Responsive neurostimulation for regional neocortical epilepsy

Epilepsia ◽  
2019 ◽  
Vol 61 (1) ◽  
pp. 96-106 ◽  
Author(s):  
Brandy B. Ma ◽  
Madeline C. Fields ◽  
Robert C. Knowlton ◽  
Edward F. Chang ◽  
Jerzy P. Szaflarski ◽  
...  
Keyword(s):  
Neocortical Epilepsy

Eloquent and epileptogenic brain: advantages of navigated brain stimulation in focal neocortical epilepsy?

2009 ◽  
Vol 40 (01) ◽  
Author(s):  
S Schmidt ◽  
E Holst ◽  
K Irlbacher ◽  
M Merschhemke ◽  
SA Brandt
Keyword(s):  
Brain Stimulation ◽  
Navigated Brain Stimulation ◽  
Neocortical Epilepsy

Outcome After Aggressive Surgery for Pediatric Neocortical Epilepsy

2008 ◽  
Vol 1 (4) ◽  
pp. A351-A351 ◽  
Author(s):  
Michael Handler ◽  
Pramote Laoprasert
Keyword(s):  
Neocortical Epilepsy

Subdural Pharmacotherapy for the Treatment of Intractable Focal Neocortical Epilepsy

2012 ◽  
Vol 2 (1) ◽  
pp. 70-81 ◽  
Author(s):  
Nandor Ludvig
Keyword(s):  
Neocortical Epilepsy

scholarly journals Locally Applied Valproate Enhances Survival in Rats after Neocortical Treatment with Tetanus Toxin and Cobalt Chloride

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Dirk-Matthias Altenmüller ◽  
Jonas M. Hebel ◽  
Michael P. Rassner ◽  
Silvanie Volz ◽  
Thomas M. Freiman ◽  
...  
Keyword(s):  
Tetanus Toxin ◽  
Cobalt Chloride ◽  
Local Application ◽  
Controlled Study ◽  
Epileptic Focus ◽  
Depth Electrodes ◽  
Spontaneous Seizures ◽  
Neocortical Epilepsy ◽  
The Right ◽  
Therapy Strategies

Purpose. In neocortical epilepsies not satisfactorily responsive to systemic antiepileptic drug therapy, local application of antiepileptic agents onto the epileptic focus may enhance treatment efficacy and tolerability. We describe the effects of focally applied valproate (VPA) in a newly emerging rat model of neocortical epilepsy induced by tetanus toxin (TeT) plus cobalt chloride (CoCl2).Methods. In rats, VPA (n=5) or sodium chloride (NaCl) (n=5) containing polycaprolactone (PCL) implants were applied onto the right motor cortex treated before with a triple injection of 75 ng TeT plus 15 mg CoCl2. Video-EEG monitoring was performed with intracortical depth electrodes.Results. All rats randomized to the NaCl group died within one week after surgery. In contrast, the rats treated with local VPA survived significantly longer (P<0.01). In both groups, witnessed deaths occurred in the context of seizures. At least3/4of the rats surviving the first postoperative day developed neocortical epilepsy with recurrent spontaneous seizures.Conclusions. The novel TeT/CoCl2approach targets at a new model of neocortical epilepsy in rats and allows the investigation of local epilepsy therapy strategies. In this vehicle-controlled study, local application of VPA significantly enhanced survival in rats, possibly by focal antiepileptic or antiepileptogenic mechanisms.

Resting state connectivity in neocortical epilepsy: The epilepsy network as a patient-specific biomarker

2019 ◽  
Vol 130 (2) ◽  
pp. 280-288 ◽  
Author(s):  
Alexandria C. Marino ◽  
Genevieve J. Yang ◽  
Evgeniya Tyrtova ◽  
Kun Wu ◽  
Hitten P. Zaveri ◽  
...  
Keyword(s):  
Resting State ◽  
Patient Specific ◽  
Neocortical Epilepsy ◽  
Resting State Connectivity

Magnetic source imaging (MSI) in children with neocortical epilepsy: Surgical outcome association with 3D post-resection analysis

2013 ◽  
Vol 106 (1-2) ◽  
pp. 164-172 ◽  
Author(s):  
Hyunmi Kim ◽  
Pongkiat Kankirawatana ◽  
Jeff Killen ◽  
Allan Harrison ◽  
Ahyuda Oh ◽  
...  
Keyword(s):  
Surgical Outcome ◽  
Source Imaging ◽  
Magnetic Source Imaging ◽  
Magnetic Source ◽  
Neocortical Epilepsy

In Vivo Intrinsic Optical Signal Imaging of Neocortical Epilepsy

2007 ◽  
pp. 149-175
Author(s):  
Sonya Bahar ◽  
Minah Suh ◽  
Ashesh Mehta ◽  
Theodore H. Schwartz
Keyword(s):  
Optical Signal ◽  
Intrinsic Optical Signal ◽  
Neocortical Epilepsy

Optical Imaging of Human Neocortical Epilepsy

2005 ◽  
pp. 779-786
Author(s):  
Michael Haglund ◽  
Daryl Hochman
Keyword(s):  
Optical Imaging ◽  
Neocortical Epilepsy

scholarly journals Surgical Approaches in Nonlesional Neocortical Epilepsy

2011 ◽  
Vol 1 (2) ◽  
pp. 47-51 ◽  
Author(s):  
Sang Kun Lee
Keyword(s):  
Surgical Approaches ◽  
Neocortical Epilepsy

scholarly journals Tailored Cortical Resection for Neocortical Epilepsy : Preoperative Evaluation, Indication and Outcomes

2002 ◽  
Vol 11 (9) ◽  
pp. 584-591
Author(s):  
Shigeki Kameyama ◽  
Nobuhito Morota ◽  
Masafumi Fukuda ◽  
Makoto Oishi ◽  
Hiroshi Masuda
Keyword(s):  
Preoperative Evaluation ◽  
Neocortical Epilepsy
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