Comparison of Structural Synaptic Modifications Induced by Long-Term Potentiation in the Hippocampal Dentate Gyrus of Young Adult and Aged Rats

2006 ◽  
Vol 747 (1) ◽  
pp. 452-466 ◽  
Author(s):  
YURI GEINISMAN ◽  
LEYLA DeTOLEDO-MORRELL ◽  
FRANK MORRELL
Keyword(s):  
Young Adult ◽  
Dentate Gyrus ◽  
Long Term Potentiation ◽  
Aged Rats ◽  
Hippocampal Dentate Gyrus ◽  
Term Potentiation

scholarly journals Compensatory network changes in the dentate gyrus restore long-term potentiation following ablation of neurogenesis in young-adult mice

2011 ◽  
Vol 108 (13) ◽  
pp. 5437-5442 ◽  
Author(s):  
B. H. Singer ◽  
A. E. Gamelli ◽  
C. L. Fuller ◽  
S. J. Temme ◽  
J. M. Parent ◽  
...  
Keyword(s):  
Young Adult ◽  
Dentate Gyrus ◽  
Long Term Potentiation ◽  
Adult Mice ◽  
Term Potentiation

scholarly journals Long-term potentiation expands information content of hippocampal dentate gyrus synapses

2018 ◽  
Vol 115 (10) ◽  
pp. E2410-E2418 ◽  
Author(s):  
Cailey Bromer ◽  
Thomas M. Bartol ◽  
Jared B. Bowden ◽  
Dusten D. Hubbard ◽  
Dakota C. Hanka ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Dentate Gyrus ◽  
Storage Capacity ◽  
Unit Length ◽  
Long Term Potentiation ◽  
Information Storage ◽  
Perforant Path ◽  
Hippocampal Dentate Gyrus ◽  
Term Potentiation

An approach combining signal detection theory and precise 3D reconstructions from serial section electron microscopy (3DEM) was used to investigate synaptic plasticity and information storage capacity at medial perforant path synapses in adult hippocampal dentate gyrus in vivo. Induction of long-term potentiation (LTP) markedly increased the frequencies of both small and large spines measured 30 minutes later. This bidirectional expansion resulted in heterosynaptic counterbalancing of total synaptic area per unit length of granule cell dendrite. Control hemispheres exhibited 6.5 distinct spine sizes for 2.7 bits of storage capacity while LTP resulted in 12.9 distinct spine sizes (3.7 bits). In contrast, control hippocampal CA1 synapses exhibited 4.7 bits with much greater synaptic precision than either control or potentiated dentate gyrus synapses. Thus, synaptic plasticity altered total capacity, yet hippocampal subregions differed dramatically in their synaptic information storage capacity, reflecting their diverse functions and activation histories.

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