Fulminant metastatic calcinosis with cutaneous necrosis in a child with end-stage renal disease and tertiary hyperparathyroidism

1996 ◽  
Vol 135 (4) ◽  
pp. 617-622 ◽  
Author(s):  
Ch.C. ZOUBOULIS ◽  
U. BLUME-PEYTAVI ◽  
Th. LENNERT ◽  
P.G. STAVROPOULOS ◽  
A. SCHWARZ ◽  
...  
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Tertiary Hyperparathyroidism ◽  
Cutaneous Necrosis ◽  
Stage Renal Disease ◽  
End Stage

Fulminant metastatic calcinosis with cutaneous necrosis in a child with end-stage renal disease and tertiary hyperparathyroidism

1996 ◽  
Vol 135 (4) ◽  
pp. 617-622 ◽  
Author(s):  
Ch.C. ZOUBOULIS ◽  
U. BLUME-PEYTAVI ◽  
Th. LENNERT ◽  
P.G. STAVROPOULOS ◽  
A. SCHWARZ ◽  
...  
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Tertiary Hyperparathyroidism ◽  
Cutaneous Necrosis ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals Secondary and Tertiary Hyperparathyroidism: A Narrative Review

2019 ◽  
Vol 109 (4) ◽  
pp. 271-278 ◽  
Author(s):  
W. Y. van der Plas ◽  
M. E. Noltes ◽  
T. M. van Ginhoven ◽  
S. Kruijff
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Treatment Options ◽  
Phosphate Binders ◽  
Tertiary Hyperparathyroidism ◽  
Increased Risk ◽  
Vitamin D Supplements ◽  
The Individual ◽  
Stage Renal Disease ◽  
End Stage

End-stage renal disease is often complicated by the occurrence of secondary and eventually tertiary hyperparathyroidism, characterized by increased parathormone, calcium, and phosphate concentrations. Related symptoms include pruritus and osteodynia, concentration difficulties, and feelings of depression may be present. In the long-term, end-stage renal disease patients with hyperparathyroidism have an increased risk of all-cause and cardiovascular mortality. Among treatment options are vitamin D supplements, phosphate binders, calcimimetics, and surgical parathyroidectomy. Determining the optimal treatment for the individual patient is challenging for nephrologists and endocrine surgeons. This review resumes the pathogenesis of hyperparathyroidism, clinical presentation, required diagnostic work-up, and discusses indications for the available treatment options for patients with secondary and tertiary hyperparathyroidism.

scholarly journals Progressive valvular calcifications with critical aortic stenosis in a 25-year-old woman with end-stage renal disease on haemodialysis: a case report

2021 ◽  
Vol 5 (7) ◽  
Author(s):  
Christina Stolzenburg Oxlund ◽  
Helle Hansen ◽  
Stinus Hansen ◽  
Allan Rohold
Keyword(s):  
Aortic Stenosis ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Phosphate Metabolism ◽  
Transthoracic Echocardiogram ◽  
Tertiary Hyperparathyroidism ◽  
Critical Aortic Stenosis ◽  
Stage Renal Disease ◽  
End Stage ◽  
Calcium And Phosphate Metabolism

Abstract Background  The increased risk of cardiovascular morbidity and mortality in chronic kidney disease (CKD) and end-stage renal disease (ESRD) seems particularly pronounced in patients with concomitant aortic and mitral valvular calcifications. Valvular calcification (VC) is accelerated in patients with CKD and even more so with ESRD and haemodialysis (HD) due to premature endothelial cell dysfunction. Mineral and bone disorder (CKD-MBD) is a common complication of CKD/ESRD and may play a pivotal role in VC. Case summary  A 25-year-old woman with congenital hypoplastic kidneys and ESRD on HD from the age of 19 was admitted to the emergency department suffering from chest pain and dyspnoea. Transthoracic echocardiogram (TTE) revealed critical aortic stenosis (AS) with indexed aortic valve area 0.4 cm2/m2, a mean gradient 58 mmHg and a moderate mitral stenosis with a mean gradient 6–8 mmHg developed over the course of 2 years, as a normal TTE was performed at that time. During HD, the patient had longstanding alterations in calcium and phosphate metabolism including secondary hyperparathyroidism that eventually progressed into tertiary hyperparathyroidism. Efforts were made to treat CKD-MBD but patient compliance was low. Subtotal parathyroidectomy was performed 6 months prior to admission. The patient had dual mechanical valve replacement. Discussion  Valvular calcification is common in patients with CKD/ESRD and in particular in patients on HD. Rapid progression of valve disease in this case may be related to the combination of low patient adherence and sustained disturbed calcium and phosphate metabolism with tertiary hyperparathyroidism. Transthoracic echocardiogram should be performed in patients on HD even with minor suspicion of VC and in patients with low adherence and disturbance of calcium and phosphate metabolism.

scholarly journals Brown Tumor as a Result of Hyperparathyroidism in an End-Stage Renal Disease Patient

2011 ◽  
Vol 2011 ◽  
pp. 1-3 ◽  
Author(s):  
Jesse M. Jakubowski ◽  
Ines Velez ◽  
Shawn A. McClure
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Disease Patient ◽  
Brown Tumor ◽  
Histologic Diagnosis ◽  
Tertiary Hyperparathyroidism ◽  
History Of ◽  
The Right ◽  
Stage Renal Disease ◽  
End Stage

A 49-year-old male with known history of end-stage renal disease (ESRD) presents with an intraoral exophytic mass of the right mandible. This lesion was given a histologic diagnosis of a Brown tumor.Purpose. To allow physicians to include this lesion in a differential diagnosis when evaluating patients with primary, secondary, or tertiary hyperparathyroidism.

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