scholarly journals Treatment Outcomes in Patients Treated With Galcanezumab vs Placebo: Post Hoc Analyses From a Phase 3 Randomized Study in Patients With Episodic Cluster Headache

2020 ◽  
Vol 60 (10) ◽  
pp. 2254-2264
Author(s):  
David Kudrow ◽  
J. Scott Andrews ◽  
Mallikarjuna Rettiganti ◽  
Tina Oakes ◽  
Jennifer Bardos ◽  
...  
Keyword(s):  
Cluster Headache ◽  
Treatment Outcomes ◽  
Randomized Study ◽  
Phase 3 ◽  
Episodic Cluster Headache ◽  
Post Hoc

scholarly journals Impact of Galcanezumab on Total Pain Burden: A Post Hoc Analysis of a Phase 3, Randomized, Double-Blind, Placebo-Controlled Study in Patients with Episodic Cluster Headache

2021 ◽  
Vol Volume 14 ◽  
pp. 2059-2070
Author(s):  
J Scott Andrews ◽  
David Kudrow ◽  
Mallikarjuna Rettiganti ◽  
Tina Oakes ◽  
Jennifer N Bardos ◽  
...  
Keyword(s):  
Cluster Headache ◽  
Controlled Study ◽  
Phase 3 ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Post Hoc Analysis ◽  
Total Pain ◽  
Episodic Cluster Headache ◽  
Post Hoc

scholarly journals Efficacy of duloxetine for multisite pain in patients with knee pain due to osteoarthritis: An exploratory post hoc analysis of a Japanese phase 3 randomized study

2020 ◽  
Author(s):  
Naohiro Itoh ◽  
Toshinaga Tsuji ◽  
Mitsuhiro Ishida ◽  
Toshimitsu Ochiai ◽  
Shinichi Konno ◽  
...  
Keyword(s):  
Knee Pain ◽  
Randomized Study ◽  
Phase 3 ◽  
Post Hoc Analysis ◽  
Multisite Pain ◽  
Post Hoc

scholarly journals Efficacy of duloxetine for multi-site pain in patients with knee pain due to osteoarthritis: an exploratory post hoc analysis of a Japanese phase 3 randomized study

2019 ◽  
Vol 27 ◽  
pp. S499-S500
Author(s):  
N. Itoh ◽  
T. Tsuji ◽  
M. Ishida ◽  
T. Ochiai ◽  
S. Konno ◽  
...  
Keyword(s):  
Knee Pain ◽  
Randomized Study ◽  
Phase 3 ◽  
Post Hoc Analysis ◽  
Post Hoc ◽  
Site Pain

Fr175 TREATMENT OUTCOMES IN PATIENTS WITH EOSINOPHILIC ESOPHAGITIS WITH OR WITHOUT CONCOMITANT THERAPIES: POST HOC ANALYSIS FROM A PHASE 3 TRIAL OF BUDESONIDE ORAL SUSPENSION

2021 ◽  
Vol 160 (6) ◽  
pp. S-250
Author(s):  
Ikuo Hirano ◽  
David A. Katzka ◽  
Margaret H. Collins ◽  
Abigail M. Wojtowicz ◽  
Wenwen Zhang ◽  
...  
Keyword(s):  
Treatment Outcomes ◽  
Eosinophilic Esophagitis ◽  
Oral Suspension ◽  
Phase 3 ◽  
Post Hoc Analysis ◽  
Post Hoc

Randomised trial on episodic cluster headache with an angiotensin II receptor blocker

Cephalalgia ◽  
2013 ◽  
Vol 33 (12) ◽  
pp. 1026-1034 ◽  
Author(s):  
Erling Tronvik ◽  
Troels Wienecke ◽  
Inge Monstad ◽  
Carl Dahløf ◽  
Magne Geir Bøe ◽  
...  
Keyword(s):  
Placebo Group ◽  
Angiotensin Ii ◽  
Cluster Headache ◽  
Randomised Trial ◽  
Angiotensin Ii Receptor Blocker ◽  
Angiotensin Ii Receptor ◽  
Double Blind ◽  
Temporal Properties ◽  
Episodic Cluster Headache ◽  
Post Hoc

Objectives The aim of this study was to evaluate the angiotensin II receptor antagonist candesartan as prophylactic medication in patients with episodic cluster headache. Methods This study comprised a prospective, placebo-controlled, double-blind, parallel-designed trial performed in seven centres in Scandinavia. Forty (40) patients with episodic cluster headache (ICHD-2) were recruited and randomised over a five-year period to placebo or 16 mg candesartan in the first week, and placebo or 32 mg candesartan in the second and third week. Results The number of cluster headache attacks (primary efficacy variable) during the three-week treatment period was reduced from 14.3 ± 9.2 attacks in week 1 to 5.6 ± 7.0 attacks in week 3 (−61%) in the candesartan group and from 16.8 ± 14.1 attacks in week 1 to 10.5 ± 11.3 attacks in week 3 (−38%) in the placebo group. The difference between the candesartan and placebo group was not significant with the pre-planned non-parametric ranking test, but a post-hoc exact Poisson test, which takes into account the temporal properties of the data, revealed a significant result ( p < 0.0001). Conclusions This was a negative trial. Post-hoc statistics suitable to describe the temporal changes in cluster headache indicate that conduction of future larger studies may be justified.

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