AMINO ACID AND PROTEIN METABOLISM OF THE BRAIN-VII THE PENETRATION OF CHOLINESTERASE INHIBITORS INTO THE NERVOUS SYSTEM OF THE FROG

1961 ◽  
Vol 8 (3-4) ◽  
pp. 189-200 ◽  
Author(s):  
Doris H. Clouet ◽  
Heinrich Waelsch
Keyword(s):  
Nervous System ◽  
Amino Acid ◽  
Protein Metabolism ◽  
Cholinesterase Inhibitors ◽  
The Brain

Amino acid and protein metabolism in the nervous system of the praying mantid

1976 ◽  
Vol 22 (5) ◽  
pp. 649-660 ◽  
Author(s):  
Héctor Maldonado ◽  
Alfonso Tablante ◽  
Norberto Balderrama
Keyword(s):  
Nervous System ◽  
Amino Acid ◽  
Protein Metabolism ◽  
Praying Mantid

AMINO ACID AND PROTEIN METABOLISM OF THE BRAIN?III.

1958 ◽  
Vol 2 (2-3) ◽  
pp. 216-225 ◽  
Author(s):  
S. Furst ◽  
A. Lajtha ◽  
H. Waelsch
Keyword(s):  
Amino Acid ◽  
Protein Metabolism ◽  
The Brain

scholarly journals Homocysteine reduces NMDAR desensitization and differentially modulates peak amplitude of NMDAR currents, depending on GluN2 subunit composition

2013 ◽  
Vol 110 (7) ◽  
pp. 1567-1582 ◽  
Author(s):  
Andrew D. Bolton ◽  
Marnie A. Phillips ◽  
Martha Constantine-Paton
Keyword(s):  
Nervous System ◽  
Amino Acid ◽  
Hippocampal Slices ◽  
Peak Amplitude ◽  
Subunit Composition ◽  
Kidney Cells ◽  
Human Embryonic Kidney ◽  
Human Embryonic Kidney Cells ◽  
The Brain ◽  
Glun2 Subunit

N-methyl-d-aspartate receptors (NMDARs) have been linked to schizophrenia because agents that bind the receptor, like ketamine and phencyclidine, are capable of inducing schizophrenia-like symptoms. Here we show that the amino acid homocysteine (HCY), which is increased in the blood of schizophrenia patients, reduces desensitization of NMDARs in cultured mouse neurons, human embryonic kidney cells transfected with GluN1 + GluN2A, GluN2B, or GluN2D subunits, and hippocampal slices. HCY also alters the peak amplitude of NMDAR currents, depending on the GluN2 subunit the receptor contains; GluN1 + GluN2A-containing NMDARs show an increase in peak amplitude when exposed to HCY, while GluN1 + GluN2B-containing NMDARs show a decrease in peak amplitude. Both peak amplitude and desensitization effects of HCY can be occluded by saturating the NMDAR with glycine. Since glycine concentrations are not saturating in the brain, HCY could play an NMDAR-modulating role in the nervous system. We also show that HCY shares characteristics with glutamate and suggest that HCY affects both the agonist and co-agonist site of the NMDAR.

AMINO ACID AND PROTEIN METABOLISM OF THE BRAIN?I.

1957 ◽  
Vol 1 (3) ◽  
pp. 289-300 ◽  
Author(s):  
A. Lajtha ◽  
S. Furst ◽  
A. Gerstein ◽  
H. Waelsch
Keyword(s):  
Amino Acid ◽  
Protein Metabolism ◽  
The Brain

Effects of prenatal administration of nicotine on amino acid pools, protein metabolism, and nicotine binding in the brain

1982 ◽  
Vol 7 (12) ◽  
pp. 1515-1522 ◽  
Author(s):  
H. Sershen ◽  
M. E. A. Reith ◽  
M. Banay-Schwartz ◽  
A. Lajtha
Keyword(s):  
Amino Acid ◽  
Protein Metabolism ◽  
The Brain
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