Characterization of a New Class of Thermophilic Pullulanases from Bacillus acidopullulyticus

The genomic characterization of acute myeloid leukemia (AML) by DNA sequencing has illuminated subclasses of the disease, with distinct driver mutations, that might be responsive to targeted therapies. Approximately 15-23% of AML genomes harbor mutations in one of two isoforms of isocitrate dehydrogenase (IDH1 or IDH2). These enzymes are constitutive mediators of basic cellular metabolism, but their mutated forms in cancer synthesize an abnormal metabolite, 2- hydroxyglutarate, that in turn acts as a competitive inhibitor of multiple gene regulatory enzymes. As a result, leukemic IDH mutations cause changes in genome structure and gene activity, culminating in an arrest of normal myeloid differentiation. These discoveries have motivated the development of a new class of selective small molecules with the ability to inhibit the mutant IDH enzymes while sparing normal cellular metabolism. These agents have shown promising anti-leukemic activity in animal models and early clinical trials, and are now entering Phase 3 study. This review will focus on the growing preclinical and clinical data evaluating IDH inhibitors for the treatment of IDH-mutated AML. These data suggest that inducing cellular differentiation is central to the mechanism of clinical efficacy for IDH inhibitors, while also mediating toxicity for patients who experience IDH Differentiation Syndrome. Ongoing trials are studying the efficacy of IDH inhibitors in combination with other AML therapies, both to evaluate potential synergistic combinations as well as to identify the appropriate place for IDH inhibitors within existing standard-of-care regimens.

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Characterization of new regulatory mutants of bacteriophage T4. II. New class of mutants.

Journal of Virology ◽

10.1128/jvi.15.4.929-945.1975 ◽

1975 ◽

Vol 15 (4) ◽

pp. 929-945 ◽

Cited By ~ 15

Author(s):

K V Chace ◽

D H Hall

Keyword(s):

Bacteriophage T4 ◽

Regulatory Mutants ◽

New Class

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Characterization of the Antibiotic Compound No. 70 Produced byStreptomycessp. IMV-70

The Scientific World JOURNAL ◽

10.1100/2012/594231 ◽

2012 ◽

Vol 2012 ◽

pp. 1-8 ◽

Cited By ~ 3

Author(s):

Lyudmila P. Trenozhnikova ◽

Almagul K. Khasenova ◽

Assya S. Balgimbaeva ◽

Galina B. Fedorova ◽

Genrikh S. Katrukha ◽

...

Keyword(s):

Optimal Growth ◽

Growth Conditions ◽

Culture Broth ◽

Producer Strain ◽

New Class ◽

New Antibiotics ◽

Actinomycete Strain ◽

Main Component

We describe the actinomycete strain IMV-70 isolated from the soils of Kazakhstan, which produces potent antibiotics with high levels of antibacterial activity. After the research of its morphological, chemotaxonomic, and cultural characteristics, the strain with potential to be developed further as a novel class of antibiotics with chemotherapeutics potential was identified asStreptomycessp. IMV-70. In the process of fermentation, the strainStreptomycesspp. IMV-70 produces the antibiotic no. 70, which was isolated from the culture broth by extraction with organic solvents. Antibiotic compound no. 70 was purified and separated into individual components by HPLC, TLC, and column chromatography methods. The main component of the compound is the antibiotic 70-A, which was found to be identical to the peptolide etamycin A. Two other antibiotics 70-B and 70-C have never been described and therefore are new antibiotics. The physical-chemical and biological characteristics of these preparations were described and further researched. Determination of the optimal growth conditions to cultivate actinomycete-producer strain IMV-70 and development of methods to isolate, purify, and accumulate preparations of the new antibiotic no. 70 enable us to research further the potential of this new class of antibiotics.

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Synthesis and Characterization of [Zn(SEt)Et]10, Formed via Insertion of Sulfur into Zn-C Bonds: A New Class of Wurtzite-like Cluster Framework

Inorganic Chemistry ◽

10.1021/ic00102a005 ◽

1994 ◽

Vol 33 (24) ◽

pp. 5376-5377 ◽

Cited By ~ 20

Author(s):

Dongshui Zeng ◽

Mark J. Hampden-Smith ◽

Eileen N. Duesler

Keyword(s):

Synthesis And Characterization ◽

New Class

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HIGH DIMENSIONAL KNOT GROUPS AND HNN EXTENSIONS OF THE FIBONACCI GROUPS

Journal of Knot Theory and Its Ramifications ◽

10.1142/s0218216598000267 ◽

1998 ◽

Vol 07 (04) ◽

pp. 503-508 ◽

Cited By ~ 4

Author(s):

ANDRZEJ SZCZEPAŃSKI

Keyword(s):

High Dimensional ◽

New Class ◽

Hnn Extensions

We shall present a new class of examples of high dimensional knot groups. All of them are HNN extensions of the Fibonacci groups. We give also some characterization of these groups.

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