Effect of the calmodulin inhibitor trifluoperazine on phosphorylation of P-glycoprotein and topoisomerase II: Relationship to modulation of subcellular distribution, DNA damage and cytotoxicity of doxorubicin in multidrug resistant L1210 mouse leukemia cells

Ram Ganapathi; Narayana Kamath; Andreas Constantinou; Dale Grabowski; Jeanne Ford; Austin Anderson

doi:10.1016/0006-2952(91)90115-l

Effect of the calmodulin inhibitor trifluoperazine on phosphorylation of P-glycoprotein and topoisomerase II: Relationship to modulation of subcellular distribution, DNA damage and cytotoxicity of doxorubicin in multidrug resistant L1210 mouse leukemia cells

Biochemical Pharmacology ◽

10.1016/0006-2952(91)90115-l ◽

1991 ◽

Vol 41 (12) ◽

pp. R21-R26 ◽

Cited By ~ 11

Author(s):

Ram Ganapathi ◽

Narayana Kamath ◽

Andreas Constantinou ◽

Dale Grabowski ◽

Jeanne Ford ◽

...

Keyword(s):

Dna Damage ◽

Subcellular Distribution ◽

Topoisomerase Ii ◽

Multidrug Resistant ◽

Leukemia Cells ◽

Mouse Leukemia ◽

P Glycoprotein ◽

Calmodulin Inhibitor ◽

L1210 Mouse Leukemia

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Suppression of P-glycoprotein expression by antipsychotics trifluoperazine in adriamycin-resistant L1210 mouse leukemia cells

European Journal of Pharmaceutical Sciences ◽

10.1016/j.ejps.2006.03.002 ◽

2006 ◽

Vol 28 (4) ◽

pp. 300-306 ◽

Cited By ~ 23

Author(s):

Soon Young Shin ◽

Byeong Hyeok Choi ◽

Jae-Ryong Kim ◽

Jung-Hye Kim ◽

Young Han Lee

Keyword(s):

Leukemia Cells ◽

Mouse Leukemia ◽

P Glycoprotein ◽

L1210 Mouse Leukemia

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Cytotoxic Efficacy with Combinations of Topoisomerase I and Topoisomerase II Inhibitors in Sensitive and Multidrugresistant L1210 Mouse Leukemia Cells

Annals of the New York Academy of Sciences ◽

10.1111/j.1749-6632.1996.tb26400.x ◽

1996 ◽

Vol 803 (1 The Camptothe) ◽

pp. 306-307 ◽

Cited By ~ 7

Author(s):

DALE GRABOWSKI ◽

RAM GANAPATHI

Keyword(s):

Topoisomerase I ◽

Topoisomerase Ii ◽

Leukemia Cells ◽

Mouse Leukemia ◽

Topoisomerase Ii Inhibitors ◽

L1210 Mouse Leukemia

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Overexpression of P-glycoprotein and alterations in topoisomerase II in P388 mouse leukemia cells selected in vivo for resistance to mitoxantrone

Biochemical Pharmacology ◽

10.1016/0006-2952(92)90126-4 ◽

1992 ◽

Vol 44 (5) ◽

pp. 937-945 ◽

Cited By ~ 14

Author(s):

Narayana Kamath ◽

Dale Grabowski ◽

Jeanne Ford ◽

Donna Kerrigan ◽

Yves Pommier ◽

...

Keyword(s):

Topoisomerase Ii ◽

Leukemia Cells ◽

Mouse Leukemia ◽

P Glycoprotein

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Differential effect of the calmodulin inhibitor trifluoperazine in modulating cellular accumulation, retention and cytotoxicity of doxorubicin in progressively doxorubicin-resistant L1210 mouse leukemia cells

Biochemical Pharmacology ◽

10.1016/0006-2952(88)90716-2 ◽

1988 ◽

Vol 37 (2) ◽

pp. 185-193 ◽

Cited By ~ 21

Author(s):

Ram Ganapathi ◽

Dale Grabowski

Keyword(s):

