This chapter explores cardiovascular, respiratory, gastrointestinal, neurological, and endocrinological emergencies, including headache, breathlessness, chest pain, coma, Glasgow Coma Scale (GCS), shock, sepsis, anaphylactic shock, acute coronary syndrome with ST-elevation, acute coronary syndrome without ST-elevation, severe pulmonary oedema, cardiogenic shock, broad complex tachycardia, narrow complex tachycardia, bradycardia, acute severe asthma, acute exacerbations of COPD, pneumothorax, tension pneumothorax, pneumonia, pulmonary embolism (PE), acute upper GI bleeding, meningitis, encephalitis, cerebral abscess, status epilepticus, head injury, raised intracranial pressure (ICP), diabetic ketoacidosis (DKA), diabetic emergencies, thyroid emergencies, Addisonian crisis, hypopituitary coma, phaeochromocytoma emergencies, acute poisoning, poisons and their antidotes, paracetamol poisoning, salicylate poisoning, burns, hypothermia, and major disasters