In vitro and in vivo vascular responses to the L-type calcium channel activator, Bay K 8644, in rats with cirrhosis

1998 ◽  
Vol 13 (12) ◽  
pp. 1254-1258 ◽  
Author(s):  
RICHARD MOREAU ◽  
FREDERIC OBERTI ◽  
PHILIPPE LAHAYE ◽  
ADRIAN GADANO ◽  
STEPHANE CAILMAIL ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Bay K 8644 ◽  
Vascular Responses ◽  
Calcium Channel Activator ◽  
Channel Activator

Calmodulin antagonists inhibit dihydropyridine calcium channel activator (BAY-K-8644) induced cGMP synthesis in pituitary tumor cells

1986 ◽  
Vol 64 (6) ◽  
pp. 760-763 ◽  
Author(s):  
Seymour Heisler
Keyword(s):  
Calcium Channel ◽  
Bay K 8644 ◽  
Dependent Manner ◽  
Calmodulin Antagonists ◽  
Concentration Dependent Manner ◽  
Calcium Channel Activator ◽  
Cgmp Formation ◽  
Cgmp Synthesis ◽  
Channel Activator

The dihydropyridine calcium channel activator, BAY-K-8644, stimulates cGMP formation in ACTH-secreting mouse AtT-20 clonal corticotrophs. The recent report that calmodulin antagonists could inhibit dihydropyridine binding in several tissues suggested that these agents might also affect the cyclic nucleotide response to BAY-K-8644. In fact, TMB-8, trifluoperazine, and melittin, described as in vitro antagonists of calmodulin-dependent enzyme activities, all inhibited BAY-K-8644 induced cGMP synthesis in a concentration-dependent manner. The antagonists had no effect on cGMP formation stimulated by sodium nitroprusside or sodium azide. The calcium channel antagonist, nifedipine, did not stimulate cGMP formation nor did it alter the effect of BAY-K-8644 on accumulation of the nucleotide; one explanation thus is that the cyclase involved in cGMP formation is coupled to a low affinity binding site for BAY-K-8644, which is less accessible to other dihydropyridines. The relation of cyclic GMP formation to the function of the calcium channel in AtT-20 cells remains unknown.

Effects of the Calcium Channel Activator BAY-K-8644 onin VitroSecretion of Calcitonin and Parathyroid Hormone*

Endocrinology ◽  
1986 ◽  
Vol 118 (2) ◽  
pp. 545-549 ◽  
Author(s):  
CARY W. COOPER ◽  
SUSAN A. BOROSKY ◽  
PATRICK E. FARRELL ◽  
ODD S. STEINSLAND
Keyword(s):  
Parathyroid Hormone ◽  
Calcium Channel ◽  
Bay K 8644 ◽  
Calcium Channel Activator ◽  
Channel Activator

Dimemorfan prevents seizures induced by the L-type calcium channel activator BAY k-8644 in mice

2004 ◽  
Vol 151 (1-2) ◽  
pp. 267-276 ◽  
Author(s):  
Eun-Joo Shin ◽  
Toshitaka Nabeshima ◽  
Phil Ho Lee ◽  
Won-Ki Kim ◽  
Kwang Ho Ko ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Bay K 8644 ◽  
Calcium Channel Activator ◽  
Channel Activator

Central and peripheral effects of the dihydropyridine calcium channel activator BAY K 8644 in the rat

1989 ◽  
Vol 160 (3) ◽  
pp. 339-347 ◽  
Author(s):  
Anne Bourson ◽  
Paul C. Moser ◽  
Alma J. Gower ◽  
Anis K. Mir
Keyword(s):  
Calcium Channel ◽  
Bay K 8644 ◽  
Calcium Channel Activator ◽  
Channel Activator

Lack of vascular hyporesponsiveness to the L-type calcium channel activator, Bay K 8644, in rats with cirrhosis

1995 ◽  
Vol 22 (2) ◽  
pp. 202-207 ◽  
Author(s):  
Marek Hartleb ◽  
Richard Moreau ◽  
Christophe Gaudin ◽  
Didier Lebrec
Keyword(s):  
Calcium Channel ◽  
Bay K 8644 ◽  
Calcium Channel Activator ◽  
Channel Activator
Sign in / Sign up

Export Citation Format

Share Document