A 66-Year-Old Man With Subacute Cough and Worsening Dyspnea Previously Diagnosed With COVID-19 Pneumonia

A 66-year-old man presented with subacute cough and worsening dyspnea. Labs were notable for moderate peripheral eosinophilia, and computed tomography (CT) scan demonstrated extensive crazy-paving throughout bilateral upper lung fields. Bronchoalveolar lavage (BAL) revealed macrophages with lipid-filled vacuoles and negative periodic acid-Schiff (PAS) stain. Further history obtained from the patient and family was notable for daily application of commercially available vapor rub to nares and intentional deep inhalation of nebulized fluids containing scented oils. The patient was diagnosed with exogenous lipoid pneumonia through an unusual route of lipid administration.

The influence of the method of manure removal and storage on the quality of organic products

The aim of this article was to compare the quality of manure in different ways of its removal and storage for environmental pollution. The research was conducted in three farms of Kyiv region with different methods of manure removal, storage and processing: using deep long-lasting straw litter (manure removal three times a year); with manure processing in a closed bioreactor-fermenter of the closed type; with manure settling in open lagoons. In all farms, the average annual livestock is 400 dairy cows. Samples for analysis of manure (processing waste) were taken the day before export to the field. The average daily air temperature during sampling was +21.3 °C. In terms of the sum of nitrogen, phosphorus and potassium content in 1 kg of fertilizers, the highest indicators were observed for the variant of keeping in deep litter – 7.69 g. intermediate bioreactors-fermenters observed intermediate values – 6.69 g. The highest moisture content of manure was during storage in the lagoon – by 19.71 % and 1.38 % more compared to the option on deep litter and in the bioreactor-fermenter. The lowest number of weed seeds was for storage in deep litter – 84 pcs/ml, which is 19 and 23 pcs/ml more than for processing in a bioreactor-fermenter and storage in the lagoon. The indicator of weed germination, which is very important from the point of view of future use of manure as an organic fertilizer in general, had positive indicators for all storage (processing) options. The germination rate of weeds for storage in deep litter was 5.72 %, which is 3.14 and 4.42 % less than for processing in a bioreactor-fermenter and in the lagoon. The largest emissions of N2O (nitric oxide) were in the variant of manure storage in the lagoon – 40712.45 kg, which is 39781.88 kg more than in the options of storage in deep litter and in the bioreactor-fermenter. The content of nitrogen, phosphorus, potassium and organic matter of fertilizer obtained from 1 kg of manure from deep litter, exceeded similar indicators of other methods of storage due to daily application of straw.

Treatment of age-related visual impairment with a mitochondrial-acting peptide.

Age-related visual decline and disease due to neural dysfunction are major sources of disability that have resisted effective treatment. In light of evidence that visual impairment and mitochondrial dysfunction advance with age, we characterized age-related decline of spatial visual function in mice and investigated whether treating aged mice with a drug, Elamipretide (SS31), that has been reported to improve mitochondrial function would treat it. Impaired photopic acuity measured with a virtual optokinetic system emerged near 18 months, and declined to ∼40% below normal by 34 months. Daily application of the synthetic peptide Elamipretide, which has high selectivity for mitochondrial membranes that contain cardiolipin, and promotes efficient electron transfer, was able to mitigate visual decline from 18 months. Daily application from 24 months, when acuity was reduced by ∼16%, reversed visual decline and normalized function within 2 months; recovered function that persisted for at least 3 months after treatment was withdrawn. A single treatment at 24 months also delayed subsequent visual decline. Daily application from 32 months took longer to affect change, but enabled substantial improvement within 2 months. The effects of age and Elamipretide treatment on contrast sensitivity were similar to those on acuity, systemic and eye drop applications of Elamipretide had comparable effects, scotopic spatial visual function was largely unaffected by age or treatment, and altered function was independent of variation in optical clarity. These data indicate that Elamipretide treatment adaptively alters the aging visual system, and provide a rationale to investigate whether mitochondrial dysfunction is a treatable pathophysiology of human visual aging and age-related visual disease.

EFFECT OF GHONTAPHALADI VARTHI IN THE MANAGEMENT OF PERIANAL SINUS - A CASE REPORT

Nadi Vrana is a term used to describe the sinus. Sinus is a blind track lined by granulation tissue from an epithelial surface.it can be treated mainly by Ksharasutra therapy and by other methods which include varti, Lepana etc. In Susrutha Samhitha Chikitsasthana first chapter Dwivarineeya chikitsa; it is mentioned that the Vrana Varthi 1can be used in Nadi Vrana where the wound is having minute opening, deep and going into the Mamsadhatu (muscles). In the present case study, a 44-year-old male patient visited the OPD with Grade 1 inter sphincteric sinus in the perianal region and the patient was selected for application of the Ghontaphaladi Varthi. Daily application of Ghontaphaladi Varthi has shown significant changes in the healing of the track and a decrease in the severity of the associated symptoms like pain and discharge. Keywords: Nadi Vrana, Ghontaphaladi Varthi, Sinus

Interventions to Increase Sunscreen Use in Adults: A Review of the Literature

Skin cancers are the most common malignancy in Australia. Regular sunscreen use can reduce the incidence of cutaneous squamous cell carcinomas and actinic keratoses and has been associated with reducing the incidence of basal cell carcinomas and melanomas. However, sunscreen effectiveness is limited by the failure of the population to use it routinely. Interventions that promote the daily application of sunscreen may reduce the morbidity, mortality, and economic burden associated with skin malignancies. We reviewed the literature that examines the effectiveness of interventions to increase routine sunscreen use and found that no one strategy has been shown to be clearly effective in adults and that relatively few studies have aimed to increase routine use in groups at extreme skin cancer risk. Future research should consider how interventions can be best designed and how sunscreen use is measured so that cost-effective, feasible strategies that result in improved sunscreen use in adults can be established.

