Tissue Disposition of Carbon Disulfide. II. Whole-Body Autoradiography of 35S- and 14C-labelled Carbon Disulfide in Pregnant Mice

2009 ◽  
Vol 54 (3) ◽  
pp. 233-240 ◽  
Author(s):  
Bengt R. G. Danielsson ◽  
Kerstin Bergman ◽  
Roland D'Argy
Keyword(s):  
Carbon Disulfide ◽  
Whole Body ◽  
Whole Body Autoradiography ◽  
Tissue Disposition ◽  
Pregnant Mice

Blut-Hirn-Schranke und Placentar-Schranke für H-Thymidin und H-Cytidin bei der Maus / Blood-Brain-Barrier and Placental-Barrier for H-Thymidine and H-Cytidine in the Mouse

1972 ◽  
Vol 27 (5) ◽  
pp. 554-558b ◽  
Author(s):  
B. Schultze ◽  
N. Hörning ◽  
W. Maurer
Keyword(s):  
Blood Brain Barrier ◽  
Intravenous Injection ◽  
Brain Barrier ◽  
Whole Body ◽  
Placental Barrier ◽  
Whole Body Autoradiography ◽  
Blood Brain ◽  
Pregnant Mice ◽  
Distribution In The Organism

The distribution in the organism of the mouse of free 3H-thymidine and 3H-cytidine was studied 1, 2½, 5 and 15 minutes after intravenous injection into normal and pregnant mice (20th day) using whole body autoradiography. The grain density measured over brain and fetus is 10 times smaller as compared to other tissues of the organism. This means that a blood brain barrier and placental barrier for thymidine and cytidine exists.

STUDIES ON THE TISSUE-DISPOSITION AND FATE OF [14C]STREPTOZOTOCIN WITH SPECIAL REFERENCE TO THE PANCREATIC ISLETS

1978 ◽  
Vol 89 (2) ◽  
pp. 339-351 ◽  
Author(s):  
Eva Britt Johansson ◽  
Hans Tjälve
Keyword(s):  
Pancreatic Islets ◽  
High Capacity ◽  
Whole Body ◽  
Side Chain ◽  
High Accumulation ◽  
Methyl Group ◽  
Whole Body Autoradiography ◽  
Selective Labelling ◽  
Chinese Hamsters ◽  
Tissue Disposition

ABSTRACT The tissue-disposition and fate of [14C]streptozotocin, labelled in the methyl-group of the N-nitrosomethylurea side-chain, have been studied in mice. Whole-body autoradiography, quantified by densitometric measurements, showed that the pancreatic islets had a high capacity to accumulate radioactivity after the injection of [14C]streptozotocin. Microautoradiography of the pancreas showed that centrally located cells were labelled while peripherally located cells contained a low labelling, indicating a selective labelling of the β-cells. A high radioactivity was present in the liver and the cortex of the kidney at most survival intervals. About 17 % of the radioactivity was exhaled as 14CO2 during 6 h, which shows that the methyl group of the N-nitrosomethylurea side-chain is split off. Radioactivity was shown to be incorporated in the acid-insoluble precipitate of the pancreatic islets, the liver, the kidney, and the exocrine pancreas. This may, to a varying extent, be due both to alkylating reactions and to incorporation of radioactivity in the macromolecules of the tissues via normal metabolic pathways. About 44 % of the radioactivity was excreted as unchanged [14C]streptozotocin in the urine during 24 h, while about 1 % of the radioactivity was found in the faeces. Whole-body autoradiography of [14C]streptozotocin in two Chinese hamsters and one rat also showed a high accumulation of radioactivity in the pancreatic islets in these species.

Distribution of Radioactive Iron in Pregnant Mice Studied by Whole Body Autoradiography

1961 ◽  
Vol Original Series, Volume 55 (2) ◽  
pp. 145-155
Author(s):  
S. Ullberg ◽  
B. Sorbo ◽  
C.-J. Clemedson
Keyword(s):  
Whole Body ◽  
Whole Body Autoradiography ◽  
Pregnant Mice

Distribution of Radioactive Iron in Pregnant Mice Studied by Whole Body Autoradiography

1961 ◽  
Vol 55 (2) ◽  
pp. 145-155 ◽  
Author(s):  
Sven Ullberg ◽  
Bo Sorbo ◽  
Carl-Johan Clemedson
Keyword(s):  
Whole Body ◽  
Whole Body Autoradiography ◽  
Pregnant Mice

scholarly journals Distribution of 203Hg Labeled Mercury Compounds in Adult and Pregnant Mice Determined by Whole-Body Autoradiography

RADIOISOTOPES ◽  
1967 ◽  
Vol 16 (9) ◽  
pp. 439-448 ◽  
Author(s):  
Tyunosin UKITA ◽  
Yasushi TAKEDA ◽  
Yoshishige SATO ◽  
Tadao TAKAHASHI
Keyword(s):  
Whole Body ◽  
Mercury Compounds ◽  
Whole Body Autoradiography ◽  
Pregnant Mice

Whole-body autoradiography of the distribution of β-aminopropionitrile in pregnant mice and rat fetuses

Teratology ◽  
1974 ◽  
Vol 9 (2) ◽  
pp. 211-216 ◽  
Author(s):  
William J. Waddell ◽  
A. L. Wilk ◽  
Robert M. Pratt ◽  
A. J. Steffek ◽  
Keyword(s):  
Whole Body ◽  
Rat Fetuses ◽  
Whole Body Autoradiography ◽  
Pregnant Mice
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