Renal cadaveric transplantation in diabetics using total lymphoid irradiation or cyclosporin A: A controlled randomized study

1988 ◽  
Vol 1 (1) ◽  
pp. 64-68 ◽  
Author(s):  
M. Waer ◽  
Y. Vanrenterghem ◽  
L. Roels ◽  
R- Verberckmoes ◽  
D. Hauglustaine ◽  
...  
Keyword(s):  
Cyclosporin A ◽  
Randomized Study ◽  
Total Lymphoid Irradiation ◽  
Cadaveric Transplantation

Renal cadaveric transplantation in diabetics using total lymphoid irradiation or cyclosporin A

1988 ◽  
Vol 1 (2) ◽  
pp. 64-68 ◽  
Author(s):  
M. Waer ◽  
Y. Vanrenterghem ◽  
L. Roels ◽  
R. Verberckmoes ◽  
D. Hauglustaine ◽  
...  
Keyword(s):  
Cyclosporin A ◽  
Total Lymphoid Irradiation ◽  
Cadaveric Transplantation

A multicenter randomized study comparing cyclosporin-A alone and antithymocyte globulin with prednisone for treatment of severe aplastic anemia

1992 ◽  
Vol 5 ◽  
pp. 271-275 ◽  
Author(s):  
Eliane Gluckman ◽  
Hélène Esperou-Bourdeau ◽  
André Baruchel ◽  
Michel Boogaerts ◽  
Jean Briere ◽  
...  
Keyword(s):  
Cyclosporin A ◽  
Aplastic Anemia ◽  
Antithymocyte Globulin ◽  
Randomized Study ◽  
Severe Aplastic Anemia

Total lymphoid irradiation: Critical timing and combination with cyclosporin A for immunosuppression in a rat heart allograft model

1981 ◽  
Vol 30 (4) ◽  
pp. 365-371 ◽  
Author(s):  
John J. Rynasiewicz ◽  
David E.R. Sutherland ◽  
Katsuhiko Kawahara ◽  
John S. Najarian
Keyword(s):  
Cyclosporin A ◽  
Rat Heart ◽  
Total Lymphoid Irradiation ◽  
Heart Allograft ◽  
Critical Timing

TOTAL LYMPHOID IRRADIATION IN RENAL CADAVERIC TRANSPLANTATION IN DIABETICS

The Lancet ◽  
1985 ◽  
Vol 326 (8468) ◽  
pp. 1354 ◽  
Author(s):  
Mark Waer ◽  
Yves Vanrenterghem ◽  
Leo Roels ◽  
Roger Bouillon ◽  
Tony Lerut ◽  
...  
Keyword(s):  
Total Lymphoid Irradiation ◽  
Cadaveric Transplantation

Treatment of severe aplastic anemia with antithymocyte globulin and cyclosporin A with or without G-CSF in adults: a multicenter randomized study in Japan

Blood ◽  
2007 ◽  
Vol 110 (6) ◽  
pp. 1756-1761 ◽  
Author(s):  
Masanao Teramura ◽  
Akiro Kimura ◽  
Satsuki Iwase ◽  
Yuji Yonemura ◽  
Shinji Nakao ◽  
...  
Keyword(s):  
Cyclosporin A ◽  
Aplastic Anemia ◽  
Immunosuppressive Therapy ◽  
Antithymocyte Globulin ◽  
Randomized Study ◽  
Severe Aplastic Anemia ◽  
Febrile Episodes ◽  
To Receive

Abstract We report the results of a randomized study to elucidate whether addition of granulocyte colony-stimulating factor (G-CSF) to immunosuppressive therapy is valuable for the treatment of severe aplastic anemia (SAA) in adults. A total of 101 previously untreated patients (median age, 54 years; range, 19 to 75 years) were randomized to receive antithymocyte globulin (ATG) and cyclosporin A (CyA) (G-CSF− group) or ATG, CyA, and G-CSF (G-CSF+ group). In the G-CSF+ group, the hematologic response rate at 6 months was higher (77% vs 57%; P = .03) than in the G-CSF− group. No differences were observed between the groups in terms of the incidence of infections and febrile episodes. There were no differences between the G-CSF− group and the G-CSF+ group in terms of survival (88% vs 94% at 4 years), and the development of myelodysplastic syndrome (MDS)/acute leukemia (AL) (1 patient vs 2 patients). However, the relapse rate was lower in the G-CSF+ group compared with the G-CSF− group (42% vs 15% at 4 years; P = .01). Further follow-up is required to elucidate the role of G-CSF in immunosuppressive therapy for adult SAA.

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