Cholesterol saturation rather than phospholipid/bile salt ratio or protein content affects crystallization sequences in human gallbladder bile

2004 ◽  
Vol 34 (10) ◽  
pp. 656-663 ◽  
Author(s):  
N. G. Venneman ◽  
P. Portincasa ◽  
G. P. vanBerge-Henegouwen ◽  
K. J. van Erpecum
Keyword(s):  
Bile Salt ◽  
Protein Content ◽  
Gallbladder Bile ◽  
Human Gallbladder ◽  
Cholesterol Saturation

Bile salt hydrophobicity and phosphatidylcholine acyl chain composition in vesicles and mixed micelles from model and human gallbladder bile

1995 ◽  
Vol 108 (4) ◽  
pp. A1154
Author(s):  
W. Renooij ◽  
K.J. van Erpecum ◽  
B.J.M. van de Heijning ◽  
P. Portincasa ◽  
G.P. vanBerge-Henegouwen
Keyword(s):  
Bile Salt ◽  
Mixed Micelles ◽  
Acyl Chain ◽  
Gallbladder Bile ◽  
Human Gallbladder ◽  
Chain Composition ◽  
Acyl Chain Composition

scholarly journals Stability of Human Gallbladder Bile: Effect of Freezing

2001 ◽  
Vol 15 (6) ◽  
pp. 363-366 ◽  
Author(s):  
Paul Janowitz ◽  
Richard Mason ◽  
Wolfgang Kratzer
Keyword(s):  
Saturation Index ◽  
Gallbladder Bile ◽  
Needle Puncture ◽  
Nucleation Time ◽  
Human Gallbladder ◽  
Fine Needle ◽  
Cholesterol Saturation ◽  
Before And After ◽  
Cholesterol Saturation Index ◽  
Fine Needle Puncture

In the present study, the stability of the most essential biliary parameters of human gallbladder bile at -18°C was examined over several months. In 12 patients with gallstone disease (10 female, two male; 52.1±13.3 years of age), bile was obtained through fine needle puncture of the gallbladder under local anesthetic. The concentrations of total lipids, cholesterol, phospholipids and bile acids, and the cholesterol saturation index and crystal appearance time were determined before and after freezing over a mean period of 4.38±2.9 months. Gallbladder bile obtained by fine needle puncture has proved to be of excellent quality. The total lipid concentration was unchanged before (8.30±4.16 g/dL) and after freezing (9.16±4.54 g/dL, P=0.6027). The biliary cholesterol, phospholipids and bile acid concentrations, and cholesterol saturation index showed no statistically significant differences before and after freezing. A significant difference arises in the context of subdivision of the group to the nucleation time. Before freezing, most patients had a nucleation time between five and eight days, which shortened to between one and four days after thawing (P=0.0100). The authors conclude that, with the exception of the nucleation time, human gallbladder bile can be stored at -18°C for four months with stability of major lipid components.

Cholesterol saturation, not proteins or cholecystitis, is critical for crystal formation in human gallbladder bile☆☆☆

1998 ◽  
Vol 114 (5) ◽  
pp. 1016-1023 ◽  
Author(s):  
Juan Francisco Miquel ◽  
Liliana Núñez ◽  
Ludwig Amigo ◽  
Sergio González ◽  
Alejandro Raddatz ◽  
...  
Keyword(s):  
Gallbladder Bile ◽  
Crystal Formation ◽  
Human Gallbladder ◽  
Cholesterol Saturation

Molecular composition of biliary phosphatidylcholines, as related to cholesterol saturation, transport and nucleation in human gallbladder bile

1992 ◽  
Vol 15 (1-2) ◽  
pp. 59-66 ◽  
Author(s):  
Mario Angelico ◽  
Stefano Ginanni Corradini ◽  
Roberta Masella ◽  
Domenico Alvaro ◽  
Alfredo Cantafora ◽  
...  
Keyword(s):  
Gallbladder Bile ◽  
Molecular Composition ◽  
Human Gallbladder ◽  
Cholesterol Saturation

scholarly journals Effects of bile salt and phospholipid hydrophobicity on lithogenicity of human gallbladder bile

1994 ◽  
Vol 24 (11) ◽  
pp. 744-750 ◽  
Author(s):  
K. J. VAN ERPECUM ◽  
P. PORTINCASA ◽  
M. F. J. STOLK ◽  
B. J. M. VAN DE HEIJNING ◽  
E. S. VAN DER ZAAG ◽  
...  
Keyword(s):  
Bile Salt ◽  
Gallbladder Bile ◽  
Human Gallbladder

scholarly journals The Effect of Biliary Bile Acid Concentration and Composition on the Calcium Level in Human Gallbladder Bile.

1993 ◽  
Vol 171 (4) ◽  
pp. 297-307 ◽  
Author(s):  
NAOKI TAMASAWA ◽  
MASASHI YONEDA ◽  
ISAO MAKINO ◽  
KAZUO TAKEBE ◽  
KEN SONE ◽  
...  
Keyword(s):  
Bile Acid ◽  
Acid Concentration ◽  
Calcium Level ◽  
Gallbladder Bile ◽  
Human Gallbladder ◽  
Bile Acid Concentration ◽  
Biliary Bile Acid
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