Proceedings of the Symposium ‘Angiotensin AT1 Receptors: From Molecular Physiology to Therapeutics’: TRANSGENIC RATS: TOOLS TO STUDY THE FUNCTION OF THE RENIN-ANGIOTENSIN SYSTEM

1996 ◽  
Vol 23 (S3) ◽  
pp. 81-87 ◽  
Author(s):  
Michael Bader ◽  
Detlev Ganten
Keyword(s):  
Renin Angiotensin System ◽  
Transgenic Rats ◽  
Molecular Physiology ◽  
At1 Receptors ◽  
Angiotensin System ◽  
Renin Angiotensin

scholarly journals Cardiac remodeling during and after renin–angiotensin system stimulation in Cyp1a1-Ren2 transgenic rats

2013 ◽  
Vol 15 (1) ◽  
pp. 69-81 ◽  
Author(s):  
Bart FJ Heijnen ◽  
Leonie PJ Pelkmans ◽  
AH Jan Danser ◽  
Ingrid M Garrelds ◽  
John J Mullins ◽  
...  
Keyword(s):  
Cardiac Remodeling ◽  
Renin Angiotensin System ◽  
Transgenic Rats ◽  
Angiotensin System ◽  
Renin Angiotensin

scholarly journals Addition of ETA receptor blockade increases renoprotection provided by renin–angiotensin system blockade in 5/6 nephrectomized Ren-2 transgenic rats

Life Sciences ◽  
2014 ◽  
Vol 118 (2) ◽  
pp. 297-305 ◽  
Author(s):  
Věra Čertíková Chábová ◽  
Zdenka Vernerová ◽  
Petr Kujal ◽  
Zuzana Husková ◽  
Petra Škaroupková ◽  
...  
Keyword(s):  
Renin Angiotensin System ◽  
Receptor Blockade ◽  
Transgenic Rats ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Eta Receptor

Aging and the brain renin-angiotensin system: insights from studies in transgenic rats.

2007 ◽  
Vol 74 (Suppl_1) ◽  
pp. S95-S95 ◽  
Author(s):  
D. I Diz ◽  
S. O Kasper ◽  
A. Sakima ◽  
C. M Ferrario
Keyword(s):  
Renin Angiotensin System ◽  
Transgenic Rats ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
The Brain

scholarly journals The brain renin-angiotensin system and cardiovascular responses to stress: insights from transgenic rats with low brain angiotensinogen

2012 ◽  
Vol 113 (12) ◽  
pp. 1929-1936 ◽  
Author(s):  
Amy C. Arnold ◽  
Atsushi Sakima ◽  
Sherry O. Kasper ◽  
Sherry Vinsant ◽  
Maria Antonia Garcia-Espinosa ◽  
...  
Keyword(s):  
Stress Responses ◽  
Renin Angiotensin System ◽  
Cardiovascular Responses ◽  
Ang Ii ◽  
Transgenic Rats ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Brain Peptides ◽  
The Impact ◽  
The Brain

The renin-angiotensin system (RAS) has been identified as an attractive target for the treatment of stress-induced cardiovascular disorders. The effects of angiotensin (ANG) peptides during stress responses likely result from an integration of actions by circulating peptides and brain peptides derived from neuronal and glial sources. The present review focuses on the contribution of endogenous brain ANG peptides to pathways involved in cardiovascular responses to stressors. During a variety of forms of stress, neuronal pathways in forebrain areas containing ANG II or ANG-(1–7) are activated to stimulate descending angiotensinergic pathways that increase sympathetic outflow to increase blood pressure. We provide evidence that glia-derived ANG peptides influence brain AT1 receptors. This appears to result in modulation of the responsiveness of the neuronal pathways activated during stressors that elevate circulating ANG peptides to activate brain pathways involving descending hypothalamic projections. It is well established that increased cardiovascular reactivity to stress is a significant predictor of hypertension and other cardiovascular diseases. This review highlights the importance of understanding the impact of RAS components from the circulation, neurons, and glia on the integration of cardiovascular responses to stressors.

scholarly journals Reversible cardiac remodeling after renin‐angiotensin system stimulation in CYP1A1‐Ren2 transgenic rats

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Ben Janssen ◽  
Bart Heijnen ◽  
Leonie Pelkmans ◽  
Jan Danser ◽  
Ingrid Garrelds ◽  
...  
Keyword(s):  
Cardiac Remodeling ◽  
Renin Angiotensin System ◽  
Transgenic Rats ◽  
Angiotensin System ◽  
Renin Angiotensin
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