Optic disc pit: clinical and swept source optical coherence tomography characteristics

Abstract Background To understand the differences between two different optical coherence tomography angiography (OCTA) devices in detecting glaucomatous from healthy eyes by comparing their vascular parameters, diagnostic accuracy and test-retest reliability. Methods A cross-sectional observational study was performed on healthy and glaucoma subjects, on whom two sets of OCTA images of optic disc and macula were acquired using both AngioVue (Optovue, USA) and Swept Source (Topcon, Japan) OCTA devices during one visit. A novel in-house software was used to calculate the vessel densities. Diagnostic accuracy of the machines in differentiating healthy versus glaucomatous eyes was determined using area under the receiver operating characteristic curve (AUROC) and test-retest repeatability of the machines was also evaluated. Results A total of 80 healthy and 38 glaucomatous eyes were evaluated. Glaucomatous eyes had reduced mean vessel density compared to healthy controls in all segmented layers of the optic disc and macula using AngioVue (p ≤ 0.001). However, glaucomatous eyes had higher mean vessel density on optic disc scans using Swept Source, with lack of statistically significant difference between healthy and glaucomatous eyes. The AUROC showed better diagnostic accuracy of AngioVue (0.761–1.000) compared to Swept Source (0.113–0.644). The test-retest reliability indices were generally better using AngioVue than Swept Source. Conclusions AngioVue showed better diagnostic capability and test-retest reliability compared to Swept Source. Further studies need to be undertaken to evaluate if there is any significant difference between the various machines in diagnosing and monitoring glaucoma.

Download Full-text

Long-Term Changes of Macular Thickness after Pars Plana Vitrectomy in Optic Disc Pit Maculopathy: A Spectral-Domain Optical Coherence Tomography Study

Seminars in Ophthalmology ◽

10.3109/08820538.2015.1068345 ◽

2015 ◽

Vol 32 (3) ◽

pp. 302-308 ◽

Cited By ~ 8

Author(s):

Irini Chatziralli ◽

George Theodossiadis ◽

Dimitrios Panagiotidis ◽

Ioannis Emfietzoglou ◽

Vlassis Grigoropoulos ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Optic Disc ◽

Pars Plana Vitrectomy ◽

Spectral Domain ◽

Optical Coherence ◽

Optic Disc Pit ◽

Long Term Changes ◽

Pars Plana ◽

Optic Disc Pit Maculopathy

Download Full-text

Optical Coherence Tomography Before and After Vitrectomy with Internal Limiting Membrane Removal in a Child with Optic Disc Pit Maculopathy

Japanese Journal of Ophthalmology ◽

10.1007/s10384-004-0225-1 ◽

2005 ◽

Vol 49 (5) ◽

pp. 411-413 ◽

Cited By ~ 28

Author(s):

Kohei Ishikawa ◽

Hiroko Terasaki ◽

Masako Mori ◽

Kimiko Sugita ◽

Yozo Miyake

Keyword(s):

Optical Coherence Tomography ◽

Optic Disc ◽

Internal Limiting Membrane ◽

Optical Coherence ◽

Optic Disc Pit ◽

Before And After ◽

Optic Disc Pit Maculopathy

Download Full-text

Optical coherence tomography angiography of a bilateral optic disc pit

PAMJ Clinical Medicine ◽

10.11604/pamj-cm.2020.3.142.23970 ◽

2020 ◽

Vol 3 ◽

Author(s):

Ahmed Chebil ◽

Racem Choura

Keyword(s):

Optical Coherence Tomography ◽

Optic Disc ◽

Optical Coherence Tomography Angiography ◽

Optical Coherence ◽

Optic Disc Pit

Download Full-text

Detection of neovascularisation in the vitreoretinal interface slab using widefield swept-source optical coherence tomography angiography in diabetic retinopathy

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2020-317983 ◽

2020 ◽

pp. bjophthalmol-2020-317983

Author(s):

Edward S Lu ◽

Ying Cui ◽

Rongrong Le ◽

Ying Zhu ◽

Jay C Wang ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Diabetic Retinopathy ◽

