Cytotoxic Efficacy with Combinations of Topoisomerase I and Topoisomerase II Inhibitors in Sensitive and Multidrugresistant L1210 Mouse Leukemia Cells

1996 ◽  
Vol 803 (1 The Camptothe) ◽  
pp. 306-307 ◽  
Author(s):  
DALE GRABOWSKI ◽  
RAM GANAPATHI
Keyword(s):  
Topoisomerase I ◽  
Topoisomerase Ii ◽  
Leukemia Cells ◽  
Mouse Leukemia ◽  
Topoisomerase Ii Inhibitors ◽  
L1210 Mouse Leukemia

Suppression of P-glycoprotein expression by antipsychotics trifluoperazine in adriamycin-resistant L1210 mouse leukemia cells

2006 ◽  
Vol 28 (4) ◽  
pp. 300-306 ◽  
Author(s):  
Soon Young Shin ◽  
Byeong Hyeok Choi ◽  
Jae-Ryong Kim ◽  
Jung-Hye Kim ◽  
Young Han Lee
Keyword(s):  
Leukemia Cells ◽  
Mouse Leukemia ◽  
P Glycoprotein ◽  
L1210 Mouse Leukemia

Inhibitors of topoisomerases do not block the passage of human lymphocyte chromosomes through mitosis

1992 ◽  
Vol 103 (1) ◽  
pp. 105-115
Author(s):  
A.T. Sumner
Keyword(s):  
Chromosome Segregation ◽  
Human Lymphocyte ◽  
Topoisomerase I ◽  
Topoisomerase Ii ◽  
Human Lymphocytes ◽  
Chromosome Breakage ◽  
Chromosome Condensation ◽  
Complete Fusion ◽  
Topoisomerase Inhibitors ◽  
Topoisomerase Ii Inhibitors

Cultured human lymphocytes have been treated with a number of topoisomerase inhibitors, to see whether topoisomerase II is involved in the process of chromosome segregation at anaphase. Results were assessed by examination of cytogenetical preparations of spread chromosomes. Four effects were observed, although no inhibitor produced all four effects. These effects were: inhibition of entry into mitosis; chromosome breakage and rearrangement; inhibition of chromosome condensation; and inhibition of chromosome segregation. Evidence for the last was ambiguous. Although there was evidence that separation of chromatids was affected when cells were treated with colchicine as well as topoisomerase II inhibitors (most notably with nalidixic acid, which resulted in complete fusion of the chromatids), no evidence was obtained to show that, in the absence of colchicine, cells treated with inhibitors could not proceed through anaphase normally. The topoisomerase I inhibitor, camptothecin, differed from the topoisomerase II inhibitors in not showing any effect on chromosome condensation or any significant effect on segregation.

Transport of folate compounds, pterins and adenine in L1210 mouse leukemia cells

1982 ◽  
Vol 20 ◽  
pp. 389-408 ◽  
Author(s):  
F.M. Huennekens ◽  
M.R. Suresh ◽  
K.S. Vitols ◽  
G.B. Henderson
Keyword(s):  
Leukemia Cells ◽  
Mouse Leukemia ◽  
L1210 Mouse Leukemia

Overexpression of P-glycoprotein and alterations in topoisomerase II in P388 mouse leukemia cells selected in vivo for resistance to mitoxantrone

1992 ◽  
Vol 44 (5) ◽  
pp. 937-945 ◽  
Author(s):  
Narayana Kamath ◽  
Dale Grabowski ◽  
Jeanne Ford ◽  
Donna Kerrigan ◽  
Yves Pommier ◽  
...  
Keyword(s):  
Topoisomerase Ii ◽  
Leukemia Cells ◽  
Mouse Leukemia ◽  
P Glycoprotein

Novel Angular Benzophenazines:  Dual Topoisomerase I and Topoisomerase II Inhibitors as Potential Anticancer Agents

2002 ◽  
Vol 45 (3) ◽  
pp. 721-739 ◽  
Author(s):  
Nigel Vicker ◽  
Luke Burgess ◽  
Irina S. Chuckowree ◽  
Rory Dodd ◽  
Adrian J. Folkes ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Topoisomerase I ◽  
Topoisomerase Ii ◽  
Topoisomerase Ii Inhibitors
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