MRI-Based Brain Structure Volumes in Temporal Lobe Epilepsy Patients and their Unaffected Siblings: A Preliminary Study

It has been known for some time that brain-derived neurotrophic factor (BDNF) is critical to normal development of the CNS, and more recently, studies also have documented the ability of BDNF to modify adult CNS structure and function. Therefore, it is no surprise that BDNF has been linked to diseases, such as epilepsy, which may involve abnormal cortical development or altered brain structure and function after maturity. This review evaluates the evidence, particularly from recent studies, that BDNF contributes to the development of temporal lobe epilepsy (TLE).

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A preliminary study, using electron and light-microscopic methods, of axon numbers in the fornix in autopsies of patients with temporal lobe epilepsy

Anatomical Science International ◽

10.1007/s12565-008-0001-2 ◽

2009 ◽

Vol 84 (1-2) ◽

pp. 2-6 ◽

Cited By ~ 9

Author(s):

Omer Ozdogmus ◽

Safiye Cavdar ◽

Yasemin Ersoy ◽

Feriha Ercan ◽

Ibrahim Uzun

Keyword(s):

Temporal Lobe Epilepsy ◽

Temporal Lobe ◽

Preliminary Study

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Brain structure and aging in chronic temporal lobe epilepsy

Epilepsia ◽

10.1111/j.1528-1167.2012.03447.x ◽

2012 ◽

Vol 53 (6) ◽

pp. 1033-1043 ◽

Cited By ~ 25

Author(s):

Kevin Dabbs ◽

Tara Becker ◽

Jana Jones ◽

Paul Rutecki ◽

Michael Seidenberg ◽

...

Keyword(s):

Temporal Lobe Epilepsy ◽

Temporal Lobe ◽

Brain Structure

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The Neurodevelopmental Impact of Childhood-onset Temporal Lobe Epilepsy on Brain Structure and Function

Epilepsia ◽

10.1046/j.1528-1157.2002.49901.x ◽

2002 ◽

Vol 43 (9) ◽

pp. 1062-1071 ◽

Cited By ~ 179

Author(s):

Bruce Hermann ◽

Michael Seidenberg ◽

Brian Bell ◽

Paul Rutecki ◽

Raj Sheth ◽

...

Keyword(s):

Temporal Lobe Epilepsy ◽

Temporal Lobe ◽

Brain Structure ◽

Structure And Function ◽

Childhood Onset ◽

Brain Structure And Function ◽

And Function

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Volumetric glutamate imaging (GluCEST) using 7T MRI can lateralize nonlesional temporal lobe epilepsy: A preliminary study

Brain and Behavior ◽

10.1002/brb3.2134 ◽

2021 ◽

Author(s):

Peter N. Hadar ◽

Lohith G. Kini ◽

Ravi Prakash Reddy Nanga ◽

Russell T. Shinohara ◽

Stephanie H. Chen ◽

...

Keyword(s):

Temporal Lobe Epilepsy ◽

Temporal Lobe ◽

Preliminary Study

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Neuropsychology and Temporal Lobe Epilepsy

CNS Spectrums ◽

10.1017/s1092852900017806 ◽

2002 ◽

Vol 7 (5) ◽

pp. 343-348 ◽

Cited By ~ 17

Author(s):

Bruce Hermann ◽

Michael Seidenberg

Keyword(s):

Magnetic Resonance Imaging ◽

Temporal Lobe Epilepsy ◽

Temporal Lobe ◽

Brain Structure ◽

Resonance Imaging ◽

Quantitative Magnetic Resonance Imaging ◽

Psychosocial Status ◽

Temporal Lobes ◽

Brain Changes ◽

Structural Brain

ABSTRACTThe purpose of this article is to review aspects of the neuropsychology of temporal lobe epilepsy. Evidence will be presented to demonstrate that the cognitive consequences of this focal seizure disorder can be more generalized in nature than expected. Consistent with the extratemporal neurocognitive findings, careful quantitative magnetic resonance imaging volumetrics have shown that structural brain changes may be detected outside the temporal lobes. Many factors can potentially affect cognition and brain structure. We focus on the potential neurodevelopmental impact of early-onset temporal lobe epilepsy on brain structure and cognition positing that this disorder can have both immediate and lifespan implications for cognition and psychosocial status.

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