Sistema Internacional Yokohama para el informe de la citología mamaria. Academia Internacional de Citología

Fine needle aspiration biopsy cytology is part of the diagnostic triad in the evaluation of breast pathology, along with clinical and mammography or ultrasound findings. The Yokohama international system of the International Agency for Cytology has been proposed to report fine needle puncture-aspiration biopsy breast cytology, through 5 diagnostic categories: Inadequate/insufficient, benign, atypical, suspicious for malignancy and malignant, including in each of these definitions, key cytological diagnostic criteria and suggestions for clinical management. The objective of this article was to know the guidelines of this new breast cytological classification system for its implementation in this region. Fine needle puncture-aspiration biopsy is a precise and effective method to diagnose different breast lesions, which requires an adequate cell sample and a precise cytomorphological interpretation. The application of standardized Yokohama system will allow to improve the evaluation, diagnosis and clinical management of the breast pathology. Keywords: Breast cytology. Fine-needle aspiration biopsy (FNAB). Reporting system Yokohama.

Proteomics and Organoid Culture Reveal the Underlying Pathogenesis of Hashimoto’s Thyroiditis

Hashimoto’s thyroiditis (HT) is an autoimmune disease, and its incidence continues to rise. Although scientists have studied this disease for many years and discovered the potential effects of various proteins in it, the specific pathogenesis is still not fully comprehended. To understand HT and translate this knowledge to clinical applications, we took the mass spectrometric analysis on thyroid tissue fine-needle puncture from HT patients and healthy people in an attempt to make a further understanding of the pathogenesis of HT. A total of 44 proteins with differential expression were identified in HT patients, and these proteins play vital roles in cell adhesion, cell metabolism, and thyroxine synthesis. Combining patient clinical trial sample information, we further compared the transient changes of gene expression regulation in HT and papillary thyroid carcinoma (PTC) samples. More importantly, we developed patient-derived HT and PTC organoids as a promising new preclinical model to verify these potential markers. Our data revealed a marked characteristic of HT organoid in upregulating chemokines that include C-C motif chemokine ligand (CCL) 2 and CCL3, which play a key role in the pathogenesis of HT. Overall, our research has enriched everyone’s understanding of the pathogenesis of HT and provides a certain reference for the treatment of the disease.

Management Strategy of Local Subcutaneous Effusion After Auricle Reconstruction

Objectives: Microtia is a severe congenital malformation of the external ear, and auricular reconstruction is still a challenge for plastic surgeons because of the complicated procedures and rare conditions. This study aimed to describe the location of subcutaneous effusion after auricular reconstruction and explore the clinical efficacy of the indwelling needle puncture drainage method in the treatment of local subcutaneous effusion. Methods: From January 2017 to December 2019, 1240 patients (1296 affected sides) who underwent auricular reconstruction using autogenous cartilage framework in the Plastic Surgery Hospital of Chinese Academy of Medical Science and Peking Union Medical College were selected. The local subcutaneous effusion occurred within 5 days after the drainage tube was removed, and the indwelling needle was used for puncture and drainage in the postoperative treatment. Results: A total of 55 patients had subcutaneous effusion after the operation, including 24 cases with Nagata’s method and 31 cases with the expanded single-flap method. One patient showed no obvious reduction after puncture and drainage by indwelling needle and improved after the secondary operation. Two patients had slight cartilage absorption. The remaining patients had good results. Conclusions: The method of the indwelling needle for puncture and drainage is easy to operate. The problem of local subcutaneous effusion after auricular reconstruction can be solved and good efficacy can be obtained.

Retraction: Research on Force Analysis and Path Planning of Flexible Needle Puncture Bending Modelling (J. Phys.: Conf. Ser. 1952 042058)

This article has been retracted by the authors following an admission that this article uses work from [1] without attribution. IOP Publishing has investigated in line with the COPE guidelines, and agree the article should be retracted. The authors agree to this retraction and apologise to the original creator of the work. 1. Shi Kaiming 2019 Research on Movement Modeling and Path Planning of Flexible Cannula Needle Based on Finite Deformation Theory PhD Thesis Harbin University of Science and Technology, China (https://t.cnki.net/kcms/detail?v=zDWWPGpj7XNIYVmjPzotLQQrqE5suL8UT58pa0eYSzNWTc6cTneXhheuT3eZOa2hfsihnencE2errhffb1l--WQrpYCErNwN730qt90Gb_CdjKxkPFYC1Ppuj1cZoBQyYGNMZRph70O-WGDNoSWGdk1rtHYrxJSM&uniplatform=%20NZKPT) Retraction published: 03 December 2021

