Gut microbiota dysbiosis in patients with hepatitis B virus–induced chronic liver disease covering chronic hepatitis, liver cirrhosis and hepatocellular carcinoma

2019 ◽  
Vol 27 (2) ◽  
pp. 143-155 ◽  
Author(s):  
Yongbin Zeng ◽  
Shanjian Chen ◽  
Ya Fu ◽  
Wennan Wu ◽  
Tianbin Chen ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cirrhosis ◽  
Chronic Hepatitis ◽  
Liver Disease ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Gut Microbiota ◽  
Chronic Liver Disease ◽  
B Virus ◽  
Gut Microbiota Dysbiosis

Pathogenesis of chronic liver disease in patients with chronic hepatitis B virus infection without serum HBeAg

1996 ◽  
Vol 41 (12) ◽  
pp. 2447-2452 ◽  
Author(s):  
Alessandra Mangia ◽  
Young-Hwa Chung ◽  
Jay H. Hoofnagle ◽  
Larry Birkenmeyer ◽  
Isa Mushahwar ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Liver Disease ◽  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Chronic Liver Disease ◽  
Chronic Hepatitis B ◽  
Hepatitis B Virus Infection ◽  
Chronic Hepatitis B Virus ◽  
B Virus

Integration of Hepatitis B Virus DNA into the Genome of Liver Cells in Chronic Liver Disease and Hepatocellular Carcinoma

1981 ◽  
Vol 305 (18) ◽  
pp. 1067-1073 ◽  
Author(s):  
David A. Shafritz ◽  
Daniel Shouval ◽  
Howard I. Sherman ◽  
Stefanos J. Hadziyannis ◽  
Michael C. Kew
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Disease ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Chronic Liver Disease ◽  
Liver Cells ◽  
Chronic Liver ◽  
Hepatitis B Virus Dna ◽  
B Virus

scholarly journals Anti-Hepatitis B Virus X Protein in Sera Is One of the Markers of Development of Liver Cirrhosis and Liver Cancer Mediated by HBV

2009 ◽  
Vol 2009 ◽  
pp. 1-6 ◽  
Author(s):  
Hang Zhang ◽  
Lian-Ying Wu ◽  
Shuai Zhang ◽  
Li-Yan Qiu ◽  
Nan Li ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cirrhosis ◽  
Chronic Hepatitis ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Enzyme Linked Immunosorbent Assay ◽  
X Protein ◽  
Hbv Replication ◽  
B Virus ◽  
Circulating Antibody

Hepatitis B virus X protein (HBx) plays a crucial role in the development of hepatocellular carcinoma (HCC). However, the significance of circulating antibody to hepatitis B virus X antigen (anti-HBx) in sera remains unclear. In the present study, we examined the titers of anti-HBx (IgG) in the sera from 173 patients with chronic hepatitis B (CHB), 106 liver cirrhosis (LC), and 61 HCC by enzyme-linked immunosorbent assay (ELISA), respectively. Our data showed that the positive rates of anti-HBx were higher in sera of LC (40.6%) and HCC (34.4%) than those of CHB (10.4%),P<.05. In all 40 patients with anti-HBx+ out of 340 patients, 39 (97.5%) were HBsAg/HBeAg/anti-HBc+ and 1 (2.5%) was anti-HBs+ (P<.01), suggesting that anti-HBx in sera is a marker of HBV replication rather than a protective antibody. Thus, our findings reveal that circulating anti-HBx in sera is one of the markers of development of LC and HCC mediated by HBV.

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