽  
Complete Androgen Insensitivity Syndrome ◽  
Androgen Insensitivity ◽  
Reductase Deficiency ◽  
Factors Associated ◽  
Skin Homogenate ◽  
5Α Reductase Deficiency

Abstract. The activity of 5 in genital and supra-pubic skin (homogenate or fibroblasts) from subjects with complete or incomplete androgen insensitivity syndrome was low compared with mean activity in samples from normally differentiated male controls. Also, in two subjects with incomplete androgen insensitivity syndrome the ratio of the concentration of testosterone to that of 5α-dihydrotestosterone in plasma was raised after hCG stimulation but normal under basal conditions. In three subjects with complete androgen insensitivity syndrome there was no evidence of raised ratios of testosterone to 5α-dihydrotestosterone in plasma under basal or hCG-stimulated conditions. The activities of other steroid metabolizing enzymes, e.g. 17β-hypdroxysteroid dehydrogenase, 3α/β-hydroxysteroid dehydrogenase, were not decreased. The low 5α-reductase activity of androgen insensitive subjects reported here, and by others, may imply that this enzyme in genital skin is in some way androgen dependent, or responsive to other factors associated with androgen insensitivity syndrome.

5α-Reductase activity of genital and nongenital skin fibroblasts from patients with 5α-reductase deficiency, androgen insensitivity, or unknown forms of male pseudohermaphroditism

1978 ◽  
Vol 1 (4) ◽  
pp. 407-416 ◽  
Author(s):  
Leonard Pinsky ◽  
Morris Kaufman ◽  
Cipia Straisfeld ◽  
Barbara Zilahi ◽  
Conrad St.-G. Hall ◽  
...  
Keyword(s):  
Reductase Activity ◽  
Skin Fibroblasts ◽  
Male Pseudohermaphroditism ◽  
Androgen Insensitivity ◽  
Reductase Deficiency ◽  
5Α Reductase Deficiency

Hormonal Evaluation of a Large Kindred with Complete Androgen Insensitivity: Evidence for Secondary 5α-Reductase Deficiency*

1982 ◽  
Vol 54 (5) ◽  
pp. 931-941 ◽  
Author(s):  
JULIANNE IMPERATO-MCGINLEY ◽  
RALPH E. PETERSON ◽  
TEOFILO GAUTIER ◽  
GEORGE COOPER ◽  
ROBERT DANNER ◽  
...  
Keyword(s):  
Androgen Insensitivity ◽  
Reductase Deficiency ◽  
Hormonal Evaluation ◽  
5Α Reductase Deficiency

Abstract #902: The Wide Spectrum of Androgen Insensitivity Syndrome

2015 ◽  
Vol 21 ◽  
pp. 178
Author(s):  
Shwetha Mallesara Sudhakar ◽  
Shahla Nadereftekhari
Keyword(s):  
Wide Spectrum ◽  
Androgen Insensitivity Syndrome ◽  
Androgen Insensitivity
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