Optic Disc ◽

Proliferative Diabetic Retinopathy ◽

Optical Coherence Tomography Angiography ◽

Optical Coherence ◽

Vitreoretinal Interface ◽

Cross Sectional ◽

Swept Source ◽

Detection Rates

AimsTo compare the efficacy of diabetic retinal neovascularisation (NV) detection using the widefield swept-source optical coherence tomography angiography (WF SS-OCTA) vitreoretinal interface (VRI) Angio slab and SS-OCT VRI Structure slab.MethodsA prospective, observational study was performed at Massachusetts Eye and Ear from January 2019 to June 2020. Patients with proliferative diabetic retinopathy (PDR), patients with non-proliferative diabetic retinopathy and patients with diabetes but without diabetic retinopathy were included. All patients were imaged with WF SS-OCTA using the 12×12 mm Angio scan protocol centred on the fovea and optic disc. The en-face SS-OCTA VRI Angio slab and SS-OCT VRI Structure slab were evaluated for the presence or absence of NV. SS-OCTA B-scan was used to classify NV according to cross-sectional morphology (forward, tabletop or flat). All statistical analyses were performed using SPSS V.26.0.ResultsOne hundred and forty-two eyes of 89 participants were included in the study. VRI Angio detected NV at higher rates compared with VRI Structure (p<0.05). Combining VRI Angio and Structure improved detection rates compared with VRI Angio alone (p<0.05). Due to segmentation errors of the internal limiting membrane, NV with flat morphological classification had lower rates of detection on VRI Angio compared with NV with forward and tabletop morphology (p<0.05).ConclusionsWF SS-OCTA 12×12 mm VRI Angio and SS-OCT VRI Structure imaging centred on the fovea and optic disc detected NV with high sensitivity and low false positives. The VRI slab may be useful to diagnose and monitor PDR in clinical practice.

Download Full-text

Vitreous findings in optic disc pit maculopathy based on optical coherence tomography

Graefe s Archive for Clinical and Experimental Ophthalmology ◽

10.1007/s00417-007-0534-4 ◽

2007 ◽

Vol 245 (9) ◽

pp. 1311-1318 ◽

Cited By ~ 43

Author(s):

Panagiotis G. Theodossiadis ◽

Vlassis G. Grigoropoulos ◽

John Emfietzoglou ◽

George P. Theodossiadis

Keyword(s):

Optical Coherence Tomography ◽

Optic Disc ◽

Optical Coherence ◽

Optic Disc Pit ◽

Optic Disc Pit Maculopathy

Download Full-text

Multimodal imaging of optic disc melanocytoma

European Journal of Ophthalmology ◽

10.1177/11206721211010616 ◽

2021 ◽

pp. 112067212110106

Author(s):

Cinzia Mazzini ◽

Giulio Vicini ◽

Cristina Nicolosi ◽

Giulia Pieretti ◽

Stanislao Rizzo

Keyword(s):

Optical Coherence Tomography ◽

Optic Disc ◽

Multimodal Imaging ◽

Fundus Autofluorescence ◽

Case Series ◽

Optical Coherence ◽

Retrospective Case ◽

Swept Source ◽

Rule Out

Purpose: To describe the findings of four patients (four eyes) with optic disc melanocytoma (ODM), using multimodal imaging. Methods: Retrospective case series. Results: On ocular ultrasonography ODMs appeared as hyperechogenic lesions with moderate-to-high internal reflectivity. On blue-light fundus autofluorescence, ODMs showed total hypoautofluorescence, while, on infrared reflectance images appeared as bright and well-marginated lesions. MultiColor composite images showed reddish-brown lesions with well-defined margins. Swept-source optical coherence tomography revealed elevated lesions covering the optic disc with an irregular hyperreflective surface, dishomogeneous internal structure with hyperreflective dots, and posterior shadowing. In all cases optical coherence tomography angiography detected intratumoral blood vessels which were not detectable with fluorescein angiography. Conclusion: Multimodal imaging in ODM might be useful both at presentation, increasing the diagnostic accuracy, and at follow-up, providing helpful details, that can help to rule out the possibility of malignant transformation and other ocular complications.

Download Full-text