Clinical signs of genital papillomavirus infection

702 women were observed: the basic group consisted оf 450patients with sexual-transmitted infections (STI); control group included 252 women without STI. 19 women with oncological diseases of reproductive system were specially examined.The women with genital papillomavirus infection complained of itch, burning, and warts of anogenital area. The most widespread diseases in STI patients were cervical pseudoerosion and endocervicitis. In presence of HPV of high oncogenic risk in these women endocervicitis, vaginal warts and vulvovaginitis were diagnosed.High oncogenic risk of HPV was noticed in all women with the established diagnosis of cervical cancer.

Features of the morphological structure of the placenta in pregnant women with preeclampsia

To study morphological features of the placenta in women in labor, pregnancy which complicated by preeclampsia we studied 26 placentae, of which 17 were from pregnant women with mild to moderate preeclampsia (basic group) and 9 from healthy women (control group). Histologically the study was conducted with methodically recommendations of T.D. Zadorozhnaya et al. for light microscopy. During the study of morphological features of the placenta in women in labor with preeclampsia were installed morphological changes in the placenta, which reflect a tendency to develop compensatory-adaptive reactions following their stress and exhaustion, which is a sign of placental insufficiency. Received data allow claiming a high frequency of development placental insufficiency in pregnant women with risk factors such as chronic salpingo-oophoritis, anemia, late preeclampsia, and inflammation diseases kidney.

Course of labor and condition of the newborn in women affected by benign ovarian tumors

Annotation. According to various estimations, the incidence of adnexal neoplasms during pregnancy makes up from 0.19% to 8.8%. Most of cases are diagnosed in the first trimester and their incidence gradually decreases as the period of pregnancy grows. Depending on their size and location, ovarian tumors may be related to an adverse obstetrical result caused by mechanical influence. They increase the risk of abortion (from 0 to 6%), preterm labor (from 5.8% to 10.4%) and mechanical impediment to labor. Aim – studying the peculiarities of the course of labor and the condition of the newborn of women affected by benign ovarian tumors. We have conducted a complex examination of 67 pregnant women with benign ovarian tumors and tumor-like growths found before pregnancy or in the first trimester of gestation (basic group) and 50 women presenting no ovarian neoplasms or any other severe gynecological or somatic pathology (reference group). To identify the risk factors, the basic group was divided into 2 subgroups. The condition of fetuses was assessed with the use of automated cardiotocography analysis based on the Dawes/Redman criteria, with the calculation of the short-term variability (STV). The mean and standard deviation (M ± m) were evaluated at a significance level of p <0.05. Categorical variables are presented as the absolute number of cases in the group and the frequency in percent – n (%). Tests for differences between independent samples in the case of quantitative variables were performed using Student’s t test, the Mann-Whitney rank test, and in the case of categorical variables using Fisher’s exact test. The obtained results suggest that the course of labor in women affected by benign ovarian neoplasms is characterized by an increased incidence of complications. A significant difference has been established in the incidence of cesarean sections (35.8% vs 8.0% in the reference group, р<0.05), preterm labor (28.4% vs. 6.0%, р<0.05), fetal distress (19.4% vs. 8.0%, р<0.05) and preterm rupture of membranes (17.9% vs. 6.0%, р<0.05). The incidence of almost all complications of labor in Subgroup 1 significantly exceeds the figures from the reference group and the incidence of preterm labor and fetal distress is also higher in comparison with Subgroup 2. The presence of extragenital pathology is a well-known risk factor for perinatal complications, which is also confirmed by our research. A high level of comorbidity of benign ovarian neoplasms with various extragenital diseases also accounts to a certain degree for gestational complications. Thus, pregnancy in women affected by ovarian tumors implies an increased risk of obstetrical and perinatal complications, in particular, threats of miscarriage and preterm labor. The studies of this issue lack systematization, are often controversial and fragmentary. There has been practically no research on the risk factors for such complications and the ways of their prognostication and prevention.

