Lack of association between occult hepatitis B virus DNA viral load and aminotransferase levels in patients with hepatitis C virus-related chronic liver disease

e15199 Background: Occult hepatitis B virus (HBV) infection is characterized by persistence of HBV DNA into the tissue of hepatitis B surface antigen-negative individuals. The clinical relevance of this infection is still under debate. In particular, the impact of occult HBV infection in cases of hepatocellular carcinoma (HCC) is uncertain. Methods: We investigated the prevalence of occult HBV in patients with chronic liver disease, with or without HCC, that were submitted to liver transplantation or partial hepatectomy in Alfa Institute of Gastroenterology from Clinical Hospital - UFMG - Brazil. We tested the presence of VHB DNA in liver sample using nested PCR in four different regions of viral genome (pre-S/S, pre –core/core, polymerase and X). We also tested these patients’serum for HVB antigens (HBsAg and HBeAg)and antibodies (anti-HBs, anti-HBe and anti-HBC). Results: Our studied population included 71 patients, 50 (70.4%) were male and had median age of 51±12.5 years. Cirrhosis etiology was alcoholic (22 cases, 32.4%), viral hepatitis (17 cases, 25%), cryptogenic (16 cases, 23.5%), autoimmune (10 cases, 14.7%) and 3 cases of other etiologies. HCC was found in 22 patients (31.4%). Viral DNA was detected in 4 cases (5.6%), three of them with HCC. Among these three cases viral DNA was found in non-tumoral area in two of them and in HCC sample in the other one. Conclusions: The prevalence of occult hepatitis B infection was high in our population of cirrhotic patients submitted to liver transplant, especially with associated HCC.

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M1903 Hepatitis B Virus DNA in Liver Tissue and Risk for Hepatocarcinogenesis in Patients with Hepatitis C Virus-Related Chronic Liver Disease: A Prospective Study

Gastroenterology ◽

10.1016/s0016-5085(08)63771-3 ◽

2008 ◽

Vol 134 (4) ◽

pp. A-807

Author(s):

Mikako Obika ◽

Toshiyuki Shinji ◽

Shin-ichi Fujioka ◽

Hidenori Shiraha ◽

Ryo Terada ◽

...

Keyword(s):

Hepatitis C Virus ◽

Liver Disease ◽

Hepatitis C ◽

Hepatitis B Virus ◽

Hepatitis B ◽

Prospective Study ◽

Chronic Liver Disease ◽

Liver Tissue ◽

B Virus ◽

A Prospective Study

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Hepatitis B virus subtypes and hepatitis C virus genotypes in patients with chronic liver disease or on maintenance hemodialysis in Indonesia

Journal of Medical Virology ◽

10.1002/jmv.1890430216 ◽

1994 ◽

Vol 43 (2) ◽

pp. 182-186 ◽

Cited By ~ 12

Author(s):

Soeliadi Hadiwandowo ◽

Fumio Tsuda ◽

Hiroaki Okamoto ◽

Hajime Tokita ◽

Yu Wang ◽

...

Keyword(s):

Hepatitis C Virus ◽

Liver Disease ◽

Hepatitis C ◽

Hepatitis B Virus ◽

Hepatitis B ◽

Chronic Liver Disease ◽

Maintenance Hemodialysis ◽

B Virus ◽

Virus Genotypes ◽

Hepatitis C Virus Genotypes

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Chronic Liver Disease in Ethiopia with a Particular Focus on the Etiological Spectrums: A Systematic Review and Meta-Analysis of Observational Studies

Canadian Journal of Gastroenterology and Hepatology ◽

10.1155/2021/8740157 ◽

2021 ◽

Vol 2021 ◽

pp. 1-14

Author(s):

Behailu Terefe Tesfaye ◽

Temesgen Mulugeta Feyissa ◽

Azmeraw Bekele Workneh ◽

Esayas Kebede Gudina ◽

Mengist Awoke Yizengaw

Keyword(s):

Systematic Review ◽

Hepatitis C Virus ◽

Liver Disease ◽

Hepatitis C ◽

Hepatitis B Virus ◽

Hepatitis B ◽

Chronic Liver Disease ◽

Meta Analysis ◽

Chronic Liver ◽

B Virus

Background. In Ethiopia, chronic liver disease (CLD) is the 7th leading cause of death, accounting for about 24 deaths per 100000 populations in 2019. Despite its burden, there is a lack of compiled pieces of evidence on CLD in the country. Thus, this systematic review and meta-analysis is intended to provide the pooled estimates of CLD etiologies and mortality rate in CLD patients in Ethiopia. Method. PubMed, Google Scholar, ScienceDirect, institutional repositories, national digital library, and the bibliography of the eligible articles information were the source of data for the present review. The keywords “hepatitis, chronic” [Mesh], “end-Stage Liver Disease” [Mesh], “chronic liver disease”, “liver cirrhosis” [Mesh], and “Ethiopia” were used for the searches. Overall, we retrieved 199 records and 12 were included in this review. We used the DerSimonian-Laird random-effects models to perform the meta-analysis. We conducted subgroup and meta-regression analyses to account for the heterogeneity of the estimates. Result. Hepatitis B virus, alcohol, and hepatitis C virus are the three most common etiologies of CLD in Ethiopia accounting for a pooled estimate of 40.0% [95% CI: 29.0, 51.0, I2 = 96.3, p < 0.001 ], 17.0% [95% CI: 9.0, 25.0, I2 = 96.7, p < 0.001 ], and 15.0% [95% CI: 9.0, 21.0, I2 = 95.8, p < 0.001 ], respectively. Unidentified etiology report has a substantial contribution accounting for an estimated pooled proportion of 45% [95% CI: 34.0, 56.0%, Q = 32.08, p < 0.001 , I2 = 87.53] of the CLD cases in the country. On the other hand, the overall hospital mortality rate in CLD patients is 25.0% [95% CI: 2.0, 47.0, I2 = 94.6, p < 0.001 ] in Ethiopia. Conclusion. Hepatitis B virus, hepatitis C virus, and alcohol are the three most common contributors to CLD cases in Ethiopia. The authors warrant routine screening and strengthening of preventive and treatment programs for viral hepatitis B and C, further enhancing the alcohol policy of the country.

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