EFFECTS OF ENALAPRIL AND HYDROCHLOROTHIAZIDE ON BLOOD PRESSURE, RENIN-ANGIOTENSIN SYSTEM, AND ATRIAL NATRIURETIC FACTOR IN ESSENTIAL HYPERTENSION: A DOUBLE BLIND FACTORIAL CROSS-OVER STUDY

1986 ◽  
Vol 16 (4) ◽  
pp. 475-480 ◽  
Author(s):  
J. P. Chalmers ◽  
L. M. H. Wing ◽  
M. J. West ◽  
A. J. C. Bune ◽  
J. M. Elliott ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Atrial Natriuretic Factor ◽  
Renin Angiotensin System ◽  
Double Blind ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Natriuretic Factor ◽  
Atrial Natriuretic

Effect of hypoxia on atrial natriuretic factor and aldosterone regulation in humans

1990 ◽  
Vol 258 (2) ◽  
pp. E243-E248 ◽  
Author(s):  
D. L. Lawrence ◽  
J. B. Skatrud ◽  
Y. Shenker
Keyword(s):  
Atrial Natriuretic Factor ◽  
Acute Hypoxia ◽  
Physiological Role ◽  
Renin Angiotensin System ◽  
Plasma Renin ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Natriuretic Factor ◽  
Hemoglobin Saturation ◽  
Atrial Natriuretic

To evaluate the possible physiological role of atrial natriuretic factor (ANF) on the observed dissociation of aldosterone from the renin-angiotensin system during acute hypoxia, 7 men, ages 18-27 yr, were studied on two separate days for 1 h under hypoxic (12% O2) and normoxic (room air) conditions. Subjects were on a low-salt diet (urinary sodium 67 +/- 13 meq/24 h) and suppressed with dexamethasone. Hemoglobin saturation decreased during hypoxemia to 68 +/- 1% (P less than 0.01), whereas heart rate increased from 65 +/- 3 to 89 +/- 5 beats/min (P less than 0.01). Plasma aldosterone levels decreased 43% from basal during hypoxemia (P less than 0.01), whereas ANF levels increased by 50% (P less than 0.05). Levels of both were unchanged during normoxemia. Plasma renin activity, angiotensin II, blood pressure, and pH did not change under either condition, and plasma cortisol levels were totally suppressed. These results indicate that acute hypoxemia is a potent stimulus for ANF release and that ANF is probably a major factor responsible for the dissociation of aldosterone from the renin-angiotensin system under these conditions.

Atrial natriuretic peptides in essential hypertension: basal plasma levels and relationship to sodium balance

1991 ◽  
Vol 69 (10) ◽  
pp. 1592-1600 ◽  
Author(s):  
G. A. Sagnella ◽  
N. D. Markandu ◽  
M. G. Buckley ◽  
M. A. Miller ◽  
D. R. J. Singer ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Natriuretic Peptides ◽  
Renin Angiotensin System ◽  
Dietary Sodium ◽  
Sodium Balance ◽  
Potential Importance ◽  
Atrial Natriuretic Peptides ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Atrial Natriuretic

The identification of the atrial natriuretic peptides (ANP) as a new hormonal system has provided a new perspective on the mechanisms controlling renal sodium excretion and abnormalities in sodium homeostasis. The present article focuses on the potential importance of ANP (ANF 99–126) in essential hypertension with particular reference to circulating ANP levels and the relationship between the ANP and the renin–angiotensin system in the control of sodium balance and blood pressure. There is now considerable evidence demonstrating that a substantial proportion of patients with essential hypertension have raised circulating ANP levels. Given the known biological actions of ANP, these raised levels point to important compensatory mechanisms. This is further supported by studies during alterations in dietary sodium intake, as sodium restriction highlighted important relationships between ANP and the renin angiotensin system. The potential importance of ANP in essential hypertension is strengthened by recent demonstration of natriuretic and antihypertensive actions associated with small increases in circulating ANP as induced by administration of exogenous ANP. Furthermore, the recent development of orally active inhibitors of ANP metabolism now provides a basis to determine the therapeutic importance of specific manipulation of endogenous ANP levels in patients with essential hypertension.Key words: ANF, essential hypertension, sodium balance.

Effects of Nitrendipine on Blood Pressure, Renin-Angiotensin System, and Kidney Function in Essential Hypertension

1988 ◽  
Vol 12 ◽  
pp. S142-S145 ◽  
Author(s):  
Nicola Glorioso ◽  
Paolo Manunta ◽  
Chiara Troffsa ◽  
Antonio Pazzola ◽  
Aldo Soro ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Kidney Function ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin
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