CagA genotype and metronidazole resistant strain of Helicobacter pylori in functional dyspepsia in Thailand

ABSTRACT The rdxA gene of 30 independently isolatedHelicobacter pylori strains was sequenced. A comparison of the rdxA sequences revealed a higher percentage of amino acid substitutions in the corresponding protein than in other housekeeping genes. Out of 122 point mutations, 41 were missense and 4 were nonsense. A resistant strain with a nucleotide insertion in therdxA sequence was also found. With the exception of the point mutations and the insertion generating a stop signal, no particular nucleotide mutation or amino acid substitution could be associated to metronidazole resistance. Moreover, phylogenetic analysis of the 30 nucleotide sequences did not demonstrate specific clusters associated with the resistance phenotype.

Download Full-text

Comparison of Lansoprazole, Amoxicillin and Clarithromycin (LAC) treatment versus Levofloxacin, Omeprazole, Nitazoxanide and Doxycycline (LOND) in eradication of Helicobacter pylori in patients with functional dyspepsia

Medpusle International Journal of Surgery ◽

10.26611/1061832 ◽

2021 ◽

Vol 18 (3) ◽

pp. 58-61

Author(s):

Rahul R Shelke ◽

Keyword(s):

Helicobacter Pylori ◽

Functional Dyspepsia

Download Full-text

A genetic variant of the p22PHOX component of NADPH oxidase C242T is associated with reduced risk of functional dyspepsia in Helicobacter pylori-infected Japanese individuals

European Journal of Gastroenterology & Hepatology ◽

10.1097/meg.0b013e32830e2871 ◽

2009 ◽

Vol 21 (12) ◽

pp. 1363-1368 ◽

Cited By ~ 11

Author(s):

Tomomitsu Tahara ◽

Tomoyuki Shibata ◽

Fangyu Wang ◽

Masakatsu Nakamura ◽

Mikijyu Sakata ◽

...

Keyword(s):

Helicobacter Pylori ◽

Nadph Oxidase ◽

Functional Dyspepsia ◽

Genetic Variant ◽

Reduced Risk

Download Full-text

Helicobacter pylori colonization does not influence the symptomatic response to prokinetic agents in patients with functional dyspepsia

Journal of Gastroenterology and Hepatology ◽

10.1111/j.1440-1746.1998.tb00676.x ◽

1998 ◽

Vol 13 (5) ◽

pp. 500-504 ◽

Cited By ~ 5

Author(s):

CHING-LIANG LU ◽

FULL-YOUNG CHANG ◽

TSENG-SHING CHEN ◽

CHIH-YEN CHEN ◽

KANG LIH JIUN ◽

...

Keyword(s):

Helicobacter Pylori ◽

Functional Dyspepsia ◽

Prokinetic Agents

Download Full-text

The Gastro-protective Effect of Ginger (Zingiber officinale Roscoe) in Helicobacter pylori Positive Functional Dyspepsia

Advanced Pharmaceutical Bulletin ◽

10.15171/apb.2019.038 ◽

2019 ◽

Vol 9 (2) ◽

pp. 321-324 ◽

Cited By ~ 2

Author(s):

Vahideh Ebrahimzadeh Attari ◽

Mohammad Hosein Somi ◽

Mohammad Asghari Jafarabadi ◽

Alireza Ostadrahimi ◽

Seyed-Yaghob Moaddab ◽

...

Keyword(s):

Clinical Trials ◽

Helicobacter Pylori ◽

Functional Dyspepsia ◽

Zingiber Officinale ◽

Complementary Therapy ◽

Positive Functional ◽

Before And After ◽

Rome Iii ◽

Ginger Powder ◽

H Pylori

Purpose: The present study aimed to assess the effect of ginger (Zingiber officinale) powder supplementation on Helicobacter pylori eradication and improvement of dyspeptic symptoms in patients with H. pylori positive functional dyspepsia (FD). Methods: During this pilot study 15 patients with H. pylori positive FD received 3 g/d ginger powder as three 1-g tablets for 4-weeks. Dyspepsia symptoms were asked before and after the intervention using a questionnaire based on the Rome III criteria. H. pylori eradication was also assessed by a non-invasive stool antigen (HpSAg) test. Results: Ginger consumption accompanied by significant H. pylori eradication rate of 53.3% (P = 0.019) and the odds ratio (95% CI) was 8 (1.07 to 357.14). Moreover, our results showed significant changes in most of the dyspepsia symptoms after ginger supplementation. Conclusion: According to our findings, Z. officinale can be considered as a useful complementary therapy for FD. However, due to the small number of clinical trials in this area, further welldesigned clinical trials are needed to explicitly talk about its effectiveness especially about the eradication of H. pylori.

Download Full-text