Fostering bacterial growth in BFT aquaculture tanks by early Nile tilapia stocking

The current study aimed at fostering bacterial growth in BFT aquaculture tanks by early Nile tilapia stocking. Control tanks had no tilapia but received daily applications of dry molasses (NT+) or had tilapia but no C:N ratio adjustment (T-). Experimental tanks had tilapia and received daily application of molasses to adjust the C:N ratio of water to 15:1 (T+). The development of bioflocs in NT+ was insignificant as demonstrated by low levels of settleable solids (SS) and total suspended solids (TSS). Total ammonia nitrogen (TAN) was significantly higher in NT+ than in T+. In the C:N-ratio adjusted tanks, the presence of fish shortened the control of TAN in several days. As nitrite declined in T+, it increased in NT+. The final concentrations of TSS in T+, T- and NT+ were 236 ± 29 mg L-1, 100 ± 32 mg L-1, and 40 ± 22 mg L-1, respectively (p < 0.05). It can be concluded that stable nitrifying and heterotrophic bacterial communities could be attained in BFT aquaculture tanks, before the end of the 4th week of culture, if the bacterial growth is fostered by early Nile tilapia stocking.

Examination regarding the tolerability of the homochord Acidum L(+)-lacticum at a dosage of sixty drops three times daily

In Germany, the commission D recommends in its current dosage guidelines from March 17, 2004, that homeopathic dilutions higher than 24x will be prescribed in a daily application of five drops once. This recommendation is decisive for the German Regulatory Authority. Even though the homochord Acidum L(+)-lacticum 4x/6x/12x/30x/200x contains dilutions above 24x, it is commonly used in clinical practice for over 30 years in a dosage of 60 drops three times daily. In order to explore the clinical safety and tolerability of Acidum L(+)-lacticum 4x/6x/12x/30x/200x at a dosage of 60 drops three times daily, as well as lower dosages, a therapist survey was designed to address the questions. Highly experienced and licensed therapists, including general and alternative practitioners, reported their usual dosage of homochord, incidences of drug reactions, initial homeopathic aggravations as well as the diagnoses that led to the prescription of Acidum L(+)-lacticum 4x/6x/12x/30x/200x. 167 therapist responses were analyzed. Only four therapists reported occurrences that classify as initial aggravation, (2.40 %), compared to 159 with no incidences (95.21 %). Four therapists made no statement. Nevertheless, there were no adverse drug reactions documented in the survey. Consequently, Acidum L(+)-lacticum 4x/6x/12x/30x/200x at a dosage of 60 drops three times daily or lower dosages may be construed to be clinically tolerable and safe. This evidence might lead to further re-evaluations of other homochords, and rigorous clinical trials for its safety and tolerability.

Characterization and Application of Bioactive Glass and Chitosan Nanoparticles for Tooth Enamel Remineralization

We investigated the remineralization of demineralized enamel surfaces through the application of bioactive glass (BG) and chitosan nanoparticles (CNPs). BG and CNPs were immersed in artificial saliva for 7 days. The resulting crystals were analyzed by X-ray diffraction (XRD) and scanning electron microscopy (SEM). Embedded enamel blocks were immersed in demineralization solution and then classified into five treatment groups: (1) No material applied; (2) toothpaste containing NaF (F); (3) CNP hydrogel; (4) distilled water slurry containing BG; and (5) CNP hydrogel containing BG (BG-CNP). The enamel blocks were immersed in an artificial saliva solution for 1 month; each material was applied twice per day. Nanoindentation testing of enamel surfaces was performed during the immersion period. We found that unidirectional rod-shaped crystals formed in the artificial saliva solutions treated with BG and BG-CNP, showing multiple XRD peaks for hydroxyapatite. The mechanical properties of enamel surfaces decreased markedly following immersion in the demineralization solution, and significantly recovered after 1 month of BG-CNP and BG treatment compared to other the specimens. Porous demineralized enamel surfaces were filled with a remineralization layer after immersion in saliva and application of NaF, BG, and CNP-BG. Thus, daily application of CNP-BG or BG facilitates enamel remineralization.

Altered Testicular Histomorphometric and Antioxidant Levels Following In vivo Bisphenol-A Administration

Background: Bisphenol-A (BPA) is a pervasive environmental toxin that is used in the production processes of many consumables and equipment that are in daily application. The aim of this study was to determine the effects of BPA on the structural and functional integrity of the reproductive system in male Wistar rats and its interaction with melatonin. Methods: Adult female rats in pro-estrus phases were mated with adult male rats and the conception determined. The male pups were divided into two groups of A and B. These groups were further subdivided into six subgroups each. They were administered varying low doses of BPA (25 or 50mg/kg) and melatonin (10mg/kg) at neonatal and adolescent ages. The testes, epididymis and blood samples were collected for histological, semen and biochemical investigations, respectively. Results: The results show that BPA caused histological alterations, reduced quality and quantity of sperm cells, and induced oxidative stress at birth and adolescence. Conclusion: Bisphenol A exposure, even at low dose, is toxic to the male reproductive system, and melatonin administration did not significantly improve the alterations caused by the BPA.