SURGICAL STRATEGY OF PATIENTS WITH STOMACH CANCER COMPLICATED WITH ACUTE GASTRIC BLEEDING

Summary. Objective. Improvement of results of treatment of patients with stomach cancer complicated with acute gastric bleeding. Materials and methods. It was shown the analysis of results of surgical treatment of 252 patients with stomach cancer complicated with acute gastric bleeding, which got the hospital treatment at GI “V. T. Zaycev Institute of General and Urgent Surgery of NAMS of Ukraine“ from 2010 till 2019, aged 29 till 76. All patients randomly divided on 2 groups: the group of control — 129 patients (got the hospital treatment from 2010 till 2014), and the basic group — 123 patients (from 2015 till 2019). Results. The common surgical tactics and operations were used at the group of control. The two-staged active-idividualized surgical tactic was used at the basic group. Radical surgery was performed in 120 (47.6%) cases; in 132 (52,4%) cases – palliative and symptomatic(the 121(48,0%) cases of it was major abdominal surgery). Postoperative complications occurred in 79 patients (31.1%) and postoperative mortality in 7.9% (20 patients) cases. Conclusion. There is the rational of using the two-staged surgical tactic with wide using of minimally invasive procedure for the treatment of patients with stomach cancer complicated with acute gastric bleeding. Using of this tactic leads to increasing of quantity of radical operations from 38(29,2%) at the group of control till 82(72,8%) at the basic group and leads to decreasing post-operative deaths from 8,5 % till 7,2 % respectively.

Prevention of progression of cervical carcinogenesis at the stage of postoperative rehabilitation

The objective: a study the effect of a complex of hyaluronic acid with plant extracts and a polyphenolic component on cell proliferation and the progression of cervical carcinogenesis.Materials and methods. 74 patients with cervical pathology (average age is 29.8 years) formed the basic group and were examined in the clinic “Doctor Alex” (Kharkiv), 62 women of them had diathermoconization, 12 – laser vaporization of the cervix. Histologically, high-grade squamous intraepithelial lesions (HSIL) was detected in 20 patients, low-grade squamous intraepithelial lesions (LSIL) was found in 46 women, and epidermal endocervicosis – in 8 persons.The patients in the basic group during the postoperative period at the stage of healing additionally used vaginal suppositories of hyaluronic acid with plant extracts and polyphenolic component (aloe vera leaf juice, chamomile flower extract, Centella asiatica extract, sea buckthorn oil, tea tree oil, calendula flower extract, epigallocatechin gallate).The comparison group included 112 women (average age is 32.4 years), 31 of them were diagnosed HSIL, 67 – LSIL, 14 – epidermal endocervicosis; laser vaporization was performed in 21 women, diathermoconization – 91. These patients received antiviral therapy. Markers of proliferation p16 and Ki-67 and the presence of human papilloma virus (HPV) were determined in all women of both groups.Results. 6 months after the treatment, there was a decrease in the frequency of HPV in the basic group (from 55.4% to 5.4%) and in the comparison group (from 51.8% to 6.3%), proliferation markers – from 23.0% to 2.7% and from 20.5% to 6.3%, respectively. In the basic group, a more rapid epithelialization of the cervix was established, which after laser vaporization lasted 28.7 days, after diathermoconization – 36.9 days, and in the comparison group these indicators were, respectively, 30.2 and 44.6 days.Conclusions. The use of laser vaporization or diathermoconization of the cervix in the patients with background cervical pathology, LSIL and HSIL in combination with courses of vaginal suppositories containing hyaluronic acid with plant extracts and a polyphenolic component, can significantly reduce the incidence of HPV, leads to a faster recovery of its epithelium and can be comparable in the effectiveness to the combination of laser vaporization / diathermoconization with antiviral therapy.

Teknologi Partisipasi Metode Fasilitasi Pembuatan Keputusan Partisipatif

Metode yang digunakan dalam buku ini adalahTechnology of Participation (ToP), dalam buku ini diterjemahkan menjadi Teknologi Partisipasi. ToP adalah metoda fasilitasi kelompok yang hak ciptanya dimiliki olehInstitute of Cultural Affairs (ICA). Kemudian ICA memberi ijin pada Associates in Rural Development/Governance and Local Democracy (ARD/GOLD) Project, suatu proyek yang didanai USAID di Filipina, untuk menerbitkan suatu manual tentang ToP yang bertitel Technology of Participation (ToP): Basic Group Facilitation Methods Manual. Berdasarkan aturan USAID, bahwa semua material yang dihasilkan oleh proyek yang didanai USAID adalah milik publik, maka ToP dapat digunakan untuk keperluan publik. Dari buku manual tersebut metode ToP diperoleh dan juga kami gunakan sebagai pustaka acuan untuk penulisan buku ini. Buku ini diterbitkan oleh Yayasan Pendidikan dan Pengembangan Sumber Daya Manusia Kabupaten Selayar dalam usaha memperkaya bahan-bahan penguatan masyarakat sipil di Indonesia termasuk Penguatan Masyarakat dalam Penyelenggaraan Kebijakan Publik Daerah.

