Evaluation of Adrenal Suppression of a Lipid Enhanced, Topical Emollient Cream Formulation of Hydrocortisone Butyrate 0.1% in Treating Children with Atopic Dermatitis

2007 ◽  
Vol 24 (1) ◽  
pp. 81-84 ◽  
Author(s):  
Lawrence Eichenfield ◽  
Charles N. Ellis ◽  
David Fivenson ◽  
Adelaide A. Hebert ◽  
Syd Dromgoole ◽  
...  
2003 ◽  
Vol 1 (1) ◽  
pp. 39-42 ◽  
Author(s):  
N. Cassano ◽  
A. Amoruso ◽  
S. Masci ◽  
S. De Paola ◽  
S. Salvatori ◽  
...  

Emollients play an important role in the management of atopic dermatitis (AD). The aim of this study was to evaluate the efficacy and the “steroid-sparing” activity of an emollient cream (Xanthena® cream) in patients with mild to moderate AD. Patients were asked to apply twice a day for 7 days a cream containing hydrocortisone butyrate on the lesionai skin and then to apply Xanthena® cream only on the left side of affected areas. During the 2-month study period, the use of the corticosteroid cream was resumed in case of flare-up in any side. The results obtained show significant differences of both the total severity score and the intensity of each symptom and sign of AD between the skin areas treated with Xanthena® cream and the control areas (P<0.05); a relevant reduction of steroid requirement was also noted in correlation with the use of this emollient cream (P<0.05). A significant improvement was observed even after the first month of therapy for most symptoms, except for excoriations/fissuring, oozing/crusting and burning which improved only at 2 months. Treatment was well-tolerated by the majority of patients; adverse local reactions, mostly transient and of mild intensity, were observed in 7% of cases.


2002 ◽  
Vol 109 (3) ◽  
pp. 547-555 ◽  
Author(s):  
Sakari Reitamo ◽  
Malcolm Rustin ◽  
Thomas Ruzicka ◽  
Frédéric Cambazard ◽  
Kirsti Kalimo ◽  
...  

2009 ◽  
Vol 6 (5) ◽  
pp. 87-90
Author(s):  
V A Revyakina ◽  
A T Surkov ◽  
S T Makarova ◽  
I I Balabolkin ◽  
V A Revyakina ◽  
...  

THE AIM OF THE STUDY WAS To estimate the efficiency and tolerance of daily application of Mustela Stelatopia emollient cream and bath oil as products for care of child's skin in 64 children suffering from atopic dermatitis. Results. The study showed that Mustela Stelatopia had a considerable treatment-and-prophylactic effects resulted to lower dryness and reduced itching. Skin humidity and SCORAD index during the study had expressed positive dynamics in children of the basic group unlike the comparison group


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