Differential Effect ◽

Leukemia Cells ◽

Mouse Leukemia ◽

Cellular Accumulation ◽

Calmodulin Inhibitor ◽

L1210 Mouse Leukemia

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An early enlargement of the putrescine pool is required for growth in L1210 mouse leukemia cells under hypoosmotic stress.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)38096-7 ◽

1991 ◽

Vol 266 (10) ◽

pp. 6142-6151

Author(s):

R Poulin ◽

R S Wechter ◽

A E Pegg

Keyword(s):

Leukemia Cells ◽

Mouse Leukemia ◽

Hypoosmotic Stress ◽

L1210 Mouse Leukemia

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The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism

Leukemia ◽

10.1038/leu.2008.79 ◽

2008 ◽

Vol 22 (6) ◽

pp. 1106-1116 ◽

Cited By ~ 100

Author(s):

F Chiarini ◽

M Del Sole ◽

S Mongiorgi ◽

G C Gaboardi ◽

A Cappellini ◽

...

Keyword(s):

Acute Leukemia ◽

Multidrug Resistant ◽

Leukemia Cells ◽

The Novel ◽

Akt Inhibitor ◽

P Glycoprotein ◽

Dependent Mechanism

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Transport of folate compounds, pterins and adenine in L1210 mouse leukemia cells

Advances in Enzyme Regulation ◽

10.1016/0065-2571(82)90027-9 ◽

1982 ◽

Vol 20 ◽

pp. 389-408 ◽

Cited By ~ 5

Author(s):

F.M. Huennekens ◽

M.R. Suresh ◽

K.S. Vitols ◽

G.B. Henderson

Keyword(s):

Leukemia Cells ◽

Mouse Leukemia ◽

L1210 Mouse Leukemia

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Phosphorylation of RNA Helicase A by DNA-Dependent Protein Kinase Is Indispensable for Expression of theMDR1Gene Product P-Glycoprotein in Multidrug-Resistant Human Leukemia Cells†

Biochemistry ◽

10.1021/bi700063b ◽

2007 ◽

Vol 46 (19) ◽

pp. 5766-5775 ◽

Cited By ~ 9

Author(s):

Xiaoling Zhong ◽

Ahmad R. Safa

Keyword(s):

Protein Kinase ◽

Rna Helicase ◽

Multidrug Resistant ◽

Leukemia Cells ◽

Human Leukemia ◽

Dependent Protein Kinase ◽

Rna Helicase A ◽

Human Leukemia Cells ◽

P Glycoprotein ◽

Dependent Protein

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Increased P-glycoprotein expression and multidrug-resistant gene (mdr1) amplification are infrequently found in fresh acute leukemia cells. Sequential analysis of 15 cases at initial presentation and relapsed stage

Cancer ◽

10.1002/1097-0142(19890415)63:8<1534::aid-cncr2820630813>3.0.co;2-n ◽

1989 ◽

Vol 63 (8) ◽

pp. 1534-1538 ◽

Cited By ~ 61

Author(s):

Yoshinori Ito ◽

Mitsune Tanimoto ◽

Takao Kumazawa ◽

Masao Okumura ◽

Yasuo Morishima ◽

...

Keyword(s):

Acute Leukemia ◽

Sequential Analysis ◽

Multidrug Resistant ◽

Initial Presentation ◽

Leukemia Cells ◽

Resistant Gene ◽

P Glycoprotein

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Folate metabolism in mammalian cells in culture. I Partial characterization of the folate derivatives present in L1210 mouse leukemia cells.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)33382-3 ◽

1976 ◽

Vol 251 (12) ◽

pp. 3569-3575

Author(s):

R G Moran ◽

W C Werkheiser ◽

S F Zakrzewski

Keyword(s):

Mammalian Cells ◽

Folate Metabolism ◽

Partial Characterization ◽

Leukemia Cells ◽

Mouse Leukemia ◽

Cells In Culture ◽

L1210 Mouse Leukemia

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