scholarly journals Fetal Therapy for Congenital Diaphragmatic Hernia: Establishing An Ovine Model

2018 ◽  
Vol 54 ◽  
pp. 27-27
Keyword(s):  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Fetal Therapy ◽  
Ovine Model

scholarly journals OP18.05: Evaluating variability in antenatal sonographic prognostication of congenital diaphragmatic hernia across the North American Fetal Therapy Network

2018 ◽  
Vol 52 ◽  
pp. 120-120
Author(s):  
N. Abbasi ◽  
G. Ryan ◽  
M. Sanz Cortes ◽  
R. Ruano ◽  
A. Johnson
Keyword(s):  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
North American ◽  
Fetal Therapy ◽  
The North

Prenatal assessment of congenital diaphragmatic hernia at north american fetal therapy network centers: A continued plea for standardization

2020 ◽  
Author(s):  
Erin E. Perrone ◽  
Nimrah Abbasi ◽  
Magdalena Sanz Cortes ◽  
Uzma Umar ◽  
Greg Ryan ◽  
...  
Keyword(s):  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
North American ◽  
Fetal Therapy

Impact of Congenital Diaphragmatic Hernia on Lung Development: Parenchymal and Vascular Changes in an Ovine Model

2002 ◽  
Vol 103 (s47) ◽  
pp. 53P-53P
Author(s):  
SM Nelson ◽  
CA Hajivassiliou ◽  
AD Cameron ◽  
G Haddock ◽  
P Dunkley ◽  
...  
Keyword(s):  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Lung Development ◽  
Vascular Changes ◽  
Ovine Model

Neonatal and fetal therapy of congenital diaphragmatic hernia-related pulmonary hypertension

2021 ◽  
pp. fetalneonatal-2021-322617
Author(s):  
Felix R De Bie ◽  
Catherine M Avitabile ◽  
Luc Joyeux ◽  
Holly L Hedrick ◽  
Francesca M Russo ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Future Research ◽  
Fetal Therapy ◽  
Mortality And Morbidity ◽  
Pulmonary Vasodilation ◽  
Experimental Drug ◽  
Therapeutic Mechanisms ◽  
Experimental Treatments

Congenital diaphragmatic hernia (CDH) is a complex malformation characterised by a triad of pulmonary hypoplasia, pulmonary hypertension (PH) and cardiac ventricular dysfunction. Much of the mortality and morbidity in CDH is largely accounted for by PH, especially when persistent beyond the neonatal period and refractory to available treatment. Gentle ventilation, haemodynamic optimisation and pulmonary vasodilation constitute the foundations of neonatal treatment of CDH-related PH (CDH-PH). Moreover, early prenatal diagnosis, the ability to assess severity and the developmental nature of the condition generate the perfect rationale for fetal therapy. Shortcomings of currently available clinical therapies in combination with increased understanding of CDH pathophysiology have spurred experimental drug trials, exploring new therapeutic mechanisms to tackle CDH-PH. We herein discuss clinically available neonatal and fetal therapies specifically targeting CDH-PH and review the most promising experimental treatments and future research avenues.

Expression of surfactant proteins and thyroid transcription factor 1 in an ovine model of congenital diaphragmatic hernia

2002 ◽  
Vol 37 (10) ◽  
pp. 1393-1398 ◽  
Author(s):  
Alexandra Benachi ◽  
Bernadette Chailley-Heu ◽  
Anne-Marie Barlier-Mur ◽  
Yves Dumez ◽  
Jacques Bourbon
Keyword(s):  
Transcription Factor ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Surfactant Proteins ◽  
Ovine Model ◽  
Thyroid Transcription Factor 1 ◽  
Thyroid Transcription Factor ◽  
Transcription Factor 1

Phospholipid Profile of Amniotic Fluid in Ovine Model of Congenital Diaphragmatic Hernia (CDH): The Effect of Fetal Tracheal Occlusion

2015 ◽  
Vol 14 (3) ◽  
pp. 1465-1471 ◽  
Author(s):  
Maria Chiara Mimmi ◽  
Maurizio Ballico ◽  
Francesco Amoroso ◽  
Valeria Calcaterra ◽  
Mario Marotta ◽  
...  
Keyword(s):  
Amniotic Fluid ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Ovine Model ◽  
Tracheal Occlusion ◽  
Phospholipid Profile

scholarly journals BMP4 and LGL1 are Down Regulated in an Ovine Model of Congenital Diaphragmatic Hernia

2014 ◽  
Vol 1 ◽  
Author(s):  
Heather M. A. Emmerton-Coughlin ◽  
K. Kathryn Martin ◽  
Jacky S. S. Chiu ◽  
Lin Zhao ◽  
Leslie A. Scott ◽  
...  
Keyword(s):  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Ovine Model

scholarly journals VP20.03: The TOTAL trial dilemma: a survey among professionals on equipoise regarding fetal therapy for severe congenital diaphragmatic hernia

2020 ◽  
Vol 56 (S1) ◽  
pp. 138-138
Author(s):  
S. Vergote ◽  
D. Pizzolato ◽  
F. Russo ◽  
K. Dierickx ◽  
J. Deprest ◽  
...  
Keyword(s):  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Fetal Therapy ◽  
Total Trial

Impaired endothelial cell nitric oxide signaling in an ovine model of congenital diaphragmatic hernia

2013 ◽  
Vol 217 (3) ◽  
pp. S83
Author(s):  
Shannon N. Acker ◽  
Gregory J. Seedorf ◽  
Jason Gien ◽  
Eva Nozik-Grayck ◽  
David A. Partrick ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Endothelial Cell ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Ovine Model ◽  
Nitric Oxide Signaling
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