Pick complex and Pick's disease: the nosology of frontal lobe dementia, primary progressive aphasia, and corticobasal ganglionic degeneration

1996 ◽  
Vol 3 (3) ◽  
pp. 280-282 ◽  
Author(s):  
A. Kertesz
Keyword(s):  
Frontal Lobe ◽  
Primary Progressive Aphasia ◽  
Pick's Disease ◽  
Pick’S Disease ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Frontal Lobe Dementia ◽  
Corticobasal Ganglionic Degeneration

Behavioral and Psychological Symptoms and Frontotemporal Dementia (Pick's Disease)

2000 ◽  
Vol 12 (S1) ◽  
pp. 183-187 ◽  
Author(s):  
Andrew Kertesz
Keyword(s):  
Frontotemporal Dementia ◽  
Frontal Lobe ◽  
Corticobasal Degeneration ◽  
Primary Progressive Aphasia ◽  
Personal Hygiene ◽  
Pick's Disease ◽  
Pick’S Disease ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Frontal Lobe Dementia

Frontotemporal dementia, or Pick's disease, begins with personality and behavioral changes, in contrast to Alzheimer's disease (AD), which begins with memory deficits. Frontotemporal dementia is a term widely used for both the behavioral-personality component of frontal lobe dementia and for the disease itself (Brun et al., 1994). According to consensus criteria developed by the Manchester/Lund group (Brun et al., 1994), the core features of frontal lobe dementia or frontotemporal degeneration are disinhibition, loss of insight, apathy, disorganization, aspontaneity, indifference, lack of personal hygiene, mental rigidity, perseveration, hyperorality, and utilization behaviors. The clinical features of frontal lobe dementia often overlap with those of primary progressive aphasia, a condition characterized by language deficit in the first 2 years of the disease (Mesulam, 1987). Pick's original patient with lobar atrophy was also aphasic (Pick, 1892), and primary progressive aphasia has a course, eventual outcome, and pathology similar to that of frontal lobe dementia (Kertesz et al., 1994). In some patients with primary progressive aphasia, extrapyramidal symptoms similar to those that occur with corticobasal degeneration and motor neuron disease are superimposed.

Pragmatics in frontal lobe dementia and primary progressive aphasia

1998 ◽  
Vol 11 (1-2) ◽  
pp. 153-177 ◽  
Author(s):  
Joseph B. Orange ◽  
Andrew Kertesz ◽  
Jennifer Peacock
Keyword(s):  
Frontal Lobe ◽  
Primary Progressive Aphasia ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Frontal Lobe Dementia

scholarly journals Neuropsychological Profiles Differ among the Three Variants of Primary Progressive Aphasia

2015 ◽  
Vol 21 (6) ◽  
pp. 429-435 ◽  
Author(s):  
Alissa M. Butts ◽  
Mary M. Machulda ◽  
Joseph R. Duffy ◽  
Edythe A. Strand ◽  
Jennifer L. Whitwell ◽  
...  
Keyword(s):  
Frontal Lobe ◽  
Visual Memory ◽  
Primary Progressive Aphasia ◽  
Neuropsychological Evaluation ◽  
Neurocognitive Dysfunction ◽  
Memory Processing ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Frontal Lobe Functions ◽  
Visuospatial Functions

AbstractThe objective of this study was to describe the neuropsychological profiles of the three variants of primary progressive aphasia (PPA). Based on a comprehensive speech and language evaluation, 91 subjects were classified as logopenic (lvPPA=51), semantic (svPPA=13), or agrammatic (agPPA=27). All subjects completed a separate neuropsychological evaluation assessing verbal and visual memory, processing speed, executive function, and visuospatial function. The groups did not differ on demographic variables or on measures of disease duration or aphasia severity. There were group differences on aspects of learning and memory, as well as aspects of executive and visuospatial functions, primarily with the lvPPA group performing lower than the agPPA and svPPA groups. The agPPA group showed subtle deficits consistent with frontal lobe impairment, whereas neurocognitive weaknesses in the svPPA group were restricted to temporal lobe functions. The pattern of neurocognitive dysfunction in lvPPA suggests disease involvement of frontal lobe functions in addition to temporoparietal functions. These neurocognitive findings emphasize the value of a comprehensive neuropsychological evaluation of individuals who present with primary language disturbance, given the pattern of cognitive deficits may provide additive information for differentiating these clinical syndromes. (JINS, 2015, 21, 429–435)

Reply from the Authors: Primary progressive aphasia and frontal lobe involvement

Neurology ◽  
1996 ◽  
Vol 46 (1) ◽  
pp. 290-291 ◽  
Author(s):  
A. Kertesz ◽  
L. Hudson ◽  
I. MacKenzie ◽  
D. Munoz
Keyword(s):  
Frontal Lobe ◽  
Primary Progressive Aphasia ◽  
Progressive Aphasia ◽  
Primary Progressive

scholarly journals PSP-FTD Complex: A Possible Variant of PSP

2020 ◽  
Vol 35 ◽  
pp. 153331752092238
Author(s):  
Sunil Pradhan ◽  
Ruchika Tandon
Keyword(s):  
Progressive Supranuclear Palsy ◽  
Frontotemporal Dementia ◽  
Frontal Lobe ◽  
Primary Progressive Aphasia ◽  
Semantic Dementia ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Variant Type ◽  
Word Finding

Introduction: This study tried to find out type of lobar features found in patients with progressive supranuclear palsy (PSP) and whether they differ from those of frontotemporal dementia (FTD) as both of these are tauopathies. Methods: We studied lobar functions of 45 patients with PSP. Results: Five (11.1%) patients had no lobar feature; 11 (24.4%) had PSP-like features like apathy, frontal release signs, impaired motor Luria written sequences, and fist-edge-palm test; and 29 (64.4%) patients had FTD-like lobar features like disinhibition, poor naming, and word finding difficulty. Among features resembling FTD, behavioural variant type occurred in 31.1%, primary progressive aphasia type occurred in 58.6%, 3.4% patients had semantic dementia type features, and 6.9% were unclassified. Conclusions: Hence, patients with PSP with lobar features may fall in the middle of PSP-FTD spectrum with frontal lobe features typical of PSP (PSP-frontal like) and those with frontal lobe features resembling FTD (PSP-FTD complex) in between.

Primary progressive aphasia and frontal lobe involvement

Neurology ◽  
1996 ◽  
Vol 46 (1) ◽  
pp. 289-290 ◽  
Author(s):  
A. Bianchetti ◽  
G. B. Frisoni ◽  
M. Trabucchi
Keyword(s):  
Frontal Lobe ◽  
Primary Progressive Aphasia ◽  
Progressive Aphasia ◽  
Primary Progressive
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