The role of free oxygen radicals and sperm function

The role of free oxygen radicals in experimental acute pancreatitis induced by common bile duct ligation was investigated by measuring malondialdehyde levels in the rat pancreas. Also, the potential role of leucocytes as the source of free oxygen radicals was tested by inducing leukopenia with methotrexate. The malondialdehyde levels in the control, pancreatitis and pancreatitis + methotrexate groups were 9.6 ± 2.0, 44.8 ± 11.4, and 25.6 ± 5.0 nmol malondialdehyde/ g pancreas tissue respectively. The corresponding histopathological severity scores were 0.5 ± 0.7, 8.1 ± 1.2 and 3.7 ± 1.1. The results suggest that the leucocyte may be an important source of free oxygen radicals in this experimental model.

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Role of free oxygen radicals in bronchial asthma and in cystic fibrosis

Respiratory Medicine ◽

10.1016/s0954-6111(05)80247-1 ◽

1994 ◽

Vol 88 (10) ◽

pp. 823

Author(s):

Z. Novák ◽

I. Németh ◽

I. Varga ◽

B. Matkovics ◽

K. Gyurkovits

Keyword(s):

Cystic Fibrosis ◽

Bronchial Asthma ◽

Oxygen Radicals ◽

Free Oxygen Radicals ◽

Free Oxygen

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THE ROLE OF FREE OXYGEN RADICALS IN THE ACTIVATION OF THE NK CYTOLYTIC PATHWAY

NK Cells and Other Natural Effector Cells ◽

10.1016/b978-0-12-341360-4.50150-5 ◽

1982 ◽

pp. 1011-1020 ◽

Cited By ~ 1

Author(s):

Stephen L. Helfand ◽

Jerome Werkmeister ◽

John C. Roder

Keyword(s):

Oxygen Radicals ◽

Free Oxygen Radicals ◽

Free Oxygen

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The role of free oxygen radicals in noise induced hearing loss: effects of melatonin and methylprednisolone

Auris Nasus Larynx ◽

10.1016/s0385-8146(01)00137-7 ◽

2002 ◽

Vol 29 (2) ◽

pp. 147-152 ◽

Cited By ~ 19

Author(s):

Turgut Karlidağ ◽

Şinasi Yalçin ◽

Ahmet Öztürk ◽

Bilal Üstündağ ◽

Üzeyir Gök ◽

...

Keyword(s):

Hearing Loss ◽

Oxygen Radicals ◽

Free Oxygen Radicals ◽

Noise Induced Hearing Loss ◽

Free Oxygen

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Role of free oxygen radicals in noise-related hearing impairment

Hearing Research ◽

10.1016/s0378-5955(01)00365-3 ◽

2001 ◽

Vol 162 (1-2) ◽

pp. 43-47 ◽

Cited By ~ 37

Author(s):

İrfan Kaygusuz ◽

Ahmet Öztürk ◽

Bilal Üstündağ ◽

Şinasi Yalçin

Keyword(s):

Hearing Impairment ◽

Oxygen Radicals ◽

Free Oxygen Radicals ◽

Free Oxygen

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Red Blood Cell Function and β2 Microglobulin Kinetics during Cuprophan Hemodialysis: A Hypothesis

The International Journal of Artificial Organs ◽

10.1177/039139888901201007 ◽

1989 ◽

Vol 12 (10) ◽

pp. 638-641 ◽

Cited By ~ 3

Author(s):

R.L Lins ◽

P. Zachée ◽

R. Daelemans ◽

E. Vanden Broecke ◽

M.A. Boogaerts ◽

...

Keyword(s):

Oxygen Radicals ◽

Cell Function ◽

Chronic Hemodialysis ◽

Free Oxygen Radicals ◽

Exact Role ◽

Free Oxygen ◽

Pathogenetic Factor ◽

Clinically Significant ◽

Local Release

The exact role of β2microglobulin (β2m) in dialysis amyloidosis is yet not known. Local release of β2m from the endothelial cells of the lung and other tissues as a consequence of acute-phase activation due to the contact of blood with membranes has still to be considered a possible pathogenetic factor in this syndrome. β2m kinetics and decrease of glutathione content in RBC were studied in 41 chronic hemodialysis patients during cuprophan dialysis. The latter test reflects the RBC scavenger function for free oxygen radicals. Only 30% of patients showed a clinically significant increase in β2m. The change in β2m in this group between the start and 180 minutes, corrected for plasma volume, was 23.1±3.6% and the change in gluthathione content between the start and 15 minutes was 4.5±3.4%. In these patients there was a significant correlation between β2m production and decrease of gluthathione (R= -0.61, p= 0.0299). It is possible that the production of free oxygen radicals during bioincompatible dialysis leads to cellular toxicity with release ofβ2m which may be prevented to some extent by the scavenger role of RBC.

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