Role of epigenetic regulatory enzymes in animal models of mania induced by amphetamine and paradoxical sleep deprivation

2020 ◽  
Author(s):  
Roger B Varela ◽  
Wilson R Resende ◽  
Gustavo C Dal‐Pont ◽  
Fernanda F Gava ◽  
Gabriella B Nadas ◽  
...  
Keyword(s):  
Animal Models ◽  
Sleep Deprivation ◽  
Paradoxical Sleep ◽  
Paradoxical Sleep Deprivation ◽  
Regulatory Enzymes

scholarly journals Role of Orexin 1 Receptor Blocker SB-334867 On Changes Of Triglyceride And Cholesterol Metabolisminduced By Paradoxical Sleep Deprivation In Adult Male Rats

2019 ◽  
Vol 23 (2) ◽  
pp. 1-6
Author(s):  
Hoda Ahmed ◽  
Ahmed Mahmoud ◽  
Mohammed Ahmed ◽  
Khaled Abdel-Sater
Keyword(s):  
Sleep Deprivation ◽  
Adult Male ◽  
Paradoxical Sleep ◽  
Male Rats ◽  
Receptor Blocker ◽  
Paradoxical Sleep Deprivation

Author response for "Role of epigenetic regulatory enzymes in animal models of mania induced by amphetamine and paradoxal sleep deprivation"

2020 ◽  
Author(s):  
Roger B Varela ◽  
Wilson R Resende ◽  
Gustavo C Dal‐Pont ◽  
Fernanda F Gava ◽  
Gabriella B Nadas ◽  
...  
Keyword(s):  
Animal Models ◽  
Sleep Deprivation ◽  
Author Response ◽  
Regulatory Enzymes

scholarly journals SLEEP DEPRIVATION INTERFERES WITH JAK/STAT SIGNALING PATHWAY AND MYOGENESIS IN MASSETER MUSCLE OF RATS

2021 ◽  
Author(s):  
Marina Gomes Galvani ◽  
Hanna Karen Moreira Antunes ◽  
Marcos Monico-Neto ◽  
Veronica Quispe Yujra ◽  
Carla Maximo Prado ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Signaling Pathway ◽  
Masseter Muscle ◽  
Paradoxical Sleep ◽  
Paradoxical Sleep Deprivation ◽  
Cellular Density ◽  
Stat Signaling ◽  
Male Wistar Rats ◽  
Profile Area

jectives. This study evaluated the JAK/STAT signaling pathway and myogenesis on masseter muscle after sleep deprivation as well as to investigate the role of stress in this scenario. Subjetcts and Methods. A total of 18 male Wistar rats were distributed into the following groups: Control (CTRL; n=6): animals were not submitted to any procedures; Sleep Deprivation and Vehicle (PSD+V; n=6): animals were subjected to Paradoxical Sleep Deprivation for 96h and (PSD+MET; n=6): animals were subjected to Paradoxical Sleep Deprivation for 96h with administration of metyrapone. Paradoxal Sleep deprivation was performed by the Modified Multiple Platforms Method. Histopatological analysis, histomorphmetry and immunohistochemistry were performed. Results and Conclusion. The results showed the presence of inflammatory infiltrate in the PSD+V and PSD+MET groups and atrophy. Histomorphometry showed that Cellular Profile Area decreased while Cellular Density increased in both experimental groups. Expression of p-STAT 3, MyoD and MyoG increased in PSD+V group, while the PSD+MET group increased expression of IL-6 and p-STAT 3. Our results are consistent with notion that sleep deprivation induced inflammatory response and atrophy in masseter muscle of rats.

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