scholarly journals Non-surgical periodontal therapy with systemic antibiotics in patients with untreated chronic periodontitis: a systematic review and meta-analysis

2014 ◽  
Vol 50 (3) ◽  
pp. 294-314 ◽  
Author(s):  
J. A. J. Keestra ◽  
I. Grosjean ◽  
W. Coucke ◽  
M. Quirynen ◽  
W. Teughels
2018 ◽  
Vol 68 (4) ◽  
pp. 207-220 ◽  
Author(s):  
Maria Luisa S. Souto ◽  
Emanuel S. Rovai ◽  
Juliana A. Ganhito ◽  
Marinella Holzhausen ◽  
Leandro Chambrone ◽  
...  

2016 ◽  
Vol 20 (5) ◽  
pp. 903-914 ◽  
Author(s):  
Zohaib Akram ◽  
Syarida Hasnur Safii ◽  
Rathna Devi Vaithilingam ◽  
Nor Adinar Baharuddin ◽  
Fawad Javed ◽  
...  

Author(s):  
Sudhir L. Munasur ◽  
Eunice B. Turawa ◽  
Usuf M.E. Chikte ◽  
Alfred Musekiwa

In this systematic review, we assessed the effectiveness of systemic antibiotics as an adjunctive therapy to mechanical debridement in improving inflammatory systemic biomarkers, as compared to mechanical debridement alone, among adults with chronic periodontitis. We searched relevant electronic databases for eligible randomized controlled trials. Two review authors independently screened, extracted data, and assessed risk of bias. We conducted meta-analysis, assessed heterogeneity, and assessed certainty of evidence using GRADEPro software. We included 19 studies (n = 1350 participants), representing 18 randomized controlled trials and found very little or no impact of antibiotics on inflammatory biomarkers. A meta-analysis of eight studies demonstrated a mean reduction of 0.26 mm in the periodontal pockets at three months (mean difference [MD] −0.26, 95%CI: −0.36 to −0.17, n = 372 participants, moderate certainty of evidence) in favor of the antibiotics. However, results from five studies reporting clinical attachment level (mm) yielded little or no difference at three months (MD −0.16, 95% CI: −0.35 to 0.03, n = 217 participants) between antibiotic and placebo groups. There is little or no evidence that adjunctive systemic antibiotics therapy improves inflammatory systemic biomarkers, compared to mechanical debridement alone, among adults with chronic periodontitis.


2011 ◽  
Vol 28 (2) ◽  
pp. 669-682 ◽  
Author(s):  
Fabrizio Sgolastra ◽  
Ambra Petrucci ◽  
Roberto Gatto ◽  
Giuseppe Marzo ◽  
Annalisa Monaco

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