Electronics with shape actuation for minimally invasive spinal cord stimulation

Spinal cord stimulation is one of the oldest and most established neuromodulation therapies. However, today, clinicians need to choose between bulky paddle-type devices, requiring invasive surgery under general anesthetic, and percutaneous lead–type devices, which can be implanted via simple needle puncture under local anesthetic but offer clinical drawbacks when compared with paddle devices. By applying photo- and soft lithography fabrication, we have developed a device that features thin, flexible electronics and integrated fluidic channels. This device can be rolled up into the shape of a standard percutaneous needle then implanted on the site of interest before being expanded in situ, unfurling into its paddle-type conformation. The device and implantation procedure have been validated in vitro and on human cadaver models. This device paves the way for shape-changing bioelectronic devices that offer a large footprint for sensing or stimulation but are implanted in patients percutaneously in a minimally invasive fashion.

Management and treatment procedure of windpuff caused by lice infestation in domestic pigeon: A case report

A rare case of windpuff was diagnosed in 7 months old two domestic pigeons due to itching and scratching with inanimate objects caused by lice infestation reported in Begumganj upazila hospital, Noakhali district, Bangladesh. This is the first case of domestic pigeon recorded in Bangladesh and the aim of this case study is to determine the causal agent, treatment and management procedure of windpuff. Parasitological examination of feathers revealed the presence of Columbicola columbae, a dorso-ventrally flattened biting type louse. Using needle puncture was able to release the ballooning condition and the pigeons were treated with antimicrobial drug (Enrofloxacin @10mg/kg body weight) through drinking water along with multivitamin and ectoparasiticidal drug (Ivermectin @0.4mg/kg body weight). Both the pigeon was successfully recovered without any further complications within four days.

Marked differences in local bone remodelling in response to different marrow stimulation techniques in a large animal

Marrow stimulation, including subchondral drilling and microfracture, is the most commonly performed cartilage repair strategy, whereby the subchondral bone plate is perforated to release marrow-derived cells into a cartilage defect to initiate repair. Novel scaffolds and therapeutics are being designed to enhance and extend the positive short-term outcomes of this marrow stimulation. However, the translation of these newer treatments is hindered by bony abnormalities, including bone resorption, intralesional osteophytes, and bone cysts, that can arise after marrow stimulation. In this study, three different marrow stimulation approaches – microfracture, subchondral drilling and needle-puncture – were evaluated in a translationally relevant large-animal model, the Yucatan minipig. The objective of the study was to determine which method of marrow access (malleted awl, drilled Kirschner wire or spring-loaded needle) best preserved the underlying subchondral bone. Fluorochrome labels were injected at the time of surgery and 2 weeks post-surgery to capture bone remodelling over the first 4 weeks. Comprehensive outcome measures included cartilage indentation testing, histological grading, microcomputed tomography and fluorochrome imaging. Findings indicated that needle-puncture devices best preserved the underlying subchondral bone relative to other marrow access approaches. This may relate to the degree of bony compaction occurring with marrow access, as the Kirschner wire approach, which consolidated bone the most, induced the most significant bone damage with marrow stimulation. This study provided basic scientific evidence in support of updated marrow stimulation techniques for preclinical and clinical practice.

Revascularization of Chronic Iliac Vein Occlusion Using Balloon-Assisted Transseptal Needle Puncture Technique

Objectives To evaluate the utility of a transseptal needle for balloon-assisted sharp recanalization of chronically occluded central venous structures. Background Chronically occluded central veins are not an uncommon problem, which may arise due to a plethora of reasons. Traditionally, wire and catheter techniques are often used first in an attempt to reestablish flow. When these methods fail, more aggressive techniques are employed, such as sharp recanalization using the back end of wires, Teflon-coated wires, or Rosch–Uchida or Colapinto needles. However, utilization of transseptal needles, traditionally reserved for cardiac procedures, has rarely been described. Methods Transseptal needle was utilized for balloon-assisted sharp recanalization after traditional wire and catheter techniques failed in revascularization of chronically occluded iliac veins. Results Transseptal needle was utilized successfully in two cases in revascularization of chronically occluded central veins. Conclusion Transseptal needle is a viable tool to add to the interventional radiologists’ armamentarium in reestablishing flow in chronically occluded central veins.