Changes in plasma renin activity and haemodynamics during vasodilator therapy in conscious dogs with myocardial infarction or chronic volume overload

1983 ◽  
Vol 13 (4) ◽  
pp. 331-338 ◽  
Author(s):  
H. POULEUR ◽  
R. L. ENGLER ◽  
J. LINK ◽  
M. P. PRINTZ ◽  
J. W. COVELL
2019 ◽  
Vol 83 (6) ◽  
pp. 1324-1329 ◽  
Author(s):  
Daisuke Kamon ◽  
Hiroyuki Okura ◽  
Akihiko Okamura ◽  
Yasuki Nakada ◽  
Yukihiro Hashimoto ◽  
...  

1973 ◽  
Vol 19 (12) ◽  
pp. 1396-1399 ◽  
Author(s):  
Samuel D Goldberg ◽  
F W Spierto

Abstract Twenty to thirty percent of patients with essential hypertension have subnormal plasma renin activity (PRA) and lower incidences of stroke and myocardial infarction. NaCl intake influences PRA, which should thus be compared with 24-h urinary sodium excretion. Because such specimens are difficult to collect accurately, we investigated the relation between PRA and sodium in casual (i.e., untimed) urine specimens and found none. However, PRA and urinary Na/creatinine ratio are inversely correlated for casual specimens. This method is useful for screening individuals whose salt intake is low. Mean PRA, measured by the Schwarz-Mann procedure, was 0.62 ± 0.12 (SD) ng/ml per hour for 59 normotensive volunteers, 35% lower by the Squibb procedure.


1983 ◽  
Vol 245 (1) ◽  
pp. F119-F122 ◽  
Author(s):  
E. R. Farhi ◽  
J. R. Cant ◽  
A. C. Barger

We investigated the relationship between renal arterial pressure (RAP) and systemic plasma renin activity (PRA) in five uninephrectomized conscious dogs on normal salt (80 meq Na+/day) and low salt (10 meq Na+/day) diets. The RAP was controlled by an inflatable cuff placed around the origin of the renal artery. In both salt states the PRA was an exponential function of the RAP: log (PRA) = (-0.026 X RAP) + 2 on the normal salt diet (r = 0.96) and log (PRA) = (-0.026 X RAP) + 2.5 on the low salt diet (r = 0.99). At any RAP, the value of the low salt PRA was 3 times that of the normal salt PRA. Accordingly, a reduction in salt intake increases the sensitivity of the renal baroreceptor so that the absolute value of PRA increases at any RAP, but the percentage change in PRA caused by any change in RAP is the same in both normal and low salt states.


2004 ◽  
Vol 100 (2) ◽  
pp. 139-146 ◽  
Author(s):  
R. H. Naseem ◽  
W. Hedegard ◽  
T. D. Henry ◽  
J. Lessard ◽  
K. Sutter ◽  
...  

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