Novel applications of external anal sphincter muscle sarcomere length to enhance the anal canal function

2010 ◽  
Vol 23 (1) ◽  
pp. 70-e7 ◽  
Author(s):  
M. R. Rajasekaran ◽  
Y. Jiang ◽  
V. Bhargava ◽  
R. L. Lieber ◽  
R. K. Mittal
Keyword(s):  
Anal Canal ◽  
Anal Sphincter ◽  
External Anal Sphincter ◽  
Sarcomere Length ◽  
Sphincter Muscle ◽  
Anal Sphincter Muscle ◽  
Novel Applications ◽  
External Anal Sphincter Muscle

T1341 Sustained Improvement in Anal Canal Function Following External Anal Sphincter Muscle Plication

2010 ◽  
Vol 138 (5) ◽  
pp. S-541
Author(s):  
Mahadevan R. Rajasekaran ◽  
Yanfen Jiang ◽  
Amir Motamedi ◽  
Valmik Bhargava ◽  
Ravinder K. Mittal
Keyword(s):  
Anal Canal ◽  
Anal Sphincter ◽  
External Anal Sphincter ◽  
Sphincter Muscle ◽  
Sustained Improvement ◽  
Anal Sphincter Muscle ◽  
External Anal Sphincter Muscle

scholarly journals Stretch -Induced Force Regulation in External Anal Sphincter Muscle: Implications for the Anal Canal Function

2011 ◽  
Vol 140 (5) ◽  
pp. S-796
Author(s):  
Mahadevan R. Rajasekaran ◽  
Yanfen Jiang ◽  
Mitra Salehi ◽  
Valmik Bhargava ◽  
Ravinder K. Mittal
Keyword(s):  
Anal Canal ◽  
Anal Sphincter ◽  
External Anal Sphincter ◽  
Sphincter Muscle ◽  
Anal Sphincter Muscle ◽  
External Anal Sphincter Muscle

scholarly journals HISTOCHEMICAL STUDY ON THE EXTERNAL ANAL SPHINCTER MUSCLE OF THE RABBIT

1979 ◽  
Vol 12 (1) ◽  
pp. 56-62 ◽  
Author(s):  
SHIGEKI KUZUHARA ◽  
MASANORI TOMONAGA ◽  
YASUO TOYOKURA ◽  
TOSHIAKI TAKASU
Keyword(s):  
Anal Sphincter ◽  
External Anal Sphincter ◽  
Histochemical Study ◽  
Sphincter Muscle ◽  
Anal Sphincter Muscle ◽  
External Anal Sphincter Muscle

scholarly journals 465 Myoarchitectural and Functional Alteration in the External Anal Sphincter Muscle Following Experimental Surgical Myotomy

2013 ◽  
Vol 144 (5) ◽  
pp. S-83 ◽  
Author(s):  
Mahadevan R. Rajasekaran ◽  
YoungJIn Seo ◽  
Mitra Salehi ◽  
Valmik Bhargava ◽  
Shantanu Sinha ◽  
...  
Keyword(s):  
Anal Sphincter ◽  
External Anal Sphincter ◽  
Sphincter Muscle ◽  
Anal Sphincter Muscle ◽  
Functional Alteration ◽  
External Anal Sphincter Muscle

Myoarchitectural and functional alterations in rabbit external anal sphincter muscle following experimental surgical trauma

2014 ◽  
Vol 307 (4) ◽  
pp. G445-G451 ◽  
Author(s):  
M. Raj Rajasekaran ◽  
Shantanu Sinha ◽  
Youngjin Seo ◽  
Mitra Salehi ◽  
Valmik Bhargava ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Anal Sphincter ◽  
External Anal Sphincter ◽  
Sarcomere Length ◽  
Diffusion Tensor ◽  
Regenerative Process ◽  
Surgical Trauma ◽  
Sphincter Muscle ◽  
Partial Recovery ◽  
Anal Sphincter Muscle

Obstetrical trauma to external anal sphincter (EAS) is extremely common; however, its role in the development of anal incontinence is not clear. We examined the regenerative process and functional impact of experimental surgical trauma to EAS muscle in an animal model. Surgical myotomy, a craniocaudal incision extending along the entire length and thickness of the EAS, was performed in rabbits. Animals were allowed to recover, and anal pressures were recorded at weekly intervals for 12 wk using a custom-designed probe system to determine the length-tension property of EAS muscle. Animals were killed at predetermined time intervals, and the anal canal was harvested for histochemical studies (for determination of muscle/connective tissue/collagen) and sarcomere length measurement. In addition, magnetic resonance diffusion tensor imaging (MR-DTI) and fiber tracking was performed to determine myoarchitectural changes in the EAS. Myotomy of the EAS muscle resulted in significant impairment of its length-tension property that showed only partial recovery during the 12-wk study period. Histology revealed marked increase in the fibrosis (connective tissue = 69% following myotomy vs. 28% in controls) at 3 wk, which persisted at 12 wk. Immunostaining studies confirmed deposition of collagen in the fibrotic tissue. There was no change in the sarcomere length following myotomy. MR-DTI studies revealed disorganized muscle fiber orientation in the regenerating muscle. We conclude that, following experimental injury, the EAS muscle heals with an increase in the collagen content and loss of normal myoarchitecture, which we suspect is the cause of impaired EAS function.

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