The relationship between basic group resonance and quantum yield of high efficiency red light fluorescent solutions

The fluorescent solution with a resonance displacement of only 12.8 (cm−1) for the CN functional group gives this film a quantum yield as high as 84.8%.

SURGICAL STRATEGY OF TREATMENT OF PATIENTS WITH STOMACH CANCER COMPLICATED WITH PERFORATION

Summary. Objective. Improvement of results of treatment of patients with stomach cancer complicated with perforation. Materials and methods. It was shown the analysis of results of surgical treatment of 19 patients with stomach cancer complicated with perforation, which got the hospital treatment at GI «V. T. Zaycev Institute of General and Urgent Surgery of NAMS of Ukraine» from 2011 till 2020, aged 18 till 85. All patients randomly divided on 2 groups: the group of control — 9 patients (got the hospital treatment from 2011 till 2015), and the basic group — 10 patients (from 2016 till 2020). Results. The common surgical tactics and operations were used at the group of control. The two-staged active-idividualized surgical tactic, that consist of closure by interrupted sutures at first stage and reconstructive operation at second, was used at the basic group. Radical surgery was performed in 10 (52,6 %) cases; in 9 (47,4 %) cases – palliative and symptomatic. Postoperative complications occurred in 5 patients (26.3 %) and postoperative mortality in 26.3 % (5 patients) cases. Conclusion. There is the rational of using the two-staged surgical tactic. Using of this tactic leads to increasing of quantity of radical operations from 4(21,0 %) at the group of control till 6(31,6 %) at the basic group and leads to decreasing post-operative deaths from 15,8 % till 10,5 % respectively.

SURGICAL STRATEGY OF TREATMENT OF PATIENTS WITH STOMACH CANCER COMPLICATED WITH ACUTE GASTRIC BLEEDING

Summary. Objective. Improvement of results of treatment of patients with stomach cancer complicated with acute gastric bleeding. Materials and methods. It was shown the analysis of results of surgical treatment of 252 patients with stomach cancer complicated with acute gastric bleeding, which got the hospital treatment at GI “V.T. Zaycev Institute of General and Urgent Surgery of NAMS of Ukraine “ from 2010 till 2019, aged 29 till 76. All patients randomly divided on 2 groups: the group of control - 129 patients (got the hospital treatment from 2010 till 2014), and the basic group - 123 patients (from 2015 till 2019). Results. The common surgical tactics and operations were used at the group of control. The two-staged active-idividualized surgical tactic was used at the basic group. Radical surgery was performed in 120 (47.6 %) cases; in 132 (52,4 %) cases – palliative and symptomatic (the 121(48,0 %) cases of it was major abdominal surgery). Postoperative complications occurred in 79 patients (31.1 %) and postoperative mortality in 7.9 % (20 patients) cases. Conclusion. There is the rational of using the two-staged surgical tactic with wide using of minimally invasive procedure for the treatment of patients with stomach cancer complicated with acute gastric bleeding. Using of this tactic leads to increasing of quantity of radical operations from 38(29,2 %) at the group of control till 82(72,8 %) at the basic group and leads to decreasing post-operative deaths from 8,5 % till 7,2 % respectively.

Primary prevention of bleeding esophageal varices in patients with liver cirrhosis

Objective: to evaluate the effectiveness of the application of beta-blockers for primary prevention of bleeding esophageal varices in patients with liver cirrhosis. Material and methods. A retrospective study included 46 patients with liver cirrhosis of various etiology having II-III stage esophageal varices. All the patients were divided into two equal groups. The basic group was made up of 23 (50 %) patients who were prescribed beta-blockers at recommended dosages continuously over the observation period from 2009 till 2018 for the purpose of primary prevention of bleeding esophageal varices. The control group included 23 (50 %) patients with liver cirrhosis in whom the primary prevention of the bleedings was not performed. Results. The assessment of the effectiveness of beta-blockers was performed with two indicators: the frequency of bleeding esophageal varices and their mortality. The application of beta-blockers made it possible to reduce the bleeding frequency from 34.8 % to 13 % (р = 0.10) and the mortality from 21.7 % to 0 % (р = 0.02). Conclusion. In order to detect early stages of esophageal varices, endoscopic screening should be performed for all patients with liver cirrhosis. The presence of II-III stage esophageal varices requires primary prevention of the bleedings. The drug-of-choice are non-selective beta-blockers. Timely and adequately prevention reduces the risk of the bleedings and their mortality.