Prediction of pre-eclampsia, low birth weight for gestational age and prematurity by uterine artery blood flow velocity waveforms in low risk nulliparous women

Author(s):  
Roger A. McMaster-Fay
1995 ◽  
Vol 79 (1) ◽  
pp. 7-14 ◽  
Author(s):  
S. Zamudio ◽  
S. K. Palmer ◽  
T. Droma ◽  
E. Stamm ◽  
C. Coffin ◽  
...  

To determine whether uterine blood flow was reduced and indexes of pelvic blood flow distribution altered in normotensive pregnancy at high (3,100 m) compared with low altitude (1,600 m), we measured uterine, common iliac, and external iliac artery blood flow velocities and diameters in women during pregnancy and again postpartum. Pregnancy increased uterine artery diameter, blood flow velocity, and volumetric flow at both altitudes. Uterine artery blood flow velocity was greater (69.0 +/- 2.2 vs. 59.4 +/- 3.0 cm/s; P < 0.005) but diameter was smaller at 3,100 m than at 1,600 m (2.5 +/- 0.3 mm vs. 3.4 +/- 0.2 mm; P < 0.005), resulting in volumetric flow that was one-third lower at week 36 of pregnancy (203 +/- 48 vs. 312 +/- 22 ml/min, respectively; P < 0.01). Pregnancy increased common iliac blood flow velocity and decreased external iliac artery blood flow velocity at both altitudes. The uterine artery received a smaller percent of common iliac flow at 3,100 than at 1,600 m (46 +/- 7 vs. 74 +/- 6%; P < 0.005). Gestational age was similar but birth weight was lower at 3,100 m than at 1,600 m. Among subjects at 1,600 m, variation in uterine blood flow velocity correlated positively with infant birth weight. We concluded that reduced uterine blood flow and altered pelvic blood flow distribution during pregnancy at high altitude likely contributed to the altitude-associated reduction in infant birth weight.


Neonatology ◽  
2005 ◽  
Vol 87 (3) ◽  
pp. 145-151 ◽  
Author(s):  
Jyothi Swarup ◽  
Robyn Wyman Baker ◽  
Beverly Sobchak Brozanski ◽  
Toby Debra Yanowitz

1988 ◽  
Vol 8 (3) ◽  
pp. 139
Author(s):  
D. H. Chestnut ◽  
L. G. Ostman ◽  
C. R. Weiner ◽  
M. J. Hdez ◽  
J. R. Wang ◽  
...  

1987 ◽  
Vol 7 (2) ◽  
pp. 75
Author(s):  
D. H. Chestnut ◽  
C. P. Weiner ◽  
J. G. Martin ◽  
J. E. Herrig ◽  
J. P